Neural Signatures of Enhanced Central Auditory Gain in Hyperacusis

听觉过敏中枢听觉增益增强的神经特征

• 批准号: 10285833
• 负责人: Kelly Nicole Jahn
• 金额: $ 4.6万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285833
• 关键词: Acoustic Nerve; Acoustics; Address; Adverse reactions; Affective; Age; Animal Model; Area; Arousal; Auditory; Auditory Threshold; Auditory system; Behavioral; Biological Assay; Biological Markers; Caliber; Clinical; Clinical Research; Code; Development; Diagnosis; Diagnostic; Disease; Distress; Ear; Electroencephalography; Electrophysiology (science); Emotional; Employment; Exhibits; Eye; Face; Fright; Functional disorder; Galvanic Skin Response; General Population; Goals; Growth; Hearing; Hearing problem; Heart Rate; Heterogeneity; Hyperactivity; Hyperacusis; Hypersensitivity; Individual; Injury; Intervention; Investigation; K-Series Research Career Programs; Laboratories; Lead; Libraries; Limbic System; Link; Loudness; Loudness Perception; Maps; Massachusetts; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Monitor; Movement; Mus; Negative Valence; Neuraxis; Output; Pain; Patient Self-Report; Patients; Perception; Peripheral; Physiological; Plant Roots; Prevalence; Psychoacoustics; Psychophysics; Pupil; Quality of life; Questionnaires; Reflex action; Reporting; Research; Scientist; Secondary to; Social isolation; Stimulus; Symptoms; Testing; Training; accurate diagnosis; associated symptom; auditory pathway; avoidance behavior; behavior measurement; clinical diagnostics; comorbidity; deafness; effective therapy; emotional distress; hearing impairment; human model; human subject; negative affect; neurophysiology; normal hearing; psychosocial; relating to nervous system; response; social; sound; tool

PROJECT SUMMARY/ABSTRACT Hyperacusis is a common and debilitating auditory disorder wherein sounds of moderate intensity are described as unbearably loud, aversive, or even painful. Hyperacusis often has a profoundly negative impact on quality of life, leading to loss of employment, social isolation, and severe psychiatric co-morbidities. Despite the prevalence and heterogeneity of self-reported auditory and emotional sequelae secondary to hyperacusis, its characterization remains largely qualitative. Clinicians lack quantitative and objective neurophysiological markers that would illuminate the neural basis for hyperacusis and allow accurate diagnosis and surveillance of psychoacoustic and distress-related symptoms. In this mentored career development award, the Candidate proposes a training plan to develop objective, non-invasive physiological biomarkers that can quantitatively dissociate complaints of enhanced loudness perception and sound-evoked distress in individuals with hyperacusis, and which have the potential to evolve into a new class of clinical diagnostic tools for evaluating sound intolerance. Supported by decades of research on acoustic injury in animal models, we posit that many of the sound intolerance symptoms associated with hyperacusis share a common root related to maladaptive hyperexcitability (i.e., increased gain) in the central auditory and limbic systems. In Aim 1, the Candidate will implement a battery of perceptual and electroencephalography (EEG) measures to test the hypothesis that subjects with hyperacusis have steeper electrophysiological sound-level growth in the central auditory system and heightened loudness perception as compared to age-matched neurotypical controls. In Aim 2, the Candidate will use complementary behavioral and objective measures of arousal and affective sound quality to test the hypothesis that individuals with hyperacusis exhibit greater subjective and physiological sound-evoked arousal (i.e., larger changes in pupil diameter, skin conductance, heart rate, and facial micro-movements) for emotionally neutral stimuli than age-matched neurotypical controls. The Candidate has assembled a mentorship team of world-class clinicians and auditory neuroscientists that have expertise in a range of relevant areas for the proposal including electrophysiological and psychophysical measures of central gain in humans and animal models. The Eaton-Peabody Laboratories at Massachusetts Eye and Ear is the world’s leading center for the study of hearing and deafness, allowing ample opportunities for research and professional development. The K01 award will allow the Candidate to reshape the reach and sophistication of the clinical research questions that she can pursue, providing a crucial stepping-stone toward her goal of developing into an independent clinician-scientist.

项目总结/文摘