Cesium Irradiator 137 Shared Resource

铯-137辐照器共享资源 项目总结/摘要 铯-137辐照器共享资源建立于1991年，旨在提供准确、方便、 耶鲁大学的研究人员可靠地获得电离辐射，以辐照分子化合物， 细胞培养物、动物和人肿瘤细胞以及整个动物实验。它仍然是一个有价值的 为研究辐射对生物样本、动物和细胞影响的研究人员提供的研究工具 或者使用辐射作为实验的一部分，以创造突变来研究生物效应。 辐射、突变本身或免疫抑制。鉴于调查人员集中在 耶鲁大学研究DNA，这是一个重要的资源。铯-137辐照器提供广泛的剂量率， 准直和辐照样品的受控环境。 在过去5年中，每年约有32名YCC研究者使用该器械，以提供精确的 辐照任何样品，无论是生物或化学。在我们最近的融资期间（FY 17），31 人们使用铯-137辐射器这些用户中有20人（65%）是YCC成员， 占总资源的83%。大部分使用来自基因组学，遗传学和表观遗传学（GGE）， 癌症免疫学（CI）和病毒和其他预防相关癌症（VOIC）。 铯-137辐照器共享资源作为辐照的中心资源， 辐射研究的专业知识。许多基础研究的结果 涉及铯-137辐照器的研究使YCC医生能够提高他们的检测能力， 有效地治疗癌症。Ravinder Nath博士（RR）曾担任铯-137辐照器的主任 资源共享自成立以来 铯-137辐照器共享资源的具体目标是：（1）获得一个国家的- art铯-137辐照器，具有成本效益的辐照器服务，并为所有YCC提供高技能的技术援助 （2）关于铯-137辐照器实验设计的协商;（3）关于下列问题的培训： YCC成员的工作人员使用铯-137辐照器;和（4）辐照器24小时可用， 365天/年，适用于研究需要伽马辐照的任何癌症研究者。

CESIUM-137 IRRADIATOR SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Cesium-137 Irradiator Shared Resource was established in 1991 to provide accurate, convenient and reliable access to ionizing radiation to Yale University investigators for irradiations of molecular compounds, cell cultures, animal and human tumor cells, and whole animal experiments. It continues to serve as a valuable research tool for researchers who are studying the effects of radiation on biological samples, animals, and cells in culture or are using radiation as part of their experiments to create mutations for studying the biologic effect of radiation, of mutations themselves, or for immunosuppression. Given the concentration of investigators at Yale studying DNA, it is an essential resource. The Cesium-137 Irradiator offers a wide range of dose rates, collimation and a controlled environment for irradiation samples. Approximately 32 YCC investigators per year have used this device in the last 5 years, to provide precise irradiation to any sample, whether biological or chemical. During our most recent funding period (FY17), 31 people used the Cesium-137 Irradiator. Twenty of these users (65%) were YCC members who accounted for 83% of total resource use. The majority of this use came from Genomics, Genetics and Epigenetics (GGE), Cancer Immunology (CI), and Virus and Other Infection-associated Cancers (VOIC). The Cesium-137 Irradiator Shared Resource serves as a central resource for irradiation and brings a high level of expertise in radiation research to the members of YCC. The results from the many basic research studies that involved the Cesium-137 Irradiator have enabled YCC physicians to improve their ability to detect and treat cancer efficaciously. Ravinder Nath, PhD, (RR), has served as the Director of the Cesium-137 Irradiator Shared Resource since its inception. The Specific Aims of the Cesium-137 Irradiator Shared Resource are to provide: (1) Access to a state-of-the- art Cesium-137 Irradiator, cost-effective irradiator services, and highly skilled technical assistance to all YCC members; (2) Consultation on the design of experiments involving the Cesium-137 Irradiator; (3) Training for the staff of YCC members on the use of the Cesium-137 Irradiator; and (4) Irradiator availability 24 hrs/day, 365 days/year for any cancer investigator whose research requires gamma irradiation.