Validation of a New Stroke Simulation Model for Evaluating Stroke Prevention and Treatment Policies in Type 2 Diabetes Patients

验证用于评估 2 型糖尿病患者中风预防和治疗政策的新中风模拟模型

基本信息

  • 批准号:
    10302406
  • 负责人:
  • 金额:
    $ 42.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-01 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

Stroke is one of the atherosclerotic cardiovascular diseases that are the leading cause of morbidity and mortality for people with type 2 diabetes (T2DM) and are the largest contributor to the direct and indirect costs of T2MD. Despite improvements in the management of type T2MD, the implementation level of these preventive interventions and treatment for T2MD complications is still suboptimal. Substantial opportunity exists to further improve diabetes control to prevent primary stroke and improve early management to reduce stroke related morbidity, mortality, and cost. We will first validate a new stroke microsimulation model for T2DM that reflects the modern paradigm of diabetes progression, stroke management, and treatment. This model will then be used to evaluate the cost-effectiveness of enhanced levels of implementing seven primary prevention strategies and expanding the current acute ischemic stroke treatment guideline to include selected wake-up stroke patients based on perfusion imaging for stroke in T2DM patients from a national perspective. The results of the evaluation will advance scientific knowledge and will have major implications for health policies for stroke prevention and treatments in type 2 diabetes patients.
脑卒中是动脉粥样硬化性心血管疾病之一, 2型糖尿病(T2DM)患者的发病率和死亡率,并且是 T2MD的直接和间接成本。尽管T2MD型的管理有所改进, 这些预防干预措施和T2MD治疗的实施水平 并发症仍然不理想。存在进一步改善糖尿病的巨大机会 控制以预防原发性卒中,改善早期管理以减少卒中相关 发病率、死亡率和成本。我们将首先验证一个新的中风微观模拟模型, T2DM反映了糖尿病进展、卒中管理和 治疗然后,将利用这一模式来评估提高 实施七项一级预防战略,扩大目前急性缺血性心脏病的 卒中治疗指南纳入基于灌注的选定醒后卒中患者 从国家的角度来看,T2DM患者的脑卒中成像。评价结果 将推进科学知识,并将对中风的卫生政策产生重大影响 2型糖尿病患者的饮食习惯

项目成果

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