Biostatistics, Epidemiology, and Research Design Core

生物统计学、流行病学和研究设计核心

• 批准号: 10281545
• 负责人: EARL Shigemi HISHINUMA
• 金额: $ 54.31万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10281545
• 关键词: Address; Adoption; Affect; Area; Biometry; Burn injury; Chronic; Clinical Research; Collaborations; Communication; Communities; Community Outreach; Cost Effectiveness Analysis; Custom; Data; Data Analyses; Data Collection; Data Science; Development; Education; Effectiveness; Environment; Evaluation; Extramural Activities; Filipino; Fostering; Funding; Goals; Grant; Hawaii; Head; Health; Health Policy; Health Services Research; Health Status; Health behavior; Healthcare; Healthy People 2020; Human Resources; Indigenous; Institutionalization; Intervention; Knowledge; Mentors; Methodology; Methods; Morbidity - disease rate; Native Hawaiian; Pacific Island Americans; Participant; Pilot Projects; Play; Population; Preparation; Process; Productivity; Psychiatry; Psychometrics; Publications; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Resources; Role; Science; Secure; Services; Talents; Training; Training and Education; Translational Research; Triad Acrylic Resin; Underserved Population; United States Dept. of Health and Human Services; Universities; Visualization; Vulnerable Populations; Work; career; clinically relevant; community engagement; design; economic evaluation; efficacy trial; epidemiology study; health disparity; health economics; improved; innovation; large datasets; medical schools; medically underserved population; minority health; mortality; novel; outreach program; professor; programs; racial and ethnic disparities; recruit; research and development; skills; social health determinants; stem; tool

Substantial gaps in methodological and statistical support undermine the conduct of scientifically rigorous and culturally responsive clinical and translational research (CTR), especially at the translational Stage T3 to T5. To fill these gaps, the Biostatistics, Epidemiology, and Research Design (BERD) Core will feature seven distinct components: Biostatistics, Epidemiology, Research Design, Data Science, Psychometrics, Mixed Methods, and Economic Analysis. BERD Core’s objective will be to provide resources and strengthen the skills of junior investigators (JI) and established investigators transitioning to CTR in conducting well-designed CTR that reduce the health disparities affecting Indigenous Pacific Peoples (IPP), defined as Native Hawaiians, Other Pacific Islanders, Filipinos, and other medically underserved and vulnerable populations in Hawaii. Specific Aim 1: Provide customized services for the design and analysis of health-disparities CTR by optimizing the use of BERD Core services through leveraging of existing resources and implementing an effective operational plan that recruits appropriate personnel, publicizes resources, and assists users; by assisting investigators in capturing appropriate valid data; by supporting investigators in developing comprehensive, high-quality, unbiased, efficient, reliable, and culturally responsive study designs, including those that address bias in methodology; and by prioritizing support for IPP health-disparities CTR, particularly trials of efficacy (T3) and effectiveness (T4) and adoption and institutionalization (T5). Specific Aim 2: Provide education and training on health-disparities CTR methodologies by mentoring JI/EI in the use of BERD tools and methods appropriate to CTR; by fostering and facilitating environments conducive to career enhancement, emphasizing the preparation and submission of meritorious research proposals by JI/EI, especially those of IPP descent; by designing and promoting an academic- engagement program on research methods and processes; and by creating and promoting a novel outreach program to provide support, mentoring, and education on study design, data analysis, and communication to community partners. Specific Aim 3: Develop tools and methods that maximize the quality of health-disparities CTR by establishing/integrating research designs and biostatistics essential to CTR; by creating design and analysis plans for studies of unique, underserved, or vulnerable populations; by advancing design and analysis plans for studies of small numbers of participants; and developing innovative methods to enhance statistical power. By the end of 5 years, the BERD Core will advance the CTR careers of junior investigators and other transitioning investigators, especially those with IPP backgrounds by supporting their efforts to secure federal funding to conduct independent research aimed at improving the health of IPP and other underserved and vulnerable populations in Hawaii.

在方法和统计支持方面的巨大差距妨碍了科学严谨的 和文化响应的临床和转化研究（CTR），特别是在转化阶段T3， T5为了填补这些空白，生物统计学，流行病学和研究设计（BERD）核心将包括七个 不同的组成部分：生物统计学，流行病学，研究设计，数据科学，心理测量学，混合 方法和经济分析。BERD核心的目标是提供资源和加强技能， 初级研究者（JI）和资深研究者在进行精心设计的CTR时过渡到CTR 减少影响被定义为夏威夷土著人的太平洋土著人民（IPP）的健康差距， 其他太平洋岛民、菲律宾人和夏威夷其他医疗服务不足和弱势群体。 具体目标1：为设计和分析健康差距提供定制服务 通过利用现有资源和实施 有效的运营计划，招募适当的人员，公布资源，并协助用户; 协助研究者获取适当的有效数据;通过支持研究者开发 全面、高质量、无偏见、高效、可靠和文化响应的研究设计，包括 那些解决方法上的偏见的方法;以及通过优先支持土著人民的健康差异CTR，特别是 功效试验（T3）和有效性试验（T4）以及采用和制度化试验（T5）。 具体目标2：通过以下方式提供关于健康差距减少技术转移方法的教育和培训： 指导联合执行/环境倡议使用适合合作减少风险的对外关系与发展工具和方法; 有利于职业发展的环境，强调准备和提交有价值的 联合执行/教育研究所的研究提案，特别是土著人民后裔的提案;设计和促进一个学术- 研究方法和过程的参与计划;并通过创建和促进一个新的外联 该计划旨在提供研究设计、数据分析和沟通方面的支持、指导和教育， 社区合作伙伴。 具体目标3：开发工具和方法，最大限度地提高健康差距的质量， 建立/整合CTR所必需的研究设计和生物统计学;通过创建设计和分析 对独特的、服务不足的或弱势群体的研究计划;通过推进设计和分析计划 为少数参与者开展研究;以及开发创新方法以提高统计能力。 到5年结束时，BERD核心将推进初级调查员和其他 过渡调查人员，特别是那些与IPP背景，支持他们的努力，以确保联邦 资助进行独立研究，旨在改善IPP和其他服务不足的人的健康， 夏威夷的弱势群体。