课题基金 / 基金详情

CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

人源化免疫系统小鼠模型 (IMM-HIS) 的表征和改进

批准号：

10282227

负责人：

JULIE LANG

金额：

$204.14万

依托单位：

UNIVERSITY OF COLORADO DENVER

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

已结题

起止时间：

2020-09-30 至 2023-09-29

来源：

https://reporter.nih.gov/project-details/10282227

关键词：

Allografting Architecture Cells Chimerism Communities Contracts Development Enzyme-Linked Immunosorbent Assay Flow Cytometry Hematopoietic stem cells Human Immune Immune system Immunization Implant Intestines Lead Liver Lung Lymphoid Cell Lymphoid Tissue Measurement Modeling Mus Neonatal Organ Population Production Testing Thymic Tissue Thymus Gland Time Training Transplantation Umbilical Cord Blood Vaccination aged allograft rejection cytokine improved member mouse model tumor growth

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This contract proposes to develop, optimize, and test the production of HIS mice using hematopoietic stem cells from cord blood, including the co-transplantation of neonatal thymic tissue. Comprehensive characterizations of the adaptive and innate human immune systems will include testing its ability to respond to a standard human vaccination and an allograft. The chosen models for optimization and improvement center on increasing populations of innate lymphoid cells which facilitate lymphoid tissue development, that in turn would lead to more robust and complete development of the human immune system.

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