Validation of a New Stroke Simulation Model for Evaluating Stroke Prevention and Treatment Policies in Type 2 Diabetes Patients

中风是动脉粥样硬化性心血管疾病之一，是导致中风的主要原因 2型糖尿病(T2 DM)患者的发病率和死亡率是 T2MD的直接和间接成本。尽管改进了T2MD型的管理， T2MD预防干预和治疗的实施水平 并发症仍然是次优的。进一步改善糖尿病的机会很大 控制以预防原发性卒中并改善早期管理以减少与卒中相关的疾病 发病率、死亡率和成本。我们将首先验证一个新的笔划微观模拟模型 T2 DM反映了糖尿病进展、中风管理的现代范式，以及 治疗。然后，这个模型将被用来评估增强水平的 实施七项一级预防策略扩大当前急性脑缺血 卒中治疗指南将包括基于血流灌注的选定唤醒卒中患者 国家视角下T2 DM患者卒中的影像研究。评估的结果 将促进科学知识的发展，并将对中风的卫生政策产生重大影响 2型糖尿病的预防和治疗。

Stroke is one of the atherosclerotic cardiovascular diseases that are the leading cause of morbidity and mortality for people with type 2 diabetes (T2DM) and are the largest contributor to the direct and indirect costs of T2MD. Despite improvements in the management of type T2MD, the implementation level of these preventive interventions and treatment for T2MD complications is still suboptimal. Substantial opportunity exists to further improve diabetes control to prevent primary stroke and improve early management to reduce stroke related morbidity, mortality, and cost. We will first validate a new stroke microsimulation model for T2DM that reflects the modern paradigm of diabetes progression, stroke management, and treatment. This model will then be used to evaluate the cost-effectiveness of enhanced levels of implementing seven primary prevention strategies and expanding the current acute ischemic stroke treatment guideline to include selected wake-up stroke patients based on perfusion imaging for stroke in T2DM patients from a national perspective. The results of the evaluation will advance scientific knowledge and will have major implications for health policies for stroke prevention and treatments in type 2 diabetes patients.