Neural Signatures of Enhanced Central Auditory Gain in Hyperacusis
听觉过敏中枢听觉增益增强的神经特征
基本信息
- 批准号:10285833
- 负责人:
- 金额:$ 4.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:Acoustic NerveAcousticsAddressAdverse reactionsAffectiveAgeAnimal ModelAreaArousalAuditoryAuditory ThresholdAuditory systemBehavioralBiological AssayBiological MarkersCaliberClinicalClinical ResearchCodeDevelopmentDiagnosisDiagnosticDiseaseDistressEarElectroencephalographyElectrophysiology (science)EmotionalEmploymentExhibitsEyeFaceFrightFunctional disorderGalvanic Skin ResponseGeneral PopulationGoalsGrowthHearingHearing problemHeart RateHeterogeneityHyperactivityHyperacusisHypersensitivityIndividualInjuryInterventionInvestigationK-Series Research Career ProgramsLaboratoriesLeadLibrariesLimbic SystemLinkLoudnessLoudness PerceptionMapsMassachusettsMeasuresMentored Research Scientist Development AwardMentorsMentorshipMethodsMonitorMovementMusNegative ValenceNeuraxisOutputPainPatient Self-ReportPatientsPerceptionPeripheralPhysiologicalPlant RootsPrevalencePsychoacousticsPsychophysicsPupilQuality of lifeQuestionnairesReflex actionReportingResearchScientistSecondary toSocial isolationStimulusSymptomsTestingTrainingaccurate diagnosisassociated symptomauditory pathwayavoidance behaviorbehavior measurementclinical diagnosticscomorbiditydeafnesseffective therapyemotional distresshearing impairmenthuman modelhuman subjectnegative affectneurophysiologynormal hearingpsychosocialrelating to nervous systemresponsesocialsoundtool
项目摘要
PROJECT SUMMARY/ABSTRACT
Hyperacusis is a common and debilitating auditory disorder wherein sounds of moderate intensity are described
as unbearably loud, aversive, or even painful. Hyperacusis often has a profoundly negative impact on quality of
life, leading to loss of employment, social isolation, and severe psychiatric co-morbidities. Despite the prevalence
and heterogeneity of self-reported auditory and emotional sequelae secondary to hyperacusis, its
characterization remains largely qualitative. Clinicians lack quantitative and objective neurophysiological
markers that would illuminate the neural basis for hyperacusis and allow accurate diagnosis and surveillance of
psychoacoustic and distress-related symptoms. In this mentored career development award, the Candidate
proposes a training plan to develop objective, non-invasive physiological biomarkers that can quantitatively
dissociate complaints of enhanced loudness perception and sound-evoked distress in individuals with
hyperacusis, and which have the potential to evolve into a new class of clinical diagnostic tools for evaluating
sound intolerance. Supported by decades of research on acoustic injury in animal models, we posit that many
of the sound intolerance symptoms associated with hyperacusis share a common root related to maladaptive
hyperexcitability (i.e., increased gain) in the central auditory and limbic systems. In Aim 1, the Candidate will
implement a battery of perceptual and electroencephalography (EEG) measures to test the hypothesis that
subjects with hyperacusis have steeper electrophysiological sound-level growth in the central auditory system
and heightened loudness perception as compared to age-matched neurotypical controls. In Aim 2, the Candidate
will use complementary behavioral and objective measures of arousal and affective sound quality to test the
hypothesis that individuals with hyperacusis exhibit greater subjective and physiological sound-evoked arousal
(i.e., larger changes in pupil diameter, skin conductance, heart rate, and facial micro-movements) for emotionally
neutral stimuli than age-matched neurotypical controls. The Candidate has assembled a mentorship team of
world-class clinicians and auditory neuroscientists that have expertise in a range of relevant areas for the
proposal including electrophysiological and psychophysical measures of central gain in humans and animal
models. The Eaton-Peabody Laboratories at Massachusetts Eye and Ear is the world’s leading center for the
study of hearing and deafness, allowing ample opportunities for research and professional development. The
K01 award will allow the Candidate to reshape the reach and sophistication of the clinical research questions
that she can pursue, providing a crucial stepping-stone toward her goal of developing into an independent
clinician-scientist.
项目总结/文摘
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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专利数量(0)
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Kelly Nicole Jahn其他文献
Kelly Nicole Jahn的其他文献
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{{ truncateString('Kelly Nicole Jahn', 18)}}的其他基金
Neural Signatures of Enhanced Central Auditory Gain in Hyperacusis
听觉过敏中枢听觉增益增强的神经特征
- 批准号:
10627967 - 财政年份:2021
- 资助金额:
$ 4.6万 - 项目类别:
Neural Signatures of Enhanced Central Auditory Gain in Hyperacusis
听觉过敏中枢听觉增益增强的神经特征
- 批准号:
10456238 - 财政年份:2021
- 资助金额:
$ 4.6万 - 项目类别:
Neural Signatures of Enhanced Central Auditory Gain in Hyperacusis
听觉过敏中枢听觉增益增强的神经特征
- 批准号:
10534580 - 财政年份:2021
- 资助金额:
$ 4.6万 - 项目类别:
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