Request for an Olympus VS200 slide scanner

索取奥林巴斯 VS200 玻片扫描仪

基本信息

  • 批准号:
    10280468
  • 负责人:
  • 金额:
    $ 37.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-01 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

This request is for funds to purchase an Olympus VS200 slide scanner with a multislide feeder and a storage server to hold data generated by the system. This instrument is being requested by a group of NIMH funded investigators who have a significant need to scan many hundreds of slides at high resolution in both brightfield and fluorescent modalities. The device will be housed within the Center for Biologic Imaging (CBI) at the University of Pittsburgh School of Medicine. The mandate of this core facility is to provide access to a full range of light and electron optical, image analysis, and morphometric methods to all research groups within the University of Pittsburgh School of Medicine. To gain a full and quantitative appreciation of the distribution of proteins and active genes within the central nervous system it is no longer sufficient to scan by eye and collect snapshot images that guide science as this commonly introduces bias and is certainly not appropriate when protein expression is at low levels or expressed in very discrete locations throughout brain regions. Rather there is a pressing and prevalent need to analyze distributions in 3D, commonly over many sections and over large areas. The investigators in this proposal have been using the “home brew” solutions available within the CBI. While these devices may have the spatial and spectral sensitivity to meet the needs of the investigative team they need to be tended to throughout the imaging to select image regions, add oil or change slides and are also being used by the very large number of investigators who are actively working with the CBI systems. Therefore, there is a single prime reason for this application: to provide critically needed high quality, automated instrument time to the NIMH supported users of the Center for Biologic Imaging. Since the CBI commenced operations 28 years ago, it has become an integral part of the medical research community currently participating in research projects with more than 300 PHS funded groups within the medical area, as well as in PHS supported projects with investigators in other departments and at neighboring institutions. The NIMH funded user base within the institution continues to grow and its requirement for large area automated imaging continues to expand. The lack of available scanning time has become a major limiting factor in the utility of the CBI to this specific group of users which has led to considerable frustration, as progress in funded work is absolutely dependent on high quality quantitative molecular anatomy of brain sections. The acquisition of an automated slide scanning microscope specifically for this user group will be a tremendous addition to the activity and functionality of the center as it will alleviate access on pre-existing systems for other user groups and will help alleviate the current user bottle neck for high resolution slide scanning by our NIMH funded colleagues.
本申请是为购买带有多片给料机的奥林巴斯VS200滑动扫描仪而申请的资金

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KENNETH N FISH其他文献

KENNETH N FISH的其他文献

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{{ truncateString('KENNETH N FISH', 18)}}的其他基金

Deciphering the GABA neuron alterations in schizophrenia
破译精神分裂症中 GABA 神经元的改变
  • 批准号:
    9761684
  • 财政年份:
    2019
  • 资助金额:
    $ 37.04万
  • 项目类别:
Deciphering the GABA neuron alterations in schizophrenia
破译精神分裂症中 GABA 神经元的改变
  • 批准号:
    9890003
  • 财政年份:
    2019
  • 资助金额:
    $ 37.04万
  • 项目类别:
Deciphering the GABA neuron alterations in schizophrenia
破译精神分裂症中 GABA 神经元的改变
  • 批准号:
    10323264
  • 财政年份:
    2019
  • 资助金额:
    $ 37.04万
  • 项目类别:
Deciphering the GABA neuron alterations in schizophrenia
破译精神分裂症中 GABA 神经元的改变
  • 批准号:
    10545717
  • 财政年份:
    2019
  • 资助金额:
    $ 37.04万
  • 项目类别:
Chandelier cell inputs to pyramidal neurons in schizophrenia and development
精神分裂症和发育过程中吊灯细胞对锥体神经元的输入
  • 批准号:
    8439885
  • 财政年份:
    2012
  • 资助金额:
    $ 37.04万
  • 项目类别:
Chandelier cell inputs to pyramidal neurons in schizophrenia and development
精神分裂症和发育过程中吊灯细胞对锥体神经元的输入
  • 批准号:
    8690618
  • 财政年份:
    2012
  • 资助金额:
    $ 37.04万
  • 项目类别:
Chandelier cell inputs to pyramidal neurons in schizophrenia and development
精神分裂症和发育过程中吊灯细胞对锥体神经元的输入
  • 批准号:
    8538506
  • 财政年份:
    2012
  • 资助金额:
    $ 37.04万
  • 项目类别:
Chandelier cell inputs to pyramidal neurons in schizophrenia and development
精神分裂症和发育过程中吊灯细胞对锥体神经元的输入
  • 批准号:
    8879213
  • 财政年份:
    2012
  • 资助金额:
    $ 37.04万
  • 项目类别:
Differential Terminal Expression of GAD67/GAD65 ? Relevance to Schizophrenia
GAD67/GAD65 的差异末端表达?
  • 批准号:
    7569786
  • 财政年份:
    2009
  • 资助金额:
    $ 37.04万
  • 项目类别:
Differential Terminal Expression of GAD67/GAD65 ? Relevance to Schizophrenia
GAD67/GAD65 的差异末端表达?
  • 批准号:
    7802980
  • 财政年份:
    2009
  • 资助金额:
    $ 37.04万
  • 项目类别:

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