CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)
人源化免疫系统小鼠模型 (IMM-HIS) 的表征和改进
基本信息
- 批准号:10282227
- 负责人:
- 金额:$ 204.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2023-09-29
- 项目状态:已结题
- 来源:
- 关键词:AllograftingArchitectureCellsChimerismCommunitiesContractsDevelopmentEnzyme-Linked Immunosorbent AssayFlow CytometryHematopoietic stem cellsHumanImmuneImmune systemImmunizationImplantIntestinesLeadLiverLungLymphoid CellLymphoid TissueMeasurementModelingMusNeonatalOrganPopulationProductionTestingThymic TissueThymus GlandTimeTrainingTransplantationUmbilical Cord BloodVaccinationagedallograft rejectioncytokineimprovedmembermouse modeltumor growth
项目摘要
This contract proposes to develop, optimize, and test the production of HIS mice using hematopoietic stem cells from cord blood, including the co-transplantation of neonatal thymic tissue. Comprehensive characterizations of the adaptive and innate human immune systems will include testing its ability to respond to a standard human vaccination and an allograft. The chosen models for optimization and improvement center on increasing populations of innate lymphoid cells which facilitate lymphoid tissue development, that in turn would lead to more robust and complete development of the human immune system.
该合同旨在开发,优化和测试使用脐带血造血干细胞生产HIS小鼠,包括新生儿胸腺组织的共同移植。 适应性和先天性人类免疫系统的全面表征将包括测试其对标准人类疫苗接种和同种异体移植物的反应能力。所选择的优化和改进模型集中在促进淋巴组织发育的先天淋巴细胞群体的增加上,这反过来将导致人类免疫系统的更稳健和完整的发育。
项目成果
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