Host factors contributing to susceptibility to COVID-19 disease

这些研究是NIAID、NIDCR、NCI和NIAMS校内研究项目的多名主要研究人员共同努力的一部分，并与美国基因组中心/健康科学统一服务大学的研究人员达成了一项研究合作协议。我们组织了一个国际合作研究在意大利中心登记的患者，后来扩大到包括东亚和美洲的中心。编写了一份涉及发送样本的新COVID协议，以促进其他缺乏自己的COVID协议的中心的研究，目前正在接受IRB审查。我们已与COVID-Human Genetic Effort合作，目前正在审查这一合作的两份修订手稿，其中涉及先天免疫途径的紊乱与恶化的结果有关。

These studies have been organized as part of a broader effort among multiple principal investigators in the Intramural Research Programs of NIAID, NIDCR, NCI, and NIAMS, as well as a research collaborative agreement with investigators at the American Genome Center/Uniformed Services University of the Health Sciences. We have assembled an international collaboration to study patients enrolled at centers in Italy, which was later expanded to include centers in East Asia and the Americas. A new COVID protocol involving send-in samples was written to facilitate studies at other centers lacking their own COVID protocols, and it is currently undergoing IRB review. We have partnered with the COVID-Human Genetic Effort, and two revised manuscripts from this collaboration, which implicate derangements in an innate immune pathway in worsened outcome, are currently under review.