The Chorotega CKDu Epidemiology Field Study

Chorotega CKDu 流行病学实地研究

• 批准号: 10300149
• 负责人: Mariela Arias-Hidalgo
• 金额: $ 53.48万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-25 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10300149
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Affect; Age Distribution; Agricultural Workers; Agriculture; Biological; Biological Markers; Case-Control Studies; Cessation of life; Chemical Exposure; Chemicals; Child; Chronic Kidney Failure; Clinical; Clinical assessments; Collaborations; Communities; Community Health; Community Physician; Costa Rica; County; Data; Data Coordinating Center; Dietary Factors; Disease; Enrollment; Environmental Exposure; Environmental Health; Environmental and Occupational Exposure; Epidemic; Epidemiology; Ethical Issues; Etiology; Exposure to; Family; Family Study; Foundations; Frequencies; Funding; Future; Genetic Predisposition to Disease; Glomerular Filtration Rate; Goals; Government Officials; Health; Health Personnel; Healthcare; Heat Stress Disorders; Human; Individual; Injury to Kidney; Intervention; Kidney; Knowledge; Language; Liberia; Life Style; Measurement; Measures; Metals; Methods; Natural History; Non-Steroidal Anti-Inflammatory Agents; North Carolina; Occupational; Occupational Exposure; Occupational Health; Participant; Patient Self-Report; Pesticides; Pharmaceutical Preparations; Phenotype; Policies; Prevalence; Prevention; Prospective Studies; Province; Public Health; Research; Research Design; Research Personnel; Resources; Risk Assessment; Risk Factors; Sampling; Science; Seasons; Serum; Sex Distribution; Silicones; Site; Solid; Time; Universities; Urine; Vulnerable Populations; Woman; Work; Workplace; agricultural community; base; case control; combustion product; community based participatory research; dietary; drinking water; epidemiology study; field study; kidney biopsy; male; predictive marker; premature; prospective; recruit; response; safety and feasibility; social; urinary

ABSTRACT Chronic kidney disease of uncertain etiology (CKDu) has reached epidemic proportions in Costa Rica’s Guanacaste province (Chorotega region), where it has become a leading cause of premature death. CKDu has a high burden among young, male agricultural workers, but women and children are also affected, and its causes remain largely unknown. In response to the RFA for Field Epidemiology Sites for the Chronic Kidney Diseases of UnceRtain Etiology in Agricultural Communities Research Consortium (CURE Consortium), we propose to recruit, enroll and follow 400 participants with evidence of CKDu and 400 control participants for comprehensive assessments of individual risk factors and contextual exposures for CKDu. We propose an Epidemiology Field Center in Liberia, Chorotega region, as part of a collaboration among the University of North Carolina at Chapel Hill, the University of Costa Rica and local nephrologists in the Chorotega region. Our study design includes a large case-control study with nested substudies and state-of-the art exposure assessment methods to identify risk factors and cause(s) of CKDu. We will conduct clinical assessments and collect extensive biological and environmental/occupational samples and data. In addition to analysis of a wide range of self-reported lifestyle/demographic, environmental, and occupational factors and environmental measurements in the case-control study, we will conduct 1) a nested family study to assess familial aggregation/genetic susceptibility; 2) a prospective study among controls of serial targeted and non-targeted contemporary environmental/occupational chemical exposures (exposomics) measured in urine and drinking water in relation to measures of acute kidney injury (AKI) and new-onset CKDu; and 3) a prospective field study among a representative sample of controls employed in agriculture and construction to investigate seasonal workplace exposures through repeat measures of targeted and non-targeted chemical exposures (exposomics, including but not limited to pesticide, metals, and combustion products), assessed in urine and via silicone wristband samplers, in relation to measures of heat stress-related AKI. We propose to assemble a resource of sufficient breadth, depth and size to permit informative assessments of a wide range of risk factors, including environmental/occupational exposures and health contexts, with sufficient power to identify one or more causes of CKDu that could be targeted for prevention, intervention or policy.

摘要