Quantifying the Influence of Yogic Breathwork on Cerebrospinal Fluid Circulation

量化瑜伽呼吸对脑脊液循环的影响

• 批准号: 10293296
• 负责人: Selda Yildiz
• 金额: $ 10.94万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293296
• 关键词: Abdomen; Address; Alzheimer' s Disease; Blood Circulation; Blood Pressure; Blood Vessels; Brain; Breathing; Cardiac; Central Nervous System Diseases; Cerebrospinal Fluid; Conscious; Ensure; Equipment; Frequencies; Goals; Health; Health Benefit; Heart Rate; Human; Imaging Techniques; Intercellular Fluid; Intervention; Investigation; Learning; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Meditation; Metabolic; Methodology; Microcirculation; Mind-Body Intervention; Multiple Sclerosis; Nervous System Physiology; Neuraxis; Neurologic; Outcome; Participant; Pattern; Periodicity; Phase; Physiologic pulse; Physiology; Play; Polysomnography; Posture; Relaxation; Respiration; Risk; Rodent; Role; Sleep; Sleep Wake Cycle; Slow-Wave Sleep; Time; United States; Wakefulness; Well in self; Yoga; cerebrospinal fluid flow; cost; experience; glymphatic function; glymphatic system; heart rate variability; imaging approach; improved; improvement on sleep; in vivo evaluation; intervention effect; multimodality; non-invasive imaging; novel; novel strategies; perivascular channels; post intervention; research study; respiratory; sleep pattern; sleep quality; solute; wasting

Modified Project Summary/Abstract Section Yogic breathwork is a low-risk low-cost mind-body therapy that can be easily learned and performed without any additional equipment. The practices of yogic breathwork have been demonstrated to be effective for a wide range of health conditions including sleep and neurological conditions. While underlying mechanisms are still not fully known, one previously studied mechanism for the health benefits of yogic breathwork is through parasympathetic activation as evidenced by decreased respiration rate, heart rate and blood pressure, and increased heart rate variability. Another mechanism for explaining the health benefits of yogic breathwork can be its direct influence on cerebrospinal fluid (CSF) circulation, which to date has not been investigated due to lack of non-invasive methodology. CSF circulates by bulk flow (macrocirculation) around the central nervous system (CNS) while ensuring the health of the CNS. CSF undergoes periodic pulsations due to arterial pulsation and respiration. While cardiac-driven CSF has been studied extensively, respiratory-driven CSF is not very well-understood due to lack of real-time non-invasive approaches. To address this gap, we have recently developed a real-time phase-contrast magnetic resonance imaging (RT-PCMRI) technique, and demonstrated that deep slow abdominal breathing - compared to natural breathing - increases the amplitude of the CSF flow velocities while lowering the frequency of respiratory-driven CSF flow, suggesting that breathing patterns have quasi-immediate influence on the modulation of CSF circulation. Additionally, CSF circulation plays a central role in maintaining glymphatic function (microcirculation), which is a recently identified brain-wide cleaning mechanism that supports the rapid interchange of CSF and interstitial fluid (ISF), and facilitates the clearance of solutes and metabolic wastes from the brain interstitium, preferentially during sleep compared to wakefulness. In order to evaluate glymphatic function in human brain, we have recently developed a novel non-invasive imaging approach incorporating simultaneous polysomnography and magnetic resonance spectroscopy measurements across sleep-wakes cycles, which indicated enhanced glymphatic activity during sleep, particularly in slow wave sleep. Because we know that the entry of CSF along perivascular channels facilitates glymphatic function in rodents, we hypothesize that the influence of yogic breathwork on CSF flow dynamics will also facilitate the glymphatic activity. Because we know yoga improves sleep, and glymphatic function is mainly active during sleep compared to the wakefulness, we expect that a regular practice of yogic breathwork will improve sleep quality, and will benefit the glymphatic activity. Thus, we propose to: (1) determine the influence of an 8-week yogic breathwork intervention on CSF flow dynamics; (2) determine the influence of an 8-week yogic breathwork intervention on CSF circulation (flow dynamics and glymphatic function), and; (3) measure the effects of the breathwork intervention on participants’ long-term sleep patterns, and correlate the degree of sleep improvement with the changes in CSF circulation measured in Aim 2.

修改的项目摘要/摘要部分 瑜伽呼吸是一种低风险的低成本思维体疗法，可以轻松学习和执行，而无需任何其他设备。瑜伽呼吸的实践已被证明对包括睡眠和神经系统疾病在内的多种健康状况有效。虽然基本机制仍然尚不清楚，但先前研究的瑜伽呼吸益处的机制是通过副交感神经激活，这是通过呼吸率，心率和血压增加以及心率变异性提高所证明的。解释瑜伽呼吸的健康益处的另一种机制可能是其对脑脊液（CSF）循环的直接影响，迄今为止，由于缺乏非侵入性方法，迄今为止尚未对此进行研究。 CSF圆圈通过围绕中枢神经系统（CNS）的散装流量（大循环）确保了中枢神经系统的健康状况。 CSF由于动脉搏动和呼吸而经历周期性的脉动。尽管对心脏驱动的CSF进行了广泛的研究，但由于缺乏实时的非侵入性方法，呼吸驱动的CSF并不是很好的理解。 To address this gap, we have recently developed a real-time phase-contrast magnetic resonance imaging (RT-PCMRI) technique, and demonstrated that deep slow abdominal breathing - compared to natural breathing - increases the amplifier of the CSF flow velocities while lowering The frequency of respiratory-driven CSF flow, suggesting that breathing patterns have quasi-immediate influence on the modulation of CSF circulation.此外，CSF循环在维持糖性功能（微循环）方面起着核心作用，这是一种最近确定的大脑清洁机制，可支持CSF和间质液（ISF）的快速互换，并促进了在大脑质量性质上与Sleeptenty of Speeptys相比，可溶质和代谢性废物的清除率，并促进了清除的清除。为了评估人脑中的糖染色功能，我们最近开发了一种新型的非侵入性成像方法，该方法融合了跨睡眠效果周期的同时多聚际仪和磁共振光谱测量，这表明在睡眠期间，尤其是在慢波睡眠中，糖染色增强。因为我们知道CSF沿着血管周通道的进入促进了啮齿动物的糖瘤功能，所以我们假设瑜伽呼吸对CSF流动动力学的影响也将促进糖化活性。因为我们知道瑜伽可以改善睡眠，并且与清醒相比，在睡眠期间，子糖性功能主要是活跃的，所以我们预计常规的瑜伽呼吸练习将改善睡眠质量，并有益于糖果活动。这就是我们建议：（1）确定为期8周的瑜伽呼吸干预对CSF流动动力学的影响； （2）确定为期8周的瑜伽呼吸干预对CSF循环（流动动力学和糖基函数）的影响，并且； （3）测量呼吸干预对参与者长期睡眠模式的影响，并将睡眠改善程度与AIM 2中测得的CSF循环的变化相关。