THE GENETICS AND MULTI-OMICS SPECIMENS CORE (GMSC)

遗传学和多组学样本核心 (GMSC)

• 批准号: 10673899
• 负责人: Carlos Cruchaga
• 金额: $ 71.63万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673899
• 关键词: Adult; Aged, 80 and over; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Basic Science; Behavior; Bilirubin; Biocompatible Materials; Bioinformatics; Biological; Biological Markers; Biological databases; Biology; Blood; Blood specimen; Brain; Cholesterol; Clinical Chemistry; Clinical Sciences; Clinical assessments; Cognition; Cognitive; Collaborations; Collection; Complex; Creatinine; DNA; DNA Library; DNA Methylation; Data; Data Analyses; Data Collection; Databases; Dementia; Deposition; Developed Countries; Disease; Elderly; Face; Genes; Genetic; Genetic study; Genomics; Genotype; Glial Fibrillary Acidic Protein; Goals; Hormones; Human; Image; Impaired cognition; Individual; Inflammation; Inflammatory; Investigation; Life Style; Light; Liver; Longitudinal Studies; Measurement; Measures; Metabolic; Molecular Disease; Multiomic Data; Nerve Degeneration; Neurodegenerative Disorders; Participant; Perimenopause; Phenotype; Plasma; Population; Procedures; Process; Proteins; Proteomics; Protocols documentation; Psychometrics; Qualifying; Quality Control; RNA; Renal function; Research Personnel; Sampling; Site; Specimen; Standardization; Testing; Time; Tube; Universities; Visit; Washington; aging brain; allostatic load; biobank; biomarker discovery; connectome; data acquisition; data integration; epigenomics; genetic information; genetic variant; genome wide association study; healthy aging; inflammatory marker; lipidomics; medical schools; meetings; metabolomics; molecular marker; mullerian-inhibiting hormone; multiple omics; neurofilament; neuroimaging; neuroinflammation; novel; novel marker; polygenic risk score; recruit; resilience; risk prediction model; statistics; tau-1; transcriptomics

ABSTRACT FOR GMSC Aging populations worldwide, particularly in developed countries, face an increasing burden of neurodegenerative diseases. Genetic studies have greatly contributed to our understanding of these complex diseases. Now it is clear that studies beyond genetics, such as transcriptomics, proteomics, or epigenomics are needed to fully understand the biology of neurodegeneration and healthy aging, to identify novel biomarkers and identify novel targets. The goal of the Genomics and Multi-omics Specimens core (GMSC) is to obtain, bank and quality control (QC) biospecimens (DNA, RNA and plasma) from AABC participants. The core will generate GWAS, APOE and polygenic risk scores for all participants that will be used by other AABC Projects. We will also generate longitudinal multi-omic (classic blood analytes, anti-Müllerian hormone (AMH), Alzheimer disease (AD) biomarkers, and neuroinflammation proteomics) blood data that will be used for Projects 1-4 to determine biomarker positivity for AD, allosteric load, inflammation, lifestyle behaviors, and the menopausal transition that are instrumental for those projects.

GMSC摘要 全世界，特别是发达国家的老龄化人口面临着越来越大的负担， 神经退行性疾病遗传学研究极大地促进了我们对这些复杂的 疾病现在很明显，遗传学以外的研究，如转录组学，蛋白质组学或表观基因组学， 需要充分了解神经变性和健康衰老的生物学，以确定新的生物标志物， 确定新目标。基因组学和多组学标本核心（GMSC）的目标是获得，储存和 来自AABC参与者的质量控制（QC）生物标本（DNA、RNA和血浆）。核心会产生 其他AABC项目将使用的所有参与者的GWAS、APOE和多基因风险评分。我们将 还生成纵向多组学（经典血液分析物、抗苗勒管激素（AMH）、阿尔茨海默病 (AD)生物标志物和神经炎症蛋白质组学）血液数据，将用于项目1-4以确定 AD的生物标志物阳性、变构负荷、炎症、生活方式行为和 对这些项目都有帮助。