THE INTEGRATED DATA ACQUISITION CORE (IDAC)

IDAC摘要 老龄成人脑连接组(AABC)项目的集成数据采集核心(IDAC)将获得 寿命-HCP-老龄化(HCP-A)队列中的高质量纵向数据，目的是研究脆弱性 以及对衰老的适应能力。这些数据将支持发现衰老的拐点，以及这些拐点如何与 已确定的阿尔茨海默病(AD)或其他AD相关痴呆(ADRD)的风险/恢复能力的生物标志物。 我们将使用HCP收购模式，并在HCP-A研究的多地点联合体的基础上建立，该研究已 获得性神经成像和广泛的非成像表型数据来自一个大的横断面和 典型老年成年人的纵向样本。AABC项目对脆弱性和复原力的关注将 通过无与伦比的数据集增强HCP-A，每个人拥有长达10年的纵向数据，并进行采样 覆盖了1000名参与者的整个老龄化范围。这一全面的数据集具有巨大的潜力 与AD/ADRD风险增加相关的早期标志物和行为。为了实现这一目标， IDAC将扩展和监督神经成像数据的多点纵向收集(3T)、行为数据、 神经认知、生活方式和其他非成像数据，以及来自之前参与者的生物样本 HCP-A该数据集与HCP-A的连续性将允许对主要因素进行丰富的纵向表征 与一般健康和脑老化有关，包括大脑形态测量、结构和功能连接学、 认知、记忆、遗传状态、全身健康、生活方式和荷尔蒙状态。与本组织的目标相关 我们将收集有关压力、社会/社区参与和逆境的新数据，并增强 招募任职人数不足的群体。使用状态来客观衡量睡眠质量和体力活动- 还增加了最先进的可穿戴技术。最后，高场(7T)磁共振波谱(MRS) 将在两个地点增加收购(在临床扫描仪上)，以支持以下创新项目假设 整个生命周期的神经化学变化，以及它们可能如何与其他AD/ADRD风险因素相关。我们的 具体目标是：(1)在两个地点的四个地点实施和监督统一的3T磁共振数据采集 年龄在36-100岁以上的典型老龄化个体的纵向时间点(相隔约2年)，代表 美国的性别、种族和族裔以及社会经济地位；(2)实施和监督7T MRS for 神经化学概况；以及(3)确保适当收集神经心理、行为、生理和 生活方式数据，以及四个地点的生物样本。国际开发咨询委员会将与以下各方面密切合作 AABC-包括其四个相互关联的项目，行政核心，信息学，数据分析， 和统计核心(IDASC)以及遗传学和多组学样本核心(GMSC)--确保一致 跨时间和跨站点的数据采集，从而减少协议漂移和特定站点差异的影响。 总之，国际开发咨询委员会将为这些项目的脆弱性调查和 AABC中的复原力以及各种措施的寿命轨迹如何与AD/ADRD的风险因素相关。

ABSTRACT FOR IDAC The Integrated Data Acquisition Core (IDAC) of the Aging Adult Brain Connectome (AABC) project will acquire high-quality longitudinal data in the lifespan HCP-Aging (HCP-A) cohort, with the goal of studying vulnerability and resilience in aging. The data will support the discovery of inflection points in aging and how those relate to established biomarkers of risk/resilience for Alzheimer’s Disease (AD) or other AD related dementias (ADRD). We will use the HCP acquisition model and build off the multi-site consortium of the HCP-A study, which has acquired neuroimaging and extensive non-imaging phenotyping data from a large cross-sectional and longitudinal sample of typical aging adults. The focus on vulnerability and resilience in the AABC project will potentiate the HCP-A with an unparalleled dataset with up to 10 years of longitudinal data per individual, sampled across the full aging spectrum for 1000 participants. This comprehensive dataset has great potential to uncover early markers and behaviors that are associated with an increased risk for AD/ADRD. To accomplish this goal, the IDAC will extend and oversee multi-site longitudinal collection of neuroimaging data (at 3T), behavioral, neurocognitive, lifestyle and other non-imaging data, and biological samples from previous participants in the HCP-A. The continuity of this dataset with HCP-A will allow for rich longitudinal characterization of major factors relevant to general health and brain aging, including brain morphometry, structural and functional connectomics, cognition, memory, genetic status, systemic health, lifestyle, and hormonal status. Pertinent to the goals of the Projects we will collect new data on stress, social/community engagement, and adversity, with enhanced recruitment of under-represented groups. Objective measures of sleep quality and physical activity using state- of-the-art wearable technology are also added. Finally, high field (7T) magnetic resonance spectroscopy (MRS) acquisitions (on clinical scanners) will be added at two sites, to support innovative Project hypotheses regarding neurochemical changes across the lifespan and how they might correlate with other AD/ADRD risk factors. Our specific aims are to: (1) implement and oversee harmonized 3T MRI data acquisition across the four sites at two longitudinal time points (~2 years apart) in ‘typically-aging’ individuals aged 36-100+ years old, representative of sex, race and ethnicity, and socio-economic status of the US; (2) implement and oversee 7T MRS for neurochemical profiling; and (3) ensure proper collection of neuropsychological, behavioral, physiological and lifestyle data, and biological samples across the four sites. The IDAC will work closely with all other aspects of the AABC – including its four interconnected Projects, the Administrative Core, the Informatics, Data Analysis, and Statistics Core (IDASC), and the Genetics and Multi-omics Specimens Core (GMSC) – to ensure consistent data acquisition across time and sites, thus reducing the impact of protocol drift and site-specific variance. Altogether, the IDAC will provide the foundational data for the Projects’ investigations of vulnerability and resilience in the AABC and how the lifespan trajectory of various measures relates to risk factors for AD/ADRD.