THE GENETICS AND MULTI-OMICS SPECIMENS CORE (GMSC)

遗传学和多组学样本核心 (GMSC)

• 批准号: 10283067
• 负责人: Carlos Cruchaga
• 金额: $ 72.92万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283067
• 关键词: Adult; Aged, 80 and over; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Basic Science; Behavior; Bilirubin; Biocompatible Materials; Bioinformatics; Biological; Biological Markers; Biological databases; Biology; Blood; Blood specimen; Brain; Cholesterol; Clinical Chemistry; Clinical Sciences; Clinical assessments; Cognition; Cognitive; Collection; Complex; Creatinine; DNA; DNA Library; DNA Methylation; Data; Data Analyses; Data Collection; Databases; Dementia; Deposition; Developed Countries; Disease; Elderly; Ensure; Face; Genes; Genetic; Genetic study; Genomics; Genotype; Glial Fibrillary Acidic Protein; Goals; Hormones; Human; Image; Impaired cognition; Individual; Inflammation; Inflammatory; Investigation; Life Style; Light; Liver; Longitudinal Studies; Measurement; Measures; Menopause; Metabolic; Molecular Disease; Multiomic Data; Nerve Degeneration; Neurodegenerative Disorders; Participant; Phenotype; Plasma; Population; Procedures; Process; Proteins; Proteomics; Protocols documentation; Psychometrics; Quality Control; RNA; Renal function; Research Personnel; Sampling; Site; Specimen; Standardization; Testing; Time; Tube; Universities; Visit; Washington; aging brain; allostatic load; biobank; biomarker discovery; connectome; data acquisition; epigenomics; genetic information; genetic variant; genome wide association study; healthy aging; inflammatory marker; lipidomics; medical schools; meetings; metabolomics; molecular marker; mullerian-inhibiting hormone; multiple omics; neurofilament; neuroimaging marker; neuroinflammation; novel; novel marker; polygenic risk score; recruit; resilience; risk prediction model; statistics; tau-1; transcriptomics

ABSTRACT FOR GMSC Aging populations worldwide, particularly in developed countries, face an increasing burden of neurodegenerative diseases. Genetic studies have greatly contributed to our understanding of these complex diseases. Now it is clear that studies beyond genetics, such as transcriptomics, proteomics, or epigenomics are needed to fully understand the biology of neurodegeneration and healthy aging, to identify novel biomarkers and identify novel targets. The goal of the Genomics and Multi-omics Specimens core (GMSC) is to obtain, bank and quality control (QC) biospecimens (DNA, RNA and plasma) from AABC participants. The core will generate GWAS, APOE and polygenic risk scores for all participants that will be used by other AABC Projects. We will also generate longitudinal multi-omic (classic blood analytes, anti-Müllerian hormone (AMH), Alzheimer disease (AD) biomarkers, and neuroinflammation proteomics) blood data that will be used for Projects 1-4 to determine biomarker positivity for AD, allosteric load, inflammation, lifestyle behaviors, and the menopausal transition that are instrumental for those projects.

GMSC摘要