Cannabis Nexus Initiative: Cannabis and Heart Rate Variability Study in HBCU Students

项目摘要 鉴于与大麻使用有关的社会观念和合法化努力的转变，必须 确定大麻使用与心血管健康之间复杂的相互作用。研究人员已经确定 大麻使用和心血管事件之间的联系，但没有研究衡量这种联系 在年轻人中大麻使用频率与自主神经健康之间的关系。除了解决这一差距外， 在文献中，目前的项目将寻求评估非裔美国人在历史上的黑人之间的联系 学院或大学(HBCU)。在这些蓬勃发展的文献中，没有一项研究调查过大麻的流行情况 在一个超过15%的非裔美国人的样本中使用障碍(CUD)，没有公开发表的研究检查 HBCU的学生。 本提案提出的两个目标侧重于大麻的使用频率/数量和确定 CUD与非物质使用障碍学生心率变异性的差异 弗吉尼亚州立大学，位于弗吉尼亚州中部的HBCU。对于特定的目标1，我们计划使用每日会议， 除迷你国际外，大麻使用频率、发病年龄和数量清单 神经精神病学访谈，以确定大麻的使用和CUD的流行率。我们计划使用一种心脏节律 扫描仪以确定基线的心率变异性。在具体目标2中，我们使用Zio Patch来确定 有无CUD患者的24小时心率变异性。 如果获奖，这两个具体目标将允许：1)资助5名本科生参加 生物医学研究，2)为代表不足的学生提供为会议生成数据的机会 和手稿3)通过提供经验支持，直接影响VSU的物质使用政策 向药物滥用特别工作组提供的关于药物使用的推断为NIH未来的提案提供了试点数据 为研究人员和他们的学生提供帮助，并通过以下方式激励其他本科生参与研究 实验室工作坊和各种赠款相关活动。

Project Summary Given the shifts in social perceptions and legalization efforts relating to cannabis use, it is imperative to determine the complex interplay between cannabis use and cardiovascular health. Researchers have identified an association between cannabis use and cardiovascular events, but no study exists measuring associations between cannabis use frequency and autonomic health in young adults. In addition to addressing this gap in the literature, the current project will look to assess this association in African Americans at a Historically Black College or University (HBCU). In this burgeoning literature, no study has examined the prevalence of Cannabis Use Disorder (CUD) in a sample with more than 15% African Americans, with no published study examining students at a HBCU. The two aims presented in this proposal focus on the cannabis use frequency/quantity and determine differences heart rate variability (HRV) between those with CUD and non-substance use disorder students at Virginia State University, a HBCU in central Virginia. For Specific Aim 1, we plan to use the Daily Sessions, Frequency, Age of Onset and Quantity of Cannabis Use Inventory, in addition to Mini International Neuropsychiatric Interview to determine cannabis use and CUD prevalence. We plan to use a Heart Rhythm Scanner to determine HRV at baseline. In Specific Aim 2, we utilize the Zio Patch to determine differences in 24 hour HRV between those with and without CUD. If awarded, these two specific aims will allow: 1) funding for 5 undergraduate students to participate in biomedical research, 2) give the opportunity for underrepresented students to generate data for conferences and manuscripts 3) directly influence substance use policy at VSU by providing empirically supported inferences on substance use to the Substance Abuse Task Force 4) provide pilot data for future NIH proposals for investigators and their students and 5) inspire other undergraduate students to participate in research via lab workshops and various grant related activities.