Supplement Year 2: USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub

项目摘要 FaceBase联盟的主要目标是通过创建 颅面发育和畸形的综合数据集， 将这些数据集传播到更广泛的颅面研究社区。的 FaceBase 3数据管理和集成中心建立在现有的 成功的科学和技术团队，领导了开发，部署， FaceBase 2数据中心的运营和社区参与。看 展望FaceBase联盟未来的影响，我们面临着重大挑战 包括：（1）如何标注大型数据集以支持生物医学研究 （2）如何改善数据整合和促进数据搜索， 从中心检索;（3）如何使用FaceBase的数据来设计研究， 否则通知我们未来的研究;（4）如何将我们的知识从 改善人类颅面健康的动物模型研究。重要的是，项目 我们在这里提出的设计是为了解决这些问题，因为我们发展解剖学- 基于全面的数据搜索和显示， 社区，并促进FaceBase数据的使用。为了实现这些目标， 我们提出以下三个具体目标：具体目标1：创建FAIR数据 颅面研究社区的知识库和资源中心。具体目标 2：促进和实现由NIDCR支持的FaceBase数据贡献 研究人员具体目标3：通过以下方式培养活跃的FaceBase用户社区 外联活动和传播新的特点和现有数据集。我们 将创建教育材料，并提供培训机会，为下一个 颅面研究者的一代。最终，我们提出的项目将不会 有助于我们全面了解 颅面发育的机制，但也将展示如何其他人可以 使用FaceBase Hub的数据集开发创新方法， 改善人类健康。

PROJECT SUMMARY The major goal of the FaceBase Consortium is to advance research by creating comprehensive datasets of craniofacial development and dysmorphologies, and to disseminate these datasets to the wider craniofacial research community. The FaceBase 3 Data Management and Integration Hub builds on the existing and successful scientific and technical team that has lead the development, deployment, operation and community engagement of the FaceBase 2 data hub. Looking forward to the future impact of the FaceBase Consortium, we face major challenges that include: (1) how to annotate large datasets to empower the biomedical research community; (2) how to improve data integration and facilitate data search and retrieval from the hub; (3) how to use the data from FaceBase to design studies and otherwise inform our future research; and (4) how to translate our knowledge from animal model studies to improve human craniofacial health. Importantly, the projects we propose here are designed to address these issues as we develop anatomy- based comprehensive data search and display, incorporate additional datasets from the community, and promote the usage of FaceBase data. In pursuit of these goals, we propose the following three Specific Aims: Specific Aim 1: Create a FAIR data repository and resource hub for the craniofacial research community. Specific Aim 2: Promote and enable data contributions to FaceBase by NIDCR-supported researchers. Specific Aim 3: Foster a community of active FaceBase users through outreach activities and dissemination of new features and available datasets. We will create educational materials and provide training opportunities for the next generation of craniofacial researchers. Ultimately, our proposed projects will not only contribute to our comprehensive understanding of the molecular regulatory mechanisms of craniofacial development but will also demonstrate how others can use the datasets from the FaceBase Hub to develop innovative approaches to improve human health.