Toward novel translucent and strong nanostructured dental zirconia

开发新型半透明且坚固的纳米结构牙科氧化锆

• 批准号: 10273470
• 负责人: Yu Zhang
• 金额: $ 25.61万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10273470
• 关键词: Address; Behavior; Biological Models; Ceramics; Chemical Warfare; Clinical; Conflict (Psychology); Data; Dental; Dental Porcelain; Dental Technicians; Dentistry; Dependence; Development; Elements; Engineering; Esthetics; Evaluation; Exhibits; Failure; Fatigue; Fracture; Goals; Grain; Healthcare; High temperature of physical object; Industry; Knowledge; Laboratories; Laws; Light; Macor; Mechanics; Metals; Methodology; Methods; Military Personnel; Modernization; Morbidity - disease rate; Motion; Nanostructures; Nature; Oral cavity; Property; Prosthesis; Public Health; Quality of life; Research; Resistance; Stress Fractures; Structure; Technology; Testing; Time; Tooth structure; Ultrafine; base; clinically relevant; cost; improved; innovation; knowledge base; mechanical properties; minimally invasive; nano; nanopowder; nanoscale; next generation; novel; premature; preservation; restorative ceramics; restorative dentistry; restorative material; simulation; success; yttria; zirconium oxide

Project Summary/Abstract The attainment of both translucency and strength is a vital requirement for ceramic restorative materials. Unfortunately, these properties are often mutually exclusive. Porcelain-based and glass-ceramic materials have higher translucency but lower strength, and are thus susceptible to premature failure. Zirconia-based ceramics are stronger and tougher but have poor translucency. There is therefore an urgent need to develop translucent and strong ceramics for the next generation of better-performing restorative materials. Accordingly, the long-term goal of this project is to develop esthetic, strong, and abrasion-resistant nanocrystalline yttria- stabilized tetragonal zirconia polycrystals (Y-TZP) for dental and biomedical applications. The overall objectives in this application are: (1) optimize the translucency and strength of nanocrystalline Y-TZP via compositional and microstructural tailoring; and (2) elucidate microstructure-mechanical properties of Y-TZP at the nano and microscale levels. To our knowledge, this proposal is the first to systematically address these questions. The central hypothesis is that nanocrystalline Y-TZP exhibits improved translucency, strength and reduced abrasiveness relative to its microcrystalline counterparts. This hypothesis is formulated on the basis of preliminary results produced in the applicants’ laboratories. To test this hypothesis, we will pursue 3 specific aims: (1) Optimize nanostructured Y-TZP for translucency and strength; (2) Elucidate the dependence of translucency, strength degradation and toughness on Y-TZP microstructure; and (3) Determine resistance to fatigue and wear of nanostructured Y-TZP using a mouth-motion simulator. The approach is innovative because it departs from the status quo by developing a new form of nanocrystalline Y-TZP with improved translucency and fracture resistance and reduced abrasiveness using novel processing methodologies. The proposed research is significant because it extends clinical indications for zirconia to the esthetic zone and promises minimally invasive treatments. Such an approach will prolong prosthetic lifetimes and preserve tooth structure, thus reducing money and time spent correcting premature failures. As an adjunct benefit, the development of nanocrystalline Y-TZP will provide a model system for establishing a broader correlation between mechanical properties and grain size, thus extending classical fracture mechanics laws into the nanoscale domain.

项目摘要/摘要 透明度和强度的达到是陶瓷修复材料的重要要求。 不幸的是，这些特性通常是相互排斥的。基于瓷器和玻璃陶瓷材料 具有较高的透明度但强度较低，因此容易出现过早失败。基于氧化锆 陶瓷既强壮，又强大，但透明度较差。因此，迫切需要发展 半透明且强大的陶瓷，用于下一代表现更好的修复材料。根据 该项目的长期目标是开发审美，耐磨和耐磨的纳米晶体Yttria- 用于牙科和生物医学应用的稳定四方锆多晶体（Y-TZP）。总体 此应用程序中的目标是：（1）优化纳米晶体Y-TZP的透明度和强度 组成和微观结构剪裁； （2）阐明y-tzp的微观力学特性 纳米和微观水平。据我们所知，该提议是第一个系统地解决这些建议的 问题。中心假设是纳米晶Y-TZP表现出改善的透明度，强度和 相对于其微晶对应物降低了磨蚀性。该假设是根据 申请人实验室产生的初步结果。为了检验这一假设，我们将追求3个特定的 目的：（1）优化纳米结构的Y-TZP，以提高透明度和力量； （2）阐明 y-tzp微观结构上的透明度，强度降解和韧性； （3）确定对 使用口腔动作模拟器的纳米结构Y-TZP的疲劳和磨损。这种方法是创新的 因为它通过开发一种新形式的纳米晶体y-tzp来偏离现状 透明度和断裂耐药性，并使用新型加工方法降低了磨料。这 拟议的研究很重要，因为它将氧化锆的临床指示扩展到了审美区和 承诺最少的侵入性治疗方法。这种方法将延长假肢的寿命并保存 结构，从而减少了纠正过早失败的金钱和时间。作为辅助收益， 纳米晶体Y-TZP的开发将提供一个模型系统，以建立更广泛的相关性 在机械性能和晶粒尺寸之间，从而将经典的断裂力学定律扩展到 纳米级域。