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DCEG- Genotyping for epidemiology studies

DCEG-流行病学研究的基因分型

基本信息

批准号：
10273213
负责人：
LEONARD FREEDMAN
金额：
$ 533.19万
依托单位：
LEIDOS BIOMEDICAL RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-31 至 2021-08-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10273213
关键词：
Affect American Cancer Society Area Basic Science Beta Carotene Biological Assay Cancer Burden Caring Cervical Cancer Screening Colon Communities Custom DNA Data Data Analyses Data Storage and Retrieval Development Disease Disease Outcome Division of Cancer Epidemiology and Genetics Employment Environmental Risk Factor Epidemiologist Experimental Designs Family Generations Genes Genetic Genetic Markers Genetic Variation Genome Scan Genomics Genotype Heritability Human Human Genetics Human Genome Human Microbiome Human Papillomavirus Image Immunohistochemistry Individual Informatics Information Management Intramural Research Program Laboratories Laboratory Research Lung Malignant Neoplasms Meta-Analysis Molecular Epidemiology Mutation Normal tissue morphology Nucleic Acids Outcome Ovarian Phenotype Population Population Group Predisposition Prostate Proteomics Publications Publishing Research Research Personnel Research Support Resources Sampling Scanning Scientific Advances and Accomplishments Scientist Specimen Statistical Methods Support Groups Surveys Techniques Technology Technology Transfer Tissues Work alpha Tocopherol anticancer research bioinformatics pipeline cancer genomics cancer prevention case control clinically relevant cohort cost cost effective data access data resource database of Genotypes and Phenotypes design digital digital pathology epidemiology study exome exome sequencing follow-up genetic epidemiology genetic variant genome sequencing genome wide association study genome-wide human genome sequencing human genomics interest large datasets microbiome sequencing molecular pathology novel rare variant screening technology research and development tissue processing tool tumor

项目摘要

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG’s intramural research program, the CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. New work has begun in somatic research with the use of tumor/normal tissue nucleic acids for cross-platform comparisons in subjects of interest. A support group for molecular and digital pathology research within CGR has been added to support these efforts. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, tissue research support, development and implementation of bioinformatic pipelines, and downstream research and analytical support. These factors make CGR a unique collaborative center for NCI-driven scientific endeavors.

癌症基因组研究实验室(CGR)的成立是为了研究基因变异对癌症易感性和结果的贡献。CGR与DCEG内部研究计划中的流行病学家、生物统计学家和基础研究科学家合作，提供了进行全基因组发现研究和有针对性的地区性方法来确定各种形式癌症的可遗传决定因素的能力。在体细胞研究方面已经开始了新的工作，使用肿瘤/正常组织核酸在感兴趣的对象中进行跨平台比较。在CGR内部增加了一个分子和数字病理学研究支持小组，以支持这些努力。CGR在癌症研究从规划到发表的所有阶段为DCEG提供支持，包括实验设计和项目管理、样本处理、基因分型和测序分析设计和执行、组织研究支持、生物信息管道的开发和实施，以及下游研究和分析支持。这些因素使CGR成为NCI驱动的科学努力的独特合作中心。