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Adult Age-differences in Auditory Selective Attention: The Interplay of Norepinephrine and Rhythmic Neural Activity

成人听觉选择性注意的年龄差异：去甲肾上腺素与节律神经活动的相互作用

基本信息

批准号：
369385245
负责人：
Dr. Myriam Brandmaier
金额：
--
依托单位：
Davis School of Gerontology
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2017
资助国家：
德国
起止时间：
2016-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/369385245?language=en
关键词：
Adult Age differences Auditory Selective

项目摘要

Selective attention refers to the ability to focus on a subset of the available external (i.e., sensory) and / or internal information (e.g., thoughts, emotions, memories). Therefore, it is a crucial component of successful goal-directed behavior in daily live. For example, participating in a conversation with multiple nearby speakers, e.g., during a party or in a restaurant, requires focusing on the currently relevant interaction partner while simultaneously ignoring interfering voices. However, with advancing age deficits in selective attention become prevalent and can impair daily social interactions. On a neurophysiological level, modulation of attention is linked to the functionality of both the noradrenergic system as well as rhythmic neural activity in the alpha-frequency range (~ 10 Hz). While evidence has accumulated about their functional significance in isolation, much less is known about their interplay. Crucially, both the noradrenergic system and rhythmic neural alpha-activity reveal alterations with advancing age. Hence, building on recent empirical observations and theoretical advancements, we propose a multimodal assessment of both, namely the structural and functional integrity of the central noradrenergic system (via neuromelanin-sensitive magnetic resonance imaging (MRI) and pupillometry, respectively) as well as the functional integrity of rhythmic neural activity (via electroencephalography [EEG]) in the alpha frequency range. Ultimately, we will integrate multiple levels of analysis to foster a mechanistic understanding of age-related declines in selective attention by revealing the interplay between the noradrenergic system and rhythmic neural activity.

选择性注意是指专注于可用的外部（如感官）和/或内部信息（如思想、情感、记忆）的一个子集的能力。因此，它是日常生活中成功的目标导向行为的关键组成部分。例如，在聚会或餐馆中，与附近的多个说话者进行对话，需要专注于当前相关的互动伙伴，同时忽略干扰声音。然而，随着年龄的增长，选择性注意力的缺陷变得普遍，并可能损害日常的社会交往。在神经生理学水平上，注意力的调节与去甲肾上腺素能系统的功能以及α -频率范围（~ 10 Hz）的节律性神经活动有关。虽然已经积累了关于它们单独的功能意义的证据，但对它们的相互作用所知甚少。至关重要的是，去甲肾上腺素能系统和节律性神经α活动都显示出随着年龄的增长而发生的变化。因此，基于最近的经验观察和理论进展，我们提出了一种多模式评估方法，即中枢去甲肾上腺素能系统的结构和功能完整性（分别通过神经黑色素敏感磁共振成像（MRI）和瞳孔测量法）以及α频率范围内节律性神经活动的功能完整性（通过脑电图[EEG]）。最后，我们将整合多个层面的分析，通过揭示去肾上腺素能系统和节律性神经活动之间的相互作用，促进对年龄相关的选择性注意力下降的机制理解。