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Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detection

Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detection
研究早期青光眼的纳米级神经元损伤以进行临床光学检测
批准号:
10228558
负责人:
Xiaorong Liu
金额:
$50.75万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-06-01 至 2024-05-31

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中文摘要
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英文摘要
Project Summary Our long-term goal is to develop new functional extensions of optical coherence tomography (vis-OCT) for clinical diagnosis and management of glaucoma. Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) and optic nerve defects and atrophy, afflicting more than 60 million people worldwide. It is often develops slowly with symptoms and damage that are not noticed at early stage. Caring for those with glaucomatous vision disability poses a huge burden on the US health care system. Early detection and screening techniques at asymptomatic stage is thus of critical importance for better management of the disease and will have paramount clinical and economic impacts. In this proposal, the power of the ultrahigh axial resolution (~1 µm) will be harnessed and the increased optical contrast sensitivity offered by visible-light OCT (vis-OCT) to investigate the mechanism of optically detectable alterations underlying early retinal ganglion cell (RGC) damage in mouse models of experimental glaucoma. The proposed study will serve as the foundation for objective and sensitive early clinical diagnosis of glaucoma using OCT. First, the investigators will establish vis-OCT methodology to detect RGC and axon damage using an acute mouse model of nerve crush injury. Then, the investigators will determine physiological origin of vis-OCT detected RGC ultrastructural alterations in a chronic model of experimental glaucoma. Finally, the investigators will determine that vis-OCT detected RGC ultrastructural alterations proceeds the structural and functional metrics used for clinical glaucoma diagnoses in a chronic model of experimental glaucoma.
期刊论文(18)
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会议论文
DOI: 10.4103/1673-5374.343906
发表时间: 2023-01
期刊: NEURAL REGENERATION RESEARCH
影响因子: 6.1
作者: [Liu, Xiaorong, Zhang, Hao F.]
通讯作者: Zhang, Hao F.
DOI: 10.1038/s41377-020-0333-9
发表时间: 2020-05-25
期刊: LIGHT-SCIENCE & APPLICATIONS
影响因子: 19.4
作者: [Song, Ki-Hee, Zhang, Yang, Zhang, Hao F.]
通讯作者: Zhang, Hao F.
DOI: 10.1093/bioinformatics/btaa635
发表时间: 2020-10-01
期刊: BIOINFORMATICS
影响因子: 5.8
作者: [Davis, Janel L., Soetikno, Brian, Zhang, Hao F.]
通讯作者: Zhang, Hao F.
DOI: 10.1021/jacs.8b09099
发表时间: 2018-10-10
期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子: 15
作者: [Zhang, Yang, Song, Ki-Hee, Tang, Sicheng, Ravelo, Laura, Cusido, Janet, Sun, Cheng, Zhang, Hao F., Raymo, Francisco M.]
通讯作者: Raymo, Francisco M.
12
    Modulating aqueous humor outflow with engineered nanoparticles for glaucoma
    Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    • 批准号:
      8136019
    • 项目类别:
    • 资助金额:
      $32.62万
    • 财政年份:
      2008
    • 负责人:
      Xiaorong Liu
    • 依托单位:
    Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    • 批准号:
      7684132
    • 项目类别:
    • 资助金额:
      $33.98万
    • 财政年份:
      2008
    • 负责人:
      Xiaorong Liu
    • 依托单位:
    Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    • 批准号:
      7944376
    • 项目类别:
    • 资助金额:
      $10.0万
    • 财政年份:
      2008
    • 负责人:
      Xiaorong Liu
    • 依托单位:
    海外基金