Functional neurovascular coupling in a mouse model of Alzheimer's Disease

拟议研究的目标 阿尔茨海默病(AD)是最常见的神经退行性疾病，表现为 进行性和不可逆转的记忆丧失和痴呆症。虽然药物和管理 策略可以暂时改善症状，到目前为止还没有治愈方法。因此，有很高的需求 为阿尔茨海默病的病因、病理条件和行为症状提供可能 预防和治疗。拟议研究的中心目标是确定功能 小鼠齿状回的神经血管偶联及其潜在的神经回路机制 AD的模型。

Goal of Proposed Research Alzheimer’s disease (AD) is the most common neurodegenerative disease, presenting with progressive and irreversible memory loss and dementia. Although medications and management strategies can temporarily improve symptoms, no cure so far exists. Therefore, there is a high demand for underlying the cause, pathological conditions and behavioral symptoms of AD for advancing possible preventions and treatments. The central goal of the proposed research is to determine functional neurovascular coupling of the dentate gyrus and its underlying neural circuit mechanism in a mouse model of AD.