Engagement Optimization Unit

摘要：接合优化单元(EOU) 随着分子基因组学的进步，我们对肿瘤进化的驱动因素有了更好的理解 治疗反应，但将西班牙裔/拉丁裔结直肠癌患者纳入这些研究的情况很少。此外， 几乎没有经验数据来指导教育、同意、招生和保留的最佳实践 H/L患者在癌症基因组学研究中，也没有文化，语言，识字和算术 适当的工具，用于接触这些患者或促进他们收到的数据的解释。更好的 理解H/L如何理解、重视和交流基因组相关信息是至关重要的 为严格的研究奠定基础，以优化患者的参与度和结果。交战优化 单位(EOU)将通过进行严格的研究来填补这些空白，以产生基于证据的最佳做法和 通过验证特定于文化的工具来优化拉美裔/拉丁裔患者的参与度和赋权。这 将通过试验、评估、实施和重新评估的迭代过程来完成 在一项在LAC+USC和Norris对275名患有转移性结直肠癌的H/L参与者以及单独的 500名H/L结直肠癌患者(包括新诊断的和存活的)将从事基因组学研究 测序和随访。具体目标是：(1)评估儿童的教育和沟通需求 H/L结直肠癌患者参与肿瘤基因组学研究的相关情况；并评估语言的作用 适应文化、计算能力和健康素养；(2)为H/L结直肠癌患者的参与制定最佳做法 在基因组特征的知情同意中；(3)确定最有效的策略来 将基因组结果传达给H/L结直肠癌患者；以及(4)开发和测试综合工具包( 通过叙事赋权工具包参与拉美裔/拉丁裔基因组(H/L G.E.N.E.)供以下人员使用 促进(社区卫生工作者)和其他提供者，目的是优化H/L 参与、提高招募和加强H/L患者对癌症基因组研究的留存。

ABSTRACT: ENGAGEMENT OPTIMIZATION UNIT (EOU) With advances in molecular genomics, we have an improved understanding of the drivers of tumor evolution and therapy response, yet inclusion of Hispanic/Latino CRC patients in these studies has been minimal. Moreover, there are virtually no empirical data to inform best practices for educating, consenting, enrolling and retaining H/L patients in cancer genomics investigations, nor are there culturally, language, literacy and numeracy appropriate tools to utilize to reach these patients or to facilitate interpretation of data they receive. A better understanding of how H/Ls understand, value and communicate genomics-related information is the essential foundation for rigorous research to optimize patient engagement and outcomes. The Engagement Optimization Unit (EOU) will fill these gaps by conducting rigorous research to generate evidence-based best practices and by validating culturally specific tools for optimizing Hispanic/Latino patient engagement and empowerment. This will be accomplished via an iterative process of experimentation, evaluation, implementation and re-evaluation in a study population at LAC+USC and Norris of 275 H/L participants with metastatic CRC, as well as a separate cohort of 500 H/L participants with CRC (both newly diagnosed and survivors) who will be engaged in genomic sequencing and follow up. The Specific Aims are: (1) to assess the educational and communication needs of H/L CRC patients related to participation in cancer genomics research; and evaluate the role of language, acculturation, numeracy and health literacy; (2) to develop best practices for engagement of H/L CRC patients in informed consent for genomic characterization; (3) to determine the most efficacious strategies to communicate genomic results to H/L CRC patients; and (4) to develop and test a comprehensive tool kit (The Hispanic/Latino Genomic Engagement through Narrative Empowerment Tool Kit (H/L G.E.N.E.)) for use by promotores de salud (community health workers) and other providers with the purpose of optimizing H/L engagement, enhancing recruitment and strengthening retention of H/L patients into cancer genomics research.