Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS)

培训非洲人领导和执行神经学试验

• 批准号: 10302951
• 负责人: BRUCE OVBIAGELE
• 金额: $ 24.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10302951
• 关键词: Africa; African; Clinical; Clinical Research; Event; Evidence based treatment; Exposure to; Face; Faculty; Foundations; Generations; Goals; Grant; Individual; Intervention; Knowledge; Lead; Leadership; Master' s Degree; Medicine; Mentors; Morbidity - disease rate; Motivation; Neurologic; Neurosciences Research; Nigeria; Pharmaceutical Preparations; Pharmacotherapy; Population; Program Effectiveness; Race; Research; Research Personnel; Risk Factors; Role; Safety; Scientist; Training; Training and Education; Universities; Ursidae Family; career; certificate program; effectiveness evaluation; efficacy testing; ethnic diversity; member; mortality; multidisciplinary; nervous system disorder; precision medicine; programs; skills; symposium; targeted treatment

PROJECT SUMMARY / ABSTRACT Africa faces a growing burden of non-communicable diseases as the fastest growing cause of morbidity and mortality, many of which are neurological disorders. Clinical studies are the foundation advancements in medicine allowing scientists to test the efficacy and safety of a drug, therapy or strategy; and clinical neuroscience research holds great promise to help mitigate the toll of neurological disease. However, the studies that lead to discovery of causal /risk factors & drugs/interventions rarely emanate from African populations, which bear a major brunt of neurological diseases. With the rise of precision medicine utilizing tailored interventions, lack of race-ethnic diversity in generating evidence-based treatments can be a challenge if people of African ancestry are to truly benefit from these targeted therapies. One way to bolster the limited pool of researchers in Africa conducting neurological research and trials is to expose select individuals to coordinated education, training, mentoring, & networking opportunities, thereby raising their odds of becoming successful clinical researchers, thus creating a cadre of people on the continent making academic contributions to the overall field of neurological diseases, including those conditions endemic to Africa. The goal of the Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS) program, is to build sustainable neurological research capacity in Africa through partnerships between US and African organizations. Six scholars will be accepted into the program each year and exposed to educational, mentoring, & networking activities. TALENTS Specific Aims are: 1) To select & retain 24 promising multidisciplinary scholars from a cross-national pool) committed to careers in neurological research; 2) To increase scholars' scientific knowledge, professional skills, motivation, & credentials, in neurological research (Certificate Program, Master’s degree in Clinical Research, Think Tank Sessions, and Scientific Conference events); 3) To enhance mentoring benefits and networking opportunities for Scholars (congruent one-on-one mentoring approach and online networking activities); 4) By end of the grant period to create an independent Master’s degree in Neurological Research at the University of Ibadan in Nigeria, with several member of the faculty being recent TALENTS trainees; 5) To evaluate the effectiveness of the Program. We anticipate that TALENTS will establish a sustainable network of individuals with expertise in neurological research poised to assume leadership and academic faculty roles in Africa, and able to mentor successive generations of locally well-trained and successful neurological researchers in the region.

项目总结/摘要 非洲面临着日益沉重的非传染性疾病负担，这是发病率增长最快的原因 和死亡率，其中许多是神经系统疾病。临床研究是基础的进步， 医学允许科学家测试药物、治疗或策略的功效和安全性;和临床 神经科学研究在帮助减轻神经系统疾病造成的损失方面大有希望。然而，研究 导致发现因果/风险因素和药物/干预措施很少来自非洲人口， 承受着神经系统疾病的主要冲击。随着利用量身定制干预措施的精准医疗的兴起， 如果非洲人在制定基于证据的治疗方法时缺乏种族-民族多样性， 真正受益于这些靶向治疗。一种方法来支持有限的研究人员， 非洲进行神经学研究和试验是为了让选定的个人接受协调的教育， 培训，指导和网络机会，从而提高他们成为成功的临床 研究人员，从而在非洲大陆建立了一个对整个领域做出学术贡献的骨干队伍 神经系统疾病，包括非洲特有的疾病。培训非洲人领导的目标 和执行神经学试验和研究（TALENTS）计划，是建立可持续的神经学研究 通过美国和非洲组织之间的伙伴关系，提高非洲的能力。六位学者将被录取 该计划每年，并接触到教育，指导，和网络活动。具体目标 是：1）选择和保留24个有前途的多学科学者从跨国池）致力于职业 2）增加学者的科学知识，专业技能，动机， 证书，神经学研究（证书课程，临床研究硕士学位，智囊团 会议和科学会议活动）; 3）加强指导的好处和建立联系的机会， 奖学金获得者（一对一辅导办法和在线网络活动）; 4）赠款结束时 在尼日利亚的伊巴丹大学建立一个独立的神经学研究硕士学位， 教师中有几名成员是最近的人才培训学员; 5）评估的有效性， 程序.我们预计，人才将建立一个可持续的网络，个人的专业知识， 神经学研究准备在非洲承担领导和学术教师的角色，并能够指导 该地区几代当地训练有素和成功的神经学研究人员。