Cannabis Nexus Initiative: Cannabis and Heart Rate Variability Study in HBCU Students

Cannabis Nexus 计划：HBCU 学生的大麻和心率变异性研究

• 批准号: 10292002
• 负责人: Larry D Keen
• 金额: $ 43万
• 依托单位: VIRGINIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292002
• 关键词: Address; Advisory Committees; African American; Age; Age of Onset; Area; Autonomic nervous system; Award; Biomedical Research; CNR1 gene; Cannabis; Cardiac; Cardiovascular Diseases; Cardiovascular system; Case Study; Case-Control Studies; Cessation of life; Chronic; Clinical Research; Complex; Data; Dependence; Development; Educational workshop; Equipment and supply inventories; Event; Faculty; Frequencies; Functional disorder; Funding; Future; Gap Junctions; Goals; Grant; Health; Heart; Heart Rate; Historically Black Colleges and Universities; Hospitals; Hour; Individual; International; Interview; Legal; Life; Literature; Manuscripts; Measurement; Measures; Mediating; Mentorship; Mission; Modeling; Myocardial Infarction; National Institute of Drug Abuse; Nerve; Nervous system structure; Neuraxis; Participant; Patient Self-Report; Policies; Prevalence; Process; Psychology; Public Health; Publishing; Regulation; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Rest; Risk; Sampling; Science; Series; Site; Social Perception; Students; Substance abuse problem; Surveys; Tachycardia; Time; Underrepresented Students; United States National Institutes of Health; Universities; Virginia; Writing; biobehavior; cardiovascular health; endogenous cannabinoid system; exogenous cannabinoid; experience; graduate student; heart rate variability; heart rhythm; inflammatory marker; interest; marijuana use; marijuana use disorder; marijuana user; member; minority student; neuropsychiatry; programs; receptor; substance use; symposium; undergraduate student; university student; young adult

Project Summary Given the shifts in social perceptions and legalization efforts relating to cannabis use, it is imperative to determine the complex interplay between cannabis use and cardiovascular health. Researchers have identified an association between cannabis use and cardiovascular events, but no study exists measuring associations between cannabis use frequency and autonomic health in young adults. In addition to addressing this gap in the literature, the current project will look to assess this association in African Americans at a Historically Black College or University (HBCU). In this burgeoning literature, no study has examined the prevalence of Cannabis Use Disorder (CUD) in a sample with more than 15% African Americans, with no published study examining students at a HBCU. The two aims presented in this proposal focus on the cannabis use frequency/quantity and determine differences heart rate variability (HRV) between those with CUD and non-substance use disorder students at Virginia State University, a HBCU in central Virginia. For Specific Aim 1, we plan to use the Daily Sessions, Frequency, Age of Onset and Quantity of Cannabis Use Inventory, in addition to Mini International Neuropsychiatric Interview to determine cannabis use and CUD prevalence. We plan to use a Heart Rhythm Scanner to determine HRV at baseline. In Specific Aim 2, we utilize the Zio Patch to determine differences in 24 hour HRV between those with and without CUD. If awarded, these two specific aims will allow: 1) funding for 5 undergraduate students to participate in biomedical research, 2) give the opportunity for underrepresented students to generate data for conferences and manuscripts 3) directly influence substance use policy at VSU by providing empirically supported inferences on substance use to the Substance Abuse Task Force 4) provide pilot data for future NIH proposals for investigators and their students and 5) inspire other undergraduate students to participate in research via lab workshops and various grant related activities.

项目摘要 鉴于社会观念的转变和与大麻使用有关的合法化努力， 确定大麻使用与心血管健康之间复杂的相互作用。研究人员已经确定 大麻使用与心血管事件之间存在关联，但没有研究测量关联 大麻使用频率和年轻人的自主健康之间的关系。除了解决这一差距外， 根据文献，目前的项目将着眼于评估非裔美国人在历史上的黑人中的这种联系。 学院或大学（HBCU）。在这一新兴的文献中，没有研究调查大麻的流行情况。 使用障碍（CUD）的样本超过15%的非洲裔美国人，没有发表的研究检查 学生在HBCU。 本提案中提出的两个目标侧重于大麻使用频率/数量，并确定 不同年龄段的CUD和非物质使用障碍学生之间的心率变异性（HRV）差异 弗吉尼亚州立大学，位于弗吉尼亚州中部的HBCU。对于具体目标1，我们计划使用每日课程， 大麻使用频率、发病年龄和数量清单，以及Mini International 神经精神访谈，以确定大麻使用和CUD患病率。我们计划用心律 扫描仪以确定基线时的HRV。在具体目标2中，我们利用Zio Patch来确定 24小时心率变异性（HRV），有无CUD。 如果获奖，这两个具体目标将允许：1）资助5名本科生参加 生物医学研究，2）为代表性不足的学生提供为会议生成数据的机会 和手稿3）通过提供经验支持直接影响VSU的物质使用政策 向药物滥用特别工作组提交的关于药物使用的推论4）为国家卫生研究院未来的提案提供了试验数据 为研究人员和他们的学生和5）激励其他本科生参与研究，通过 实验室工作坊和各种资助相关活动。