2/2: Feasibility study to build a collaboration in genetics and genomic cancer research

2/2：建立遗传学和基因组癌症研究合作的可行性研究

• 批准号: 10302815
• 负责人: Neelam Azad
• 金额: $ 21.52万
• 依托单位: HAMPTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10302815
• 关键词: Address; African American; Area; Behavioral; Biological; Biometry; Clinical Investigator; Collaborations; Complement; Consultations; Coupled; Data; Data Collection; Detection; Educational Activities; Educational Materials; Educational process of instructing; Ensure; Environment; Environmental Risk Factor; Epidemiology; Etiology; Exposure to; Extramural Activities; Faculty; Feasibility Studies; Funding; Genetic; Genetic Variation; Genomics; Goals; Health; Institutes; Institution; Interdisciplinary Study; Joints; Lead; Malignant Neoplasms; Malignant neoplasm of prostate; Mentors; Methodology; Methods; Modeling; Outcome; Pilot Projects; Population; Productivity; Records; Registries; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Series; Site; Students; Time; Training; Training Activity; Training and Education; Translational Research; Travel; Treatment outcome; Universities; Vision; Vulnerable Populations; anticancer research; cancer epidemiology; cancer genetics; cancer genomics; cancer health disparity; cancer type; didactic education; education research; epidemiology study; experience; faculty research; genetic epidemiology; genomic epidemiology; hands on research; health disparity; improved; innovation; malignant breast neoplasm; medical schools; minority disparity; novel; programs; proton therapy; response; social factors; statistics; success; survivorship; therapy outcome; undergraduate student

Project Summary This is a partnership between Hampton University (HU) and the Tisch Cancer Institute (TCI) at Mount Sinai School of Medicine that seeks to establish robust collaborations on-site and online training and education to increase HU faculty’s research capacity in the area of genetics and genomics and health disparities, while increasing TCI research in health disparities, using the examples of prostate and breast cancer. The final goal is to create a competitive and sustainable joint Center for Genetics and Genomics Cancer Research, encompassing the genetics and genomics aspects of health disparities to explain population differences in breast and prostate cancer occurrence and outcome. The proposal is grounded in a longstanding and productive undergraduate educational collaboration between faculty at these two institutions, but is distinct in its focus, methods, and goals. Hence, the proposed program will utilize the best practices learned from previous collaborative endeavors to inform and create an innovative platform which will enhance research capacity at both institutions while addressing key institutional challenges. Our goals will be accomplished through a series of well-coordinated training/educational activities and two pilot research projects that were strategically chosen to meet our overarching goals of 1) improving health outcomes in vulnerable populations, 2) addressing gaps in cancer disparities research, 3) augmenting genomic, statistics, epidemiology expertise and 4) enhancing investigator productivity and extramural funding competitiveness. Training and education will aim to increase HU faculty’s research capacity in the area of genetics and genomics and health disparities, using the examples of prostate and breast cancer. It will provide TCI ISMMS with access and collaboration to scientific projects in breast and prostate cancer disparity etiology, treatment and outcome, as well as to a mechanism to increase the diversity of the genetics and genomics faculty, which has traditionally lacked diversity. To ensure the success of the training and education program, we have assembled an excellent team of faculty with outstanding mentoring and teaching track records, along with extensive expertise in developing and implementing new initiatives aimed at diversifying the clinical investigator workforce and eliminating health disparities. HU faculty will also be exposed to the most novel and cutting edge methods in cancer genomics through the completion of the pilot research project.

项目摘要 这是汉普顿大学（HU）和Tisch癌症研究所（TCI）之间的合作， 西奈山医学院寻求建立强有力的现场和在线合作 培训和教育，以提高胡教师在遗传学领域的研究能力， 基因组学和健康差异，同时增加TCI研究健康差异，使用 前列腺癌和乳腺癌的例子。最终目标是创造一个有竞争力和可持续的 联合中心遗传学和基因组学癌症研究，包括遗传学和 健康差异的基因组学方面解释乳腺和前列腺的人口差异 癌症的发生和结果。该提案基于一项长期而富有成效的 这两个机构的教师之间的本科教育合作，但不同的是， 它的重点，方法和目标。因此，拟议的方案将利用最佳做法 从以前的合作努力中吸取了教训，以告知和创建一个创新的平台， 将加强这两个机构的研究能力，同时应对关键的体制挑战。 我们的目标将通过一系列协调良好的培训/教育活动来实现 和两个试点研究项目，这是战略选择，以满足我们的总体目标1） 改善弱势群体的健康结果，2）解决癌症差异方面的差距 研究，3）增强基因组学，统计学，流行病学专业知识和4）提高 研究人员的生产力和校外资金的竞争力。培训和教育的目的是 提高HU教师在遗传学和基因组学与健康领域的研究能力 差异，使用前列腺癌和乳腺癌的例子。它将为TCI ISMMS提供 在乳腺癌和前列腺癌差异病因学方面的科学项目的访问和合作， 治疗和结果，以及增加遗传多样性的机制， 基因组学系，传统上缺乏多样性。为了确保培训的成功 和教育计划，我们已经聚集了一个优秀的教师团队， 辅导和教学的跟踪记录，沿着在开发和 实施旨在使临床研究人员队伍多样化的新举措， 消除健康差距。胡教师也将接触到最新颖和最前沿的 通过试点研究项目的完成，癌症基因组学的方法。