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Cesium Irradiator 137 Shared Resource

铯辐照器 137 共享资源

基本信息

批准号：
10228165
负责人：
RAVINDER NATH
金额：
$ 4.29万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10228165
关键词：
Animal Experiments Animals Antitumor Response Apoptosis Basic Science Biological Cancer Center Support Grant Capital Cell Culture Techniques Cells Cesium Chemicals Collimator Consultations Controlled Environment DNA Devices Doctor of Philosophy Dose-Rate Epigenetic Process Funding Genetic Genomics Human Immune response Immunosuppression Individual Infection Ionizing radiation Laboratories Lesion Malignant Neoplasms Molecular Mus Mutation Pathway interactions Physicians Radiation Radiation Physics Radiation induced damage Research Research Personnel Resource Sharing Resources Sampling Scientist Services Spleen Technology Training Transgenic Animals Universities Virus Yale Cancer Center anticancer research biological effect of radiation cost effective design experimental study gamma irradiation improved irradiation member neoplastic cell programs radiation effect repaired research study tool tumor immunology

项目摘要

CESIUM-137 IRRADIATOR SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Cesium-137 Irradiator Shared Resource was established in 1991 to provide accurate, convenient and reliable access to ionizing radiation to Yale University investigators for irradiations of molecular compounds, cell cultures, animal and human tumor cells, and whole animal experiments. It continues to serve as a valuable research tool for researchers who are studying the effects of radiation on biological samples, animals, and cells in culture or are using radiation as part of their experiments to create mutations for studying the biologic effect of radiation, of mutations themselves, or for immunosuppression. Given the concentration of investigators at Yale studying DNA, it is an essential resource. The Cesium-137 Irradiator offers a wide range of dose rates, collimation and a controlled environment for irradiation samples. Approximately 32 YCC investigators per year have used this device in the last 5 years, to provide precise irradiation to any sample, whether biological or chemical. During our most recent funding period (FY17), 31 people used the Cesium-137 Irradiator. Twenty of these users (65%) were YCC members who accounted for 83% of total resource use. The majority of this use came from Genomics, Genetics and Epigenetics (GGE), Cancer Immunology (CI), and Virus and Other Infection-associated Cancers (VOIC). The Cesium-137 Irradiator Shared Resource serves as a central resource for irradiation and brings a high level of expertise in radiation research to the members of YCC. The results from the many basic research studies that involved the Cesium-137 Irradiator have enabled YCC physicians to improve their ability to detect and treat cancer efficaciously. Ravinder Nath, PhD, (RR), has served as the Director of the Cesium-137 Irradiator Shared Resource since its inception. The Specific Aims of the Cesium-137 Irradiator Shared Resource are to provide: (1) Access to a state-of-the- art Cesium-137 Irradiator, cost-effective irradiator services, and highly skilled technical assistance to all YCC members; (2) Consultation on the design of experiments involving the Cesium-137 Irradiator; (3) Training for the staff of YCC members on the use of the Cesium-137 Irradiator; and (4) Irradiator availability 24 hrs/day, 365 days/year for any cancer investigator whose research requires gamma irradiation.

铯-137辐照体共享资源