Cannabis Nexus Initiative: Cannabis and Heart Rate Variability Study in HBCU Students

Cannabis Nexus 计划：HBCU 学生的大麻和心率变异性研究

• 批准号: 10292002
• 负责人: Larry D Keen
• 金额: $ 43万
• 依托单位: VIRGINIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292002
• 关键词: Address; Advisory Committees; African American; Age; Age of Onset; Area; Autonomic nervous system; Award; Biomedical Research; CNR1 gene; Cannabis; Cardiac; Cardiovascular Diseases; Cardiovascular system; Case Study; Case-Control Studies; Cessation of life; Chronic; Clinical Research; Complex; Data; Dependence; Development; Educational workshop; Equipment and supply inventories; Event; Faculty; Frequencies; Functional disorder; Funding; Future; Gap Junctions; Goals; Grant; Health; Heart; Heart Rate; Historically Black Colleges and Universities; Hospitals; Hour; Individual; International; Interview; Legal; Life; Literature; Manuscripts; Measurement; Measures; Mediating; Mentorship; Mission; Modeling; Myocardial Infarction; National Institute of Drug Abuse; Nerve; Nervous system structure; Neuraxis; Participant; Patient Self-Report; Policies; Prevalence; Process; Psychology; Public Health; Publishing; Regulation; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Rest; Risk; Sampling; Science; Series; Site; Social Perception; Students; Substance abuse problem; Surveys; Tachycardia; Time; Underrepresented Students; United States National Institutes of Health; Universities; Virginia; Writing; biobehavior; cardiovascular health; endogenous cannabinoid system; exogenous cannabinoid; experience; graduate student; heart rate variability; heart rhythm; inflammatory marker; interest; marijuana use; marijuana use disorder; marijuana user; member; minority student; neuropsychiatry; programs; receptor; substance use; symposium; undergraduate student; university student; young adult

Project Summary Given the shifts in social perceptions and legalization efforts relating to cannabis use, it is imperative to determine the complex interplay between cannabis use and cardiovascular health. Researchers have identified an association between cannabis use and cardiovascular events, but no study exists measuring associations between cannabis use frequency and autonomic health in young adults. In addition to addressing this gap in the literature, the current project will look to assess this association in African Americans at a Historically Black College or University (HBCU). In this burgeoning literature, no study has examined the prevalence of Cannabis Use Disorder (CUD) in a sample with more than 15% African Americans, with no published study examining students at a HBCU. The two aims presented in this proposal focus on the cannabis use frequency/quantity and determine differences heart rate variability (HRV) between those with CUD and non-substance use disorder students at Virginia State University, a HBCU in central Virginia. For Specific Aim 1, we plan to use the Daily Sessions, Frequency, Age of Onset and Quantity of Cannabis Use Inventory, in addition to Mini International Neuropsychiatric Interview to determine cannabis use and CUD prevalence. We plan to use a Heart Rhythm Scanner to determine HRV at baseline. In Specific Aim 2, we utilize the Zio Patch to determine differences in 24 hour HRV between those with and without CUD. If awarded, these two specific aims will allow: 1) funding for 5 undergraduate students to participate in biomedical research, 2) give the opportunity for underrepresented students to generate data for conferences and manuscripts 3) directly influence substance use policy at VSU by providing empirically supported inferences on substance use to the Substance Abuse Task Force 4) provide pilot data for future NIH proposals for investigators and their students and 5) inspire other undergraduate students to participate in research via lab workshops and various grant related activities.

项目摘要 鉴于与大麻使用有关的社会看法和合法化努力的转变，必须 确定大麻使用和心血管健康之间的复杂相互作用。研究人员已经确定了 大麻使用与心血管事件之间的关联，但没有研究协会的研究 在大麻使用频率和年轻人的自主健康之间。除了解决这个差距 文献，当前的项目将旨在评估非洲裔美国人在历史上的黑人 大学或大学（HBCU）。在这篇新兴文献中，没有研究检查大麻的流行 在具有超过15％非裔美国人的样本中使用障碍（CUD），没有发表研究 HBCU的学生。 该提案中提出的两个目的侧重于大麻使用频率/数量并确定 患有CUD和非固定使用障碍学生的心率变异性（HRV）的差异 弗吉尼亚州立大学，弗吉尼亚州中部的HBCU。对于特定目标1，我们计划使用日常会议， 频率，发病年龄和大麻使用库存的频率，除了迷你国际 神经精神病学访谈，以确定大麻使用和CUD患病率。我们计划使用心律 扫描仪确定基线时的HRV。在特定的目标2中，我们利用Zio贴片来确定 有和没有CUD的人之间的24小时HRV。 如果获得授予，这两个具体目标将允许：1）为5名本科生提供资金 生物医学研究，2）为代表性不足的学生提供了为会议生成数据的机会 3）通过提供经验支持，直接影响VSU的药物使用政策 对药物滥用毒品使用的推论4）为未来的NIH提案提供试点数据 对于调查人员及其学生以及5）激励其他本科生通过 实验室研讨会和各种与赠款有关的活动。