High Intensity Body-weight Circuit Training Feasibility and Efficacy for Improving Metabolic Profile, Body Composition, and Health-Related Fitness in Middle Aged Persons with Type 2 Diabetes

高强度自重循环训练改善中年 2 型糖尿病患者代谢状况、身体成分和健康相关体能的可行性和功效

• 批准号: 10291611
• 负责人: Brian Kliszczewicz
• 金额: $ 38.04万
• 依托单位: KENNESAW STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10291611
• 关键词: Acute; Adherence; Adult; Aerobic; Aerobic Exercise; Age; American; Applied Research; Biological Markers; Body Composition; Body Weight; Cardiometabolic Disease; Cardiovascular system; Career Choice; Cholesterol; Clinical; Clinical Research; Consumption; Data; Dependence; Developed Countries; Diabetes Mellitus; Diagnosis; Disease; Disease Management; Educational Intervention; Effectiveness; Elderly; Exercise; Exposure to; Glucose; Glycosylated hemoglobin A; Goals; Guidelines; Health; Healthcare Industry; Healthcare Systems; Home; Individual; Insulin; Intervention; Kidney; Knowledge; Measures; Mediating; Metabolic; Movement; Muscle; Muscle Contraction; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Outcome Measure; Pathway interactions; Patient-Focused Outcomes; Patients; Personal Satisfaction; Persons; Physical activity; Physiological; Plasma; Population; Prevalence; Progressive Disease; Public Health; Public Health Applications Research; Quality of life; Recommendation; Research; Research Project Grants; Research Technics; Resistance; SLC2A1 gene; Skeletal Muscle; Strenuous Exercise; Thinness; Time; Training; Training Programs; age related; base; blood glucose regulation; cardiometabolism; cardiovascular fitness; comorbidity; cost effective; diabetic patient; economic cost; effectiveness evaluation; exercise intervention; exercise program; fasting glucose; fitness; glucose tolerance; glucose uptake; group intervention; improved; improved outcome; individual patient; insulin sensitivity; metabolic profile; middle age; novel; pandemic disease; physical inactivity; programs; recruit; relating to nervous system; research study; sedentary; student participation; treatment group

Type II diabetes (T2DM) is a progressive disease that is considered a health pandemic in industrialized nations. Untreated, this disease is associated with several untoward conditions (e.g., cardiovascular, neural, renal, etc.) that worsen with both age and physical inactivity. Pragmatic, cost effective, countermeasures to treat T2DM and slow its progression are urgently needed. Exercise is one such intervention that has been proven to be a successful in treating persons with T2DM; however, commonly prescribed exercise programs (e.g. aerobic activity) fail to incorporate the whole body, or are viewed as too time-consuming (e.g.150-minutes per week) resulting in lower adherence. A variety of high-intensity fitness programs approaches successfully mobilize previously sedentary individuals in a time-efficient fashion; however still fail to incorporate greater quantities of skeletal muscle. Our preliminary data utilizing an at home high intensity bodyweight circuit training (HIBC) program indicate that 1) an accumulated 40-minutes per week of over a 16-week period can be safely undertaken by those with T2DM, and 2) the program benefits fasting glucose, HbA1c, cholesterol, glucose tolerance and lean mass. The HIBC is a home-based intervention that consists of completing as many rounds of the circuit of modified squats (10 repetitions), modified rows (5 repetitions), crunches (10), and modified push- ups (5) over the allotted time (e.g., 5-10minutes). Our long-term goal is to provide a more time- efficient, and effective exercise intervention for persons with T2DM and expand upon the current exercise guidelines and recommendations. In order to achieve these objectives, we will pursue the following two specific aims: Aim 1) Identify the influence of a novel HIBC training program on metabolic biomarkers, body composition, and overall fitness. Aim 2) To compare and contrast the outcome measures of the HIBC intervention to that of a traditional exercise intervention (TEI). The proposed research study will approach these aims by recruiting 82 recently diagnosed middle aged adults with T2DM and divide them into two treatment groups: HIBC (n=41) and TEI (n=41), obtain baseline metabolic, body composition, and fitness measures, then undergo 16-weeks of at home training, then obtain post measures. Upon completion of the proposed research, our expected outcomes are to have determined the feasibility and effectiveness of the HIBC intervention on the metabolic profile, body composition, and fitness markers. Additionally, we also expect HIBC to result in similar, if not greater improvements than those of TEI. Results of this study may provide an effective and appealing exercise intervention for cardiometabolic disease management in adults with T2DM, and have significant clinical and public health applications.

II型糖尿病(T2 DM)是一种进行性疾病，在工业化国家被认为是一种健康大流行。如果得不到治疗，这种疾病会导致多种不适(如心血管、神经、肾脏等)。随着年龄和缺乏运动，这种情况会变得更糟。迫切需要务实、经济、有效的对策来治疗T2 DM并减缓其进展。运动是一种已被证明在治疗T2 DM患者方面成功的干预措施；然而，通常开出的运动计划(例如有氧运动)不能涵盖全身，或者被认为太耗时(例如每周150分钟)，导致依从性较低。各种高强度健身计划的方法成功地以一种省时的方式动员了以前久坐不动的人；然而，仍然无法结合更多的骨骼肌。我们利用家庭高强度体重循环训练(HIBC)计划的初步数据表明，1)T2 DM患者可以安全地进行超过16周的每周40分钟累积训练，2)该计划有益于空腹血糖、糖化血红蛋白、胆固醇、葡萄糖耐量和瘦体重。HIBC是一种基于家庭的干预措施，包括在分配的时间内(例如，5-10分钟)完成尽可能多的修改下蹲(10次重复)、修改排(5次重复)、仰卧起坐(10次)和修改俯卧撑(5次)的循环。我们的长期目标是为T2 DM患者提供更省时、更有效的运动干预，并扩展现有的运动指南和建议。为了实现这些目标，我们将追求以下两个具体目标：目标1)确定新的HIBC训练计划对代谢生物标记物、身体成分和整体健康的影响。目的2)比较HIBC干预与传统运动干预(TEI)的结果指标。这项拟议的研究将通过招募82名新近诊断为T2 DM的中年人来实现这些目标，并将他们分为两组：HIBC组(n=41)和TEI组(n=41)，获得基线代谢、身体成分和体能指标，然后进行为期16周的家庭训练，然后获得岗位措施。在拟议的研究完成后，我们的预期结果将确定HIBC干预对代谢特征、身体成分和健康指标的可行性和有效性。此外，我们还希望重债穷国取得与TEI类似的改善，如果不是更大的话。本研究结果为成人T2 DM患者心脏代谢疾病的管理提供了有效的运动干预手段，具有重要的临床和公共卫生应用价值。