Bioinformatics and Pathways Core

生物信息学和通路核心

• 批准号: 10474291
• 负责人: Jonathan Daniel Wren
• 金额: $ 37.65万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474291
• 关键词: Animal Model; Applications Grants; Award; Bioinformatics; Biological; Centers of Research Excellence; ChIP-seq; Chemicals; Computer software; Core Facility; Data Analyses; Data Sources; Databases; Development; Developmental Biology; Doctor of Philosophy; Ensure; Funding; Gene Expression; Genes; Genetic Transcription; Genomic Segment; Genomics; Grant; High-Throughput Nucleotide Sequencing; Human Resources; Informatics; Institution; Literature; Meta-Analysis; Methods; Oklahoma; Participant; Pathway Analysis; Pathway interactions; Peer Review; Phase; Phenotype; Pilot Projects; Preparation; Property; Publications; Published Comment; Publishing; Quality Control; Research; Research Design; Research Personnel; Research Project Grants; Resource Informatics; Sample Size; Scientist; Transcript; Troglodytinae; Untranslated RNA; Work; base; bioinformatics infrastructure; design; differential expression; disease phenotype; experience; experimental analysis; experimental study; interest; novel; power analysis; programs; public database; skills; statistics; tool; transcriptome sequencing

Abstract This Developmental Biology Phase II COBRE Bioinformatics and Pathways Core (BPC) will provide dedicated bioinformatics and statistical support for all Junior Investigators and Pilot Project Investigators. In particular, we will help with processing, quality control, analysis and interpretation of high-throughput sequencing experiments such as RNA-seq, ChIP-seq, and genomic analyses. Additionally, the BPC has a dedicated Ph.D.-level statistician who will provide continuous statistical support, both in the design and interpretation of experiments. We have extensive experience in the effective use of state-of-the-art bioinformatics methods and software, as well as a track record in developing novel methods to help interpret experimental findings. We will also work proactively with the Junior Investigators to identify how informatics approaches can help their research, and develop new informatics resources accordingly. The BPC will help and support COBRE investigators as they submit their grants for independent research funding, both in preparation of the relevant sections on data analysis and statistics, as well as in post-award analyses. The BPC is led by Dr. Jonathan Wren, a bioinformatician with 128 peer-reviewed publications and 14 years of experience, and two Ph.D.-level scientists on staff. Our top priorities are to continue to build our bioinformatics infrastructure to help Junior Investigators and Pilot Project Investigators with data analysis, data interpretation and identification of promising new experimental leads.

摘要 这个发育生物学第二阶段COBRE生物信息学和途径核心（BPC）将提供 为所有初级研究者和试点项目研究者提供专门的生物信息学和统计支持。在 特别是，我们将帮助处理，质量控制，分析和解释高通量 测序实验，如RNA-seq，ChIP-seq和基因组分析。此外，BPC还有一个 专注的博士学位-一级统计员，将在设计和 实验的解释。我们在有效使用最先进的 生物信息学方法和软件，以及在开发新方法，以帮助解释 实验发现。我们还将积极与初级研究人员合作，以确定信息学如何 方法可以帮助他们的研究，并相应地开发新的信息学资源。BPC将帮助 并支持COBRE研究人员提交独立研究资金的赠款， 编写关于数据分析和统计以及授标后分析的相关章节。的 BPC由Jonathan Wren博士领导，他是一位生物信息学家，拥有128篇同行评议的出版物和14年的 经验和两个博士学位-工作人员中有一级科学家。我们的首要任务是继续建立我们的生物信息学 帮助初级研究者和试点项目研究者进行数据分析、数据解释的基础设施 和鉴定有希望的新实验线索