African Tuberculosis Bioinformatics Training Program

项目总结 非洲结核病生物信息学培训计划将是一项合作的教育和能力削减 分子生物学和人类遗传学分部和生物研究中心之间的发展计划。 南非斯泰伦博什大学的形式学和计算生物学。它将包括其他非洲国家 弗雷德·哈钦森癌症研究中心拥有强大生物信息学背景的合作伙伴和美国调查人员 中心和美国国立卫生研究院少数民族健康与健康差距研究所。在D71规划阶段， 将制定一项新的生物信息学课程，重点是结核病(TB)，以及评估标准。 通过适用的机构和国家机构为这些项目开展业务活动和获得批准。此外， 计划补助金将用于计划学员的职业发展活动和教师发展计划。 针对教师和中低收入国家合作伙伴。合作伙伴网络将扩大 在D43资助期间，为每个学生提供一名美国和一名非洲导师。拟议中的培训 该计划将解决缺乏训练有素的具有结核病和其他传染病专业知识的生物信息学家的问题。 我们提出了一个包含统计学、生物信息学和结核病生物学课程的理科硕士课程 紧随其后的是一个由世界级结核病科学家指导的研究项目，对目前的 南部非洲的生物信息学景观。生物信息学的多学科性质包括数学- 数理、统计学、信息技术和生物，很少有学生在所有的组成部分上都很强。CON- 因此，许多生物信息学博士生准备不足。拟议的计划将为 为装备更好的学生提供基础，为未来的传染病创新和领导提供必要的支持 研究。将开发的硕士课程将包括为期6个月的讲座模块(主题包括统计， 生物信息学和结核病生物学)。学员随后将被安排在SU主办实验室工作2个月， 随后参观了一位美国东道主的实验室。受训者将专注于他们的研究项目 学位期间的剩余时间。在D71规划阶段，一套 将开展职业发展活动，促进学生成为独立的科学工作者。 是乳房。此外，通过与南非历史上处于不利地位的机构的合作伙伴进行协商， 与其他LMIC合作伙伴合作，将制定一项定制讲习班计划，以加强监督和人员- 托林容量。规划阶段的一个重要重点将是制定监测和评价 计划。总而言之，拟议的工作将把结核病研究人员、生物信息学家和 CIANS、美国导师和LMIC合作伙伴开发以结核病为重点的生物信息学培训计划，以使INFEC- 关于疾病的研究。

PROJECT SUMMARY The African Tuberculosis Bioinformatics Training Program will be a collaborative educational and capacity de- velopment program between the Division of Molecular Biology and Human Genetics, and the Centre for Bioin- formatics and Computational Biology at Stellenbosch University (SU), South Africa. It will include other African partners and US investigators with strong bioinformatics background from the Fred Hutchinson Cancer Research Center and the National Institute on Minority Health and Health Disparities, NIH. During the D71 planning phase, a new Bioinformatics curriculum with emphasis on tuberculosis (TB), along with evaluation criteria, will be devel- oped and approvals obtained for these through the applicable institutional and national bodies. In addition, the planning grant will be used to plan career development activities for trainees and faculty development initiatives for preceptors and low- and middle-income country (LMIC) partners. The network of partners will be expanded to provide one US and one African mentor for each student during the D43 funding. The proposed Training Program will address a dearth of trained bioinformaticians with expertise in TB and other infectious diseases. We propose a MSc program with a vigorous coursework component in statistics, bioinformatics and TB biology followed by a research project mentored by world-class TB scientists to make the biggest impact on the current bioinformatics landscape in Southern Africa. The multidisciplinary nature of bioinformatics encompasses math- ematics, statistics, information technology and biology, and few students are strong in all the components. Con- sequently, many doctoral candidates in bioinformatics are poorly prepared. The proposed program will lay the foundation for better-equipped students necessary for future innovation and leadership in infectious disease research. The MSc program to be developed will include a 6-month lecture block (with topics including Statistics, Bioinformatics and TB Biology). Trainees will then be embedded within the SU host laboratory for 2 months, followed by a visit to the laboratory of a US-based host. The trainees will focus on their research project for the remainder of the degree period. During the D71 planning phase, the content and evaluation criteria for a suite of Career Development Activities will be developed to foster the development of students into independent scien- tists. Further, through consultation with partners in historically disadvantaged institutions in South Africa and other LMIC partners, a program of customized workshops will be developed to strengthen supervisory and men- toring capacity. An important focus of the planning phase will be the development of a monitoring and evaluation plan. In summary, the proposed work will bring together a productive network of TB researchers, bioinformati- cians, US mentors and LMIC partners to develop a TB-focused bioinformatics training program to benefit infec- tious disease research.