Neurodevelopment

神经发育

基本信息

批准号：
10302206
负责人：
Deirdre C Lyons
金额：
$ 15.58万
依托单位：
UNIVERSITY OF MASSACHUSETTS AMHERST
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10302206
关键词：
ATAC-seq Address Adolescent Adult Animal Model Animals Anterior Apical Atlases Automobile Driving Biological Assay Biological Metamorphosis Brain Caenorhabditis elegans Calcium Cell Lineage Cells Chimeric Proteins Chromatin Cnidaria Collaborations Crustacea DNA Data Data Science Core Data Set Databases Development Drosophila genus Ectoderm Embryo Embryonic Development Esophagus Gene Expression Gene Transfer Techniques Genes Genetic Genome Genomics Germ Lines Goals Head Heart Intestines Investigation Knowledge Larva Left Maps Methods Modeling Molecular Mus Muscle Nervous system structure Neuraxis Neurons Neurosciences Nucleic Acid Regulatory Sequences Nucleic Acids Organ Organism Outcome Peripheral Nerves Peripheral Nervous System Preparation Process Regulator Genes Regulatory Element Reporter Resolution Series Structure Transcriptional Regulation Transgenes Transgenic Animals Transgenic Organisms Transposase Urochordata Work Zebrafish base blastomere structure cell type experimental study foot genome-wide insight molecular modeling nervous system development network models neurodevelopment neurogenesis novel programs relating to nervous system sensor single-cell RNA sequencing tool transcriptome sequencing transgene expression visual processing

项目摘要

PROJECT SUMMARY / ABSTRACT – Project 4. Neurodevelopment The goal of this Project is to provide a developmental perspective to the overall goals of the Berghia Brain Project to understand the implementation of somatotopic, olfactory, and visual processing. These goals will be aided by investigation into the origin of the neurons involved. Work on the developmental origin of identified neurons essentially stopped forty years ago and this project fills that gap in our knowledge. Project 4 will identify the embryonic cells that give rise to neurons in the central and peripheral nervous systems. It will identify the genes that make these cells unique, and use that information to identify the regulatory information necessary to drive fluorescent fusion proteins in specific neurons. These insights will expand our understanding of neurogenesis to molluscs, a diverse clad of organisms that has been relatively understudied, and thus holds potential for uncovering novel cellular and molecular mechanisms for nervous system development.

项目摘要 /摘要 - 项目4。神经发育该项目的目的是为伯吉亚脑项目的整体目标提供发展视角了解体体，嗅觉和视觉处理的实现。这些目标将由研究涉及的神经元的起源。研究已确定神经元的发展起源本质上是四十年前停止的，这个项目填补了我们的知识。项目4将确定在中央和周围神经系统中产生神经元的胚胎细胞。它将识别基因这使这些单元单元独特，并使用该信息来识别驾驶所需的监管信息特定神经元中的荧光融合蛋白。这些见解将扩大我们对神经发生的理解对于软体动物来说，多种有机体相对理解，因此具有揭示了用于神经系统发育的新型细胞和分子机制。