Individual Differences in Dementia Spousal Caregiver Burden: A Biobehavioral Approach

摘要 父母项目的目标是了解哪些AD配偶照顾者最容易受到 配偶痴呆症对身体健康的有害影响， 在承受丧亲之痛的同时，还要努力保持生活质量。作为一个探索性的目标， 我们将研究这些依恋取向的个体如何影响婚姻关系的双方成员 二元地。320名AD配偶照顾者将完成依恋、生活质量、 照顾者负担，悲伤症状，并参与抽血以评估炎症和GCR，以及HF- 心率变异性在两年的时间里有四次。他们还将参加关于广告的简短采访 配偶的生活质量和依恋取向。轻度至中度AD患者也将回答问题 以前在AD患者中用于评估依恋和QOL。 本研究的目的是描述阿尔茨海默病配偶照顾者的 关联污名化的经历，指的是公众对自己的负面看法的国际化， 焦虑和抑郁以及副交感神经活动，如心率变异性所指示的。以前的研究 表明，照顾者受到经历耻辱，有助于慢性压力，因此， 自主神经失调，这是心血管疾病的预测。然而，据我们所知，没有研究表明， 考虑附属污名的不利影响如何影响AD配偶之间的副交感神经活动 照顾者我们预计，AD配偶照顾者谁经历较高的附属耻辱将与 焦虑和抑郁水平升高，心率变异性水平降低。我们必须设法了解这些 互动更好，所以我们可以确定哪些AD配偶照顾者最倾向于不利的健康 的影响，并提供有针对性的治疗，以减轻紧张的压力，AD的治疗。

ABSTRACT The goal of the parent project is to understand which AD spousal caregivers are most vulnerable to the deleterious physical health effects of spousal dementia caregiving as they navigate the experience of living bereavement, while coping with the burden of caregiving and trying to maintain QOL. As an exploratory aim, we will examine how these individual in attachment orientation affect both members of the marital relationship dyadically. Three hundred and twenty AD spousal caregivers will complete assessments of attachment, QOL, caregiver burden, grief symptoms, and participate in a blood draw to evaluate inflammation and GCR, and HF- HRV four times over a two-year period. They will also participate in a brief interview in reference to the AD spouse's QOL and attachment orientation. The AD patient with mild to moderate AD will also answer questions used previously among AD patients to assess attachment and QOL. The present study aims to characterize the association between Alzheimer's Disease spousal caregivers' experience of affiliate stigma, which refers to the internationalization of negative public views toward oneself, anxiety and depression and parasympathetic activity, as indexed by heart rate variability. Previous research suggests that caregivers are subject to experiencing stigma that contributes to chronic stress, and consequently, autonomic imbalance, which is predictive of cardiovascular disease. Yet, to our knowledge, no study exists that considers how the adverse effects of affiliate stigma influence parasympathetic activity among AD spousal caregivers. We anticipate that AD spousal caregivers who experience higher affiliate stigma will associate with increased levels of anxiety and depression and decreased levels of HRV. We must seek to understand these interactions better, so we may determine which AD spousal caregivers are most disposed to the adverse health effects of affiliate stigma and provide targeted treatments to alleviate the intense stress of AD caregiving.