USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub

USC FaceBase III 颅面发育和畸形数据管理和集成中心

基本信息

批准号：
10227702
负责人：
Yang Chai
金额：
$ 254.85万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10227702
关键词：
Address Anatomy Animal Model Architecture Area Biology Biomedical Research Cells Collection Communication Communities Computers Craniofacial Abnormalities Data Data Set Development Dysmorphology Education and Outreach Educational Materials Ensure FAIR principles Face FaceBase Fostering Funding Future Genetic Goals Health Human Image Infrastructure Knowledge Lead Link Modeling Molecular National Institute of Dental and Craniofacial Research Outcome Phase Process Reproducibility Research Research Design Research Personnel Research Support Resources Retrieval Scientist Study models Training Training Activity Translating Visualization base community engagement craniofacial craniofacial development data curation data hub data integration data management data repository data resource data sharing data submission design experience experimental study heterogenous data high standard human data human model improved innovation large datasets next generation operation outreach posters quality assurance tool training opportunity usability user-friendly

项目摘要

PROJECT SUMMARY The major goal of the FaceBase Consortium is to advance research by creating comprehensive datasets of craniofacial development and dysmorphologies, and to disseminate these datasets to the wider craniofacial research community. The FaceBase 3 Data Management and Integration Hub builds on the existing and successful scientific and technical team that has lead the development, deployment, operation and community engagement of the FaceBase 2 data hub. Looking forward to the future impact of the FaceBase Consortium, we face major challenges that include: (1) how to annotate large datasets to empower the biomedical research community; (2) how to improve data integration and facilitate data search and retrieval from the hub; (3) how to use the data from FaceBase to design studies and otherwise inform our future research; and (4) how to translate our knowledge from animal model studies to improve human craniofacial health. Importantly, the projects we propose here are designed to address these issues as we develop anatomy-based comprehensive data search and display, incorporate additional datasets from the community, and promote the usage of FaceBase data. In pursuit of these goals, we propose the following three Specific Aims: Specific Aim 1: Create a FAIR data repository and resource hub for the craniofacial research community. Specific Aim 2: Promote and enable data contributions to FaceBase by NIDCR-supported researchers. Specific Aim 3: Foster a community of active FaceBase users through outreach activities and dissemination of new features and available datasets. We will create educational materials and provide training opportunities for the next generation of craniofacial researchers. Ultimately, our proposed projects will not only contribute to our comprehensive understanding of the molecular regulatory mechanisms of craniofacial development but will also demonstrate how others can use the datasets from the FaceBase Hub to develop innovative approaches to improve human health.

项目摘要 Facebase联盟的主要目标是通过创建全面的数据集来推进研究颅面发展和畸形学，并将这些数据集传播到更广泛的颅面研究社区。 Facebase 3数据管理和集成集线器建立在现有和成功领导发展，部署，运营和社区的成功科学技术团队 Facebase 2数据中心的参与度。期待面对面财团的未来影响，我们面临主要挑战，包括：（1）如何注释大型数据集以增强生物医学研究社区; （2）如何改善数据集成并促进来自集线器的数据搜索和检索；（3）如何使用Facebase的数据设计研究，以其他方式为我们的未来研究提供信息；（4）如何翻译我们从动物模型研究中的知识来改善人类颅面健康。重要的是，我们的项目当我们开发基于解剖学的综合数据搜索时，这里的建议旨在解决这些问题并显示，结合社区的其他数据集，并促进面库数据的使用。在追求这些目标，我们提出以下三个特定目标：特定目标1：创建一个公平的数据颅面研究社区的存储库和资源枢纽。特定目标2：促进和启用数据由NIDCR支持的研究人员对面孔的贡献。特定目标3：培养一个活跃的社区通过外展活动和传播新功能和可用数据集的面孔用户。我们将创建教育材料并为下一代颅面提供培训机会研究人员。最终，我们拟议的项目不仅有助于我们对颅面发育的分子调节机制，但也将证明他人如何使用 Facebase Hub的数据集开发了改善人类健康的创新方法。