Novel actions of neurosteroids on GABA (A) receptor trafficking

神经类固醇对 GABA (A) 受体运输的新作用

• 批准号: 10290964
• 负责人: Paul Andrew Davies
• 金额: $ 5.38万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10290964
• 关键词: Biochemistry; Classification; Communities; Development; Drug Industry; Electrophysiology (science); Exposure to; Fellowship; First Generation College Students; Funding; Future; GABA-A Receptor; Grant; Guam; Guamanian; Industry Collaboration; Learning; Mediating; Membrane; Mentorship; Methodology; Mosses; National Research Service Awards; Neurosciences; Neurosciences Research; Play; Publications; Regulation; Research Personnel; Role; Science; Supervision; Techniques; Training; Universities; Work; Writing; career; design; doctoral student; experimental study; graduate student; neurosteroids; novel; parent grant; pre-doctoral; rural area; skills; trafficking

Project Summary This application is for a diversity supplement to the R01 NS108378, entitled “Novel actions of neurosteroids on GABAAR trafficking” the PIs of which are Dr. Paul Davies and Dr. Stephen Moss at Tufts University. The diversity candidate is Noell, a beginning pre-doctoral student in the lab of Dr. Moss. Noell qualifies as a diversity candidate due to Guamanian classification and being a first-generation college graduate having grown up in Guam, a U.S. rural area. This supplement is to fund Noell’s first years in the lab for her to: 1) receive mentorship and training to advance in pursuit of a career in science, 2) work on preliminary experiments to submit a NRSA F31 fellowship. Dr. Stephen Moss has trained 20 graduate students, many whom are independent investigators, and has a well-respected track record of mentorship. Noell’s project is directly related to aims of the parent grant, which centers on the role that neurosteriods play in mediating the phospho-dependent regulation of GABAAR membrane trafficking. To do this, she will learn and apply techniques in electrophysiology and biochemistry. Overall, this project will give Noell broad exposure to contemporary methodologies used in “cutting edge” neuroscience research and prepare her for a career as an independent investigator. Other mentorship interactions between Noell and Dr. Moss funded by the supplement include building presentation skills, writing grants and scientific publications, ability to design experiments, exposure to the field through invited speakers, and interactions with pharmaceutical industry collaborators. The funding will importantly provide Noell with enrichment opportunities so she can connect with others in the broader neuroscience community. The diversity supplement will bridge Noell’s path towards a positive future in science and continue to build diversity at Tuft’s University. The activities in mentorship and enrichment made possible will be critical in Noell’s development as an independent investigator.

项目摘要 本申请是对R01 NS 108378的多样性补充，标题为“ 神经类固醇对GABAAR贩运”的PI是保罗戴维斯博士和斯蒂芬莫斯博士 在塔夫茨大学多样性的候选人是诺埃尔，一个开始在实验室的博士预科生， 博士莫斯诺埃尔有资格作为一个多样性的候选人，由于关岛的分类和作为一个 第一代大学毕业生在关岛，美国农村地区长大。本补充 资助Noell在实验室的第一年，让她：1）接受指导和培训， 追求科学事业，2）进行初步实验，以提交NRSA F31 奖学金。斯蒂芬·莫斯博士已经培训了20名研究生，其中许多人是独立的 调查员，并有一个备受尊敬的跟踪记录的导师。Noell的项目直接 与父母补助金的目的有关，其中心是神经类固醇在调解中发挥的作用， GABAAR膜运输的磷酸依赖性调节。为了做到这一点，她将学习 并应用电生理学和生物化学技术。总的来说，这个项目将给诺埃尔 广泛接触用于“尖端”神经科学研究的当代方法 为她将来成为独立调查员做好准备其他辅导互动 诺埃尔和莫斯博士之间的补充资助包括建立演讲技巧，写作， 赠款和科学出版物，设计实验的能力，通过 邀请演讲者，并与制药行业合作者互动。这笔资金将 重要的是，为诺埃尔提供丰富的机会，使她能够与其他人联系， 更广泛的神经科学社区。多样性补充将桥梁诺埃尔的道路上， 积极的科学未来，并继续在塔夫特大学建立多样性。的活动 导师和丰富的可能将是至关重要的诺埃尔的发展， 独立调查员