Neurodevelopment

项目概要/摘要-项目4。神经发育 本项目的目标是为Berghia脑项目的总体目标提供一个发展视角 理解躯体感觉、嗅觉和视觉处理的实现。这些目标将得到以下方面的帮助： 研究神经元的起源。对已识别神经元的发育起源的研究 基本上在四十年前就停止了，这个项目填补了我们知识的空白。项目4将确定 在中枢和周围神经系统中产生神经元的胚胎细胞。它会识别出 使这些细胞变得独特，并利用这些信息来识别驱动这些细胞所需的调节信息。 荧光融合蛋白在特定的神经元。这些见解将扩展我们对神经发生的理解 到软体动物，一种多样的生物体，相对而言研究不足，因此具有潜在的 揭示神经系统发育的新细胞和分子机制。

PROJECT SUMMARY / ABSTRACT – Project 4. Neurodevelopment The goal of this Project is to provide a developmental perspective to the overall goals of the Berghia Brain Project to understand the implementation of somatotopic, olfactory, and visual processing. These goals will be aided by investigation into the origin of the neurons involved. Work on the developmental origin of identified neurons essentially stopped forty years ago and this project fills that gap in our knowledge. Project 4 will identify the embryonic cells that give rise to neurons in the central and peripheral nervous systems. It will identify the genes that make these cells unique, and use that information to identify the regulatory information necessary to drive fluorescent fusion proteins in specific neurons. These insights will expand our understanding of neurogenesis to molluscs, a diverse clad of organisms that has been relatively understudied, and thus holds potential for uncovering novel cellular and molecular mechanisms for nervous system development.