Robotically Augmented Mental Practice for Neuromotor Facilitation

用于神经运动促进的机器人增强心理练习

• 批准号: 10301588
• 负责人: MINORU SHINOHARA
• 金额: $ 40.75万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10301588
• 关键词: Adopted; Adult; Affect; Appearance; Auditory; Biomedical Engineering; Classification; Clinical; Cognitive; Complex; Development; Digit structure; Disabled Persons; Distal; Electromyography; Engineering; Esthesia; Extensor; Feasibility Studies; Film; Fingers; Hand; Hand functions; Healthcare; Hearing; Image; Imagery; Impairment; Individual; Institutes; Intervention; Joints; Lead; Measures; Mechanics; Motor; Motor Cortex; Movement; Muscle; Muscle function; Nervous System Trauma; Neurosciences; Outcome; Performance; Population; Procedures; Prosthesis; Psyche structure; Randomized Controlled Trials; Reaction Time; Rehabilitation therapy; Research Institute; Robotics; Shoulder; Spinal cord injury; Stroke; Surface; System; Technology; Testing; Thinness; Training; Transcranial magnetic stimulation; Upper Extremity; User-Computer Interface; Visual; Wireless Technology; arm; base; deep learning; deep learning algorithm; disability; effective intervention; efficacy evaluation; evidence base; experience; functional improvement; grasp; hand dysfunction; hemiparetic stroke; improved; innovation; long-term rehabilitation; mental practice; motor recovery; motor rehabilitation; neuromuscular; neurophysiology; physical therapist; post stroke; rehabilitation strategy; robot control; sound; stroke rehabilitation; stroke survivor; trend; virtual; visual motor

SUMMARY Upper limb motor function is often impaired due to neurologic injuries such as stroke and spinal cord injury. The ultimate objective is to innovate effective motor rehabilitation for enhancing clinical outcomes in stroke populations by discovering and applying scientific mechanisms and developing new engineering technologies to facilitate neuromotor adaptation. In stroke rehabilitation, mental practice, such as motor imagery and action observation, is a very effective intervention when performed appropriately. The challenge is that performance quality and efficacy of mental practice are highly variable and can be compromised. It is hypothesized that control and observation of robotic grasp and release actions via synergistic proximal muscle activation will increase neuromotor excitability of the non-activated distal muscles and hand function due to cognitive engagement with the externally present and visible robotic prosthesis. The Specific Aim of this proof of concept and feasibility study is to develop and test robotically augmented mental practice with synergistic proximal muscles for neuromotor facilitation of hand muscles. A robotically augmented mental practice will be developed for individuals to grasp and release an object by controlling the associated actions of a sound- generating robotic prosthesis utilizing surface electromyography (EMG) of shoulder/trunk muscles with deep learning algorithms. To demonstrate the proof of concept of increased neuromotor excitability and hand performance in able-bodied adults, transcranial magnetic stimulation will be applied to the motor cortex for the non-activated hand muscles and reaction time and maximal voluntary contraction performances will be tested with a finger in various practice conditions. The feasibility and possible trends in stroke survivors with upper extremity disabilities will also be examined. The project will be performed at the Georgia Institute of Technology by an interdisciplinary team of experts in fields directly related to the study: an applied physiologist, mechanical and biomedical engineers, a physical therapist, and a clinical neuroscientist. The successful completion of the study will provide augmented mental practice for neuromotor facilitation for distal muscles, and evidence for efficacy will be provided in able-bodied adults and feasibility in post-stroke individuals. The results will lead to the development of a more effective priming intervention before physical practice that can facilitate functional improvement as part of stroke rehabilitation.

总结 上肢运动功能通常由于神经损伤如中风和脊髓损伤而受损。 最终目标是创新有效的运动康复，以提高中风的临床疗效 通过发现和应用科学机制和开发新的工程技术， 以促进神经运动适应。在中风康复中，心理练习，如运动想象和动作， 观察，是一个非常有效的干预时，适当执行。挑战在于， 心理练习的质量和功效是高度可变的，并且可以被折衷。它是假设 通过协同近端肌肉激活来控制和观察机器人抓取和释放动作， 增加非激活的远端肌肉的神经运动兴奋性和由于认知的手功能 与外部存在且可见的机器人假体接合。这个证明的具体目的 概念和可行性研究是开发和测试机器人增强的心理实践与协同 近端肌肉用于手部肌肉的神经运动促进。一个机器人增强的心理练习将是 为个人开发，通过控制声音的相关动作来抓住和释放物体， 利用肩部/躯干肌肉的表面肌电图（EMG）产生机器人假体， 学习算法为了证明增加神经运动兴奋性和手的概念证据， 在健全的成年人的表现，经颅磁刺激将被应用于运动皮层， 将测试非激活手部肌肉和反应时间以及最大随意收缩性能 在各种不同的实践条件下。脑卒中幸存者中应用高血压的可行性和可能趋势 肢体残疾也将被检查。该项目将在格鲁吉亚研究所进行， 技术由与研究直接相关领域的跨学科专家团队提供：应用生理学家， 机械和生物医学工程师，物理治疗师和临床神经科学家。成功 研究的完成将为远端肌肉的神经运动促进提供增强的心理练习， 将提供在健全成人中的疗效证据和在卒中后个体中的可行性证据。的 结果将导致开发一种更有效的启动干预之前，物理练习， 作为中风康复的一部分，促进功能改善。