Functional neurovascular coupling in a mouse model of Alzheimer's Disease
阿尔茨海默病小鼠模型中的功能性神经血管耦合
基本信息
- 批准号:10285083
- 负责人:
- 金额:$ 31.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAlzheimer&aposs DiseaseAlzheimer&aposs disease modelBehavioral SymptomsCouplingDementiaDevelopmentDiseaseGoalsHippocampus (Brain)HomeostasisIndividualMedication ManagementMemory LossNervous System TraumaNeurodegenerative DisordersPathologicPreventionPublic HealthResearchResearch ProposalsTraumatic injuryUnited Statesadvanced diseasedentate gyrusimprovedmouse modelneural circuitneurovascular couplingnovel therapeuticssymptomatic improvement
项目摘要
Goal of Proposed Research
Alzheimer’s disease (AD) is the most common neurodegenerative disease, presenting with
progressive and irreversible memory loss and dementia. Although medications and management
strategies can temporarily improve symptoms, no cure so far exists. Therefore, there is a high demand
for underlying the cause, pathological conditions and behavioral symptoms of AD for advancing possible
preventions and treatments. The central goal of the proposed research is to determine functional
neurovascular coupling of the dentate gyrus and its underlying neural circuit mechanism in a mouse
model of AD.
拟研究目标
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Shaoyu Ge其他文献
Shaoyu Ge的其他文献
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{{ truncateString('Shaoyu Ge', 18)}}的其他基金
Examine the local glucose dynamics in activity-induced hippocampal neurogenesis
检查活动诱导的海马神经发生中的局部葡萄糖动态
- 批准号:
10572244 - 财政年份:2022
- 资助金额:
$ 31.56万 - 项目类别:
Mechanistic study of declining hippocampal neurogenesis in the aging brain
衰老大脑海马神经发生下降的机制研究
- 批准号:
10577735 - 财政年份:2020
- 资助金额:
$ 31.56万 - 项目类别:
Mechanistic study of declining hippocampal neurogenesis in the aging brain
衰老大脑海马神经发生下降的机制研究
- 批准号:
10334527 - 财政年份:2020
- 资助金额:
$ 31.56万 - 项目类别:
To explore the development and function of clonally-related adult-born dentate gr
探讨克隆相关的成年齿状细胞的发育和功能
- 批准号:
8772093 - 财政年份:2014
- 资助金额:
$ 31.56万 - 项目类别:
The roles and mechanisms of GABA receptor activation in regulating neurogenesis i
GABA受体激活在调节神经发生中的作用和机制
- 批准号:
8312561 - 财政年份:2009
- 资助金额:
$ 31.56万 - 项目类别:
The roles and mechanisms of GABA receptor activation in regulating neurogenesis i
GABA受体激活在调节神经发生中的作用和机制
- 批准号:
8123112 - 财政年份:2009
- 资助金额:
$ 31.56万 - 项目类别:
The roles and mechanisms of GABA receptor activation in regulating neurogenesis i
GABA受体激活在调节神经发生中的作用和机制
- 批准号:
8531359 - 财政年份:2009
- 资助金额:
$ 31.56万 - 项目类别:
The roles and mechanisms of GABA receptor activation in regulating neurogenesis i
GABA受体激活在调节神经发生中的作用和机制
- 批准号:
7790926 - 财政年份:2009
- 资助金额:
$ 31.56万 - 项目类别: