Postoperative Telehealth Mindfulness Intervention to Improve Pain-related Outcomes and Reduce Opioid Use after Lumbar Spine Surgery
术后远程医疗正念干预可改善腰椎手术后疼痛相关的结果并减少阿片类药物的使用
基本信息
- 批准号:10283807
- 负责人:
- 金额:$ 12.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcademic Medical CentersAddressAdultAffectAgeAnxietyAreaAwardBehavior TherapyBeliefClinical InvestigatorClinical ResearchClinical TrialsClinical Trials DesignComplexDataData AnalysesData CollectionDevelopmentEducationEnrollmentFeedbackFutureGoalsGrantGrowthHomeHourIndividualInformation DisseminationInfrastructureInterventionIntervention StudiesIntervention TrialInterviewKnowledgeMeasuresMental DepressionMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMethodologyMethodsMind-Body InterventionNeuronal PlasticityOperative Surgical ProceduresOpioidOrthopedic SurgeryOrthopedicsOutcomePainPain MeasurementPain intensityPain interferencePain managementParticipantPatient Outcomes AssessmentsPatientsPersistent painPersonsPhysical FunctionPopulationPostoperative PainPostoperative PeriodPractice ManagementPrediction of Response to TherapyProceduresProspective StudiesProtocols documentationPsychophysicsPsychosocial FactorPublic HealthQuality of lifeRandomizedRandomized Clinical TrialsRandomized Controlled TrialsRecoveryReportingResearchResearch Project GrantsResearch TrainingResourcesRisk FactorsScienceSelf EfficacySpine painSpine surgeryStructureSurveysSystemTestingTimeTrainingTreatment outcomeUnited StatesVertebral columnWorkWritingacceptability and feasibilityarmbasebiopsychosocialcareercareer developmentcentral sensitizationchronic painclinically relevantcomparison interventiondesigndisabilityemotional distressexperiencegroup interventionhigh riskimprovedimproved functioningintervention participantslearning strategymeetingsmindfulnessmindfulness interventionmultidisciplinarynegative affectonline deliveryopioid epidemicopioid usepain outcomepain processingpain sensitivitypatient orientedpatient populationpatient subsetspost interventionprescription opioidprogramspsychological distresspsychosocialsatisfactionskillssurgery outcometelehealth
项目摘要
Modified Project Summary/Abstract Section
This K23 award will support the candidate’s growth toward an independent clinical research career focused on developing and testing psychosocially-oriented mind-body interventions to improve the quality-of-life and treatment outcomes of chronic pain and postsurgical pain populations. Lumbar spine pain affects over 50 million individuals in the United States (US). The rate of spine surgeries performed in the US is the highest in the world. Yet, up to 40% of patients experience poor pain-related, functional, or quality of life outcomes after surgery. Despite the limited efficacy and high risks associated with long term opioid use, up to 50% of patients are prescribed opioids for up to 12 months following lumbar spine surgery. Nonpharmacological approaches addressing psychosocial risk factors for poor post-surgical outcomes are understudied and underutilized during postsurgical recovery. The proposed project aims to 1) adapt and refine a mindfulness-based intervention (MBI) for one-on-one telehealth delivery (live videoconference) to patients recovering from lumbar spine surgery by conducting a preliminary test of the MBI and collecting patient feedback using mixed methods; 2) conduct a two-arm pilot randomized controlled trial (RCT) of the postsurgical telehealth MBI vs. an education control to evaluate the feasibility and acceptability of the interventions and research procedures; and 3) summarize trajectories of pain-related outcomes (pain interference, opioid usage) and treatment targets (pain-related beliefs, mindfulness, psychophysical measures), within intervention groups and within key patient subgroups (levels of preoperative negative affect and opioid use status). The proposal targets career development in several areas: 1) developing and testing mind-body interventions utilizing mixed methods and longitudinal data collection and analysis; 2) randomized clinical trial design and methodology; 3) psychophysical testing of pain modulatory systems; 4) content knowledge in postoperative orthopaedic pain and opioid use; and 5) grant-writing skills. The candidate’s training goals will be achieved with the support of a multidisciplinary team of accomplished mentors and contributors, through targeted course work and seminars, culminating in completion of the proposed research project and dissemination of results. Training will take place in a resource-rich academic medical center with a top-performing surgical center and existing infrastructure for the prospective study of patients undergoing lumbar spine surgery. The findings will help tailor a telehealth MBI for an orthopaedic postsurgical population and provide preliminary data to optimize a well-powered RCT. This K23 award will promote the early career candidate in establishing an independent research program focused on optimizing telehealth mindfulness interventions in postsurgical and pain populations to inform the science and delivery of personalized pain management practices. The goals of this project are strongly aligned with NCCIH scientific priorities to address the widespread burden of chronic pain and the ongoing opioid epidemic.
修改项目摘要/摘要部分
该K23奖项将支持候选人发展独立的临床研究事业,专注于开发和测试以心理社会为导向的身心干预措施,以改善慢性疼痛和术后疼痛人群的生活质量和治疗结果。腰椎疼痛影响美国(US)超过5000万人。美国的脊柱手术率是世界上最高的。然而,高达40%的患者在手术后经历了不良的疼痛相关、功能或生活质量结局。尽管长期使用阿片类药物的疗效有限且风险较高,但高达50%的患者在腰椎手术后接受长达12个月的阿片类药物处方。在术后恢复过程中,针对术后不良结局的心理社会风险因素的非药物方法研究不足且未得到充分利用。拟议的项目旨在1)调整和完善一对一远程医疗服务的正念干预(MBI)通过对MBI进行初步测试并使用混合方法收集患者反馈,对腰椎手术后恢复的患者进行现场视频会议; 2)进行一项两组初步随机对照试验(RCT)手术后远程医疗MBI与教育对照的比较,以评估干预措施和研究程序的可行性和可接受性;和3)总结疼痛相关结果的轨迹(疼痛干扰,阿片类药物使用)和治疗目标(疼痛相关的信念,正念,心理物理测量),在干预组和关键患者亚组(术前负面影响和阿片类药物使用状态的水平)。该提案针对几个领域的职业发展:1)利用混合方法和纵向数据收集和分析开发和测试身心干预措施; 2)随机临床试验设计和方法; 3)疼痛调节系统的心理物理测试; 4)术后骨科疼痛和阿片类药物使用的内容知识;和5)赠款写作技能。候选人的培训目标将通过有针对性的课程和研讨会,在一个由有成就的导师和贡献者组成的多学科团队的支持下实现,最终完成拟议的研究项目并传播成果。培训将在一个资源丰富的学术医疗中心进行,该中心拥有一流的手术中心和现有的基础设施,可对接受腰椎手术的患者进行前瞻性研究。这些发现将有助于为骨科手术后人群量身定制远程医疗MBI,并提供初步数据以优化有效的RCT。该K23奖项将促进早期职业候选人建立一个独立的研究计划,专注于优化手术后和疼痛人群的远程健康正念干预,以告知个性化疼痛管理实践的科学和交付。该项目的目标与NCCIH的科学优先事项高度一致,以解决慢性疼痛和持续阿片类药物流行的广泛负担。
项目成果
期刊论文数量(0)
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Carrie Elizabeth Brintz其他文献
Carrie Elizabeth Brintz的其他文献
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{{ truncateString('Carrie Elizabeth Brintz', 18)}}的其他基金
Postoperative Telehealth Mindfulness Intervention to Improve Pain-related Outcomes and Reduce Opioid Use after Lumbar Spine Surgery
术后远程医疗正念干预可改善腰椎手术后疼痛相关的结果并减少阿片类药物的使用
- 批准号:
10462694 - 财政年份:2021
- 资助金额:
$ 12.61万 - 项目类别:
Postoperative Telehealth Mindfulness Intervention to Improve Pain-related Outcomes and Reduce Opioid Use after Lumbar Spine Surgery
术后远程医疗正念干预可改善腰椎手术后疼痛相关的结果并减少阿片类药物的使用
- 批准号:
10700889 - 财政年份:2021
- 资助金额:
$ 12.61万 - 项目类别:
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