Functional neurovascular coupling in a mouse model of Alzheimer's Disease

阿尔茨海默病小鼠模型中的功能性神经血管耦合

• 批准号: 10285083
• 负责人: Shaoyu Ge
• 金额: $ 31.56万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10285083
• 关键词: Activities of Daily Living; Alzheimer' s Disease; Alzheimer' s disease model; Behavioral Symptoms; Coupling; Dementia; Development; Disease; Goals; Hippocampus (Brain); Homeostasis; Individual; Medication Management; Memory Loss; Nervous System Trauma; Neurodegenerative Disorders; Pathologic; Prevention; Public Health; Research; Research Proposals; Traumatic injury; United States; advanced disease; dentate gyrus; improved; mouse model; neural circuit; neurovascular coupling; novel therapeutics; symptomatic improvement

Goal of Proposed Research Alzheimer’s disease (AD) is the most common neurodegenerative disease, presenting with progressive and irreversible memory loss and dementia. Although medications and management strategies can temporarily improve symptoms, no cure so far exists. Therefore, there is a high demand for underlying the cause, pathological conditions and behavioral symptoms of AD for advancing possible preventions and treatments. The central goal of the proposed research is to determine functional neurovascular coupling of the dentate gyrus and its underlying neural circuit mechanism in a mouse model of AD.

拟议研究的目标 阿尔茨海默氏病（AD）是最常见的神经退行性疾病，表现 进步和不可逆转的记忆力丧失和痴呆症。尽管药物和管理 策略可以暂时改善症状，到目前为止尚无治愈。因此，需求很高 为了基本的原因，病理状况和AD的行为症状，以提高可能 预防和治疗。拟议研究的核心目标是确定功能 小鼠中齿状回的神经血管耦合及其基础神经元电路机制 AD模型。