Core A: Administrative and Data Sharing Core

项目总结：管理核心A 行政核心的目标是多方面的。首先，管理核心A将作为 U54 FTD无墙中心的中央组织小组。管理核心将监督和指导 FTD CWOW的所有科学活动，并通过建立 加州大学旧金山分校和华盛顿大学团队之间的月度会议。第二，核心将 向调查员提供行政、财务和组织支助。它将产生报告 并跟踪里程碑和可交付成果。管理核心也将作为一个 中心的内部数据共享和管理中心。这样，它既开发了新的， 利用现有的数据组织伙伴关系。最后，管理核心将生成并维护 面向公众的网络资源和数据库，包括Tau代谢途径数据库（TMDB） Tau多基因风险评分（TPRS）行政核心将由Aimee Kao博士领导 与共同负责人詹妮弗·横山博士如果中心获奖，核心将招募一名科学家， 咨询委员会（SAB），将就该小组的科学和管理方面提出建议。的 SAB将每年召开一次会议，就科学方向向CWOW提供建议。核心将与国家卫生研究院合作 和SAB监督里程碑和可交付成果的实现。最终，这个核心将是 直接负责CWOW的生产力，方向和成功。

PROJECT SUMMARY: Admin Core A The objectives of the Administration Core are multi-fold. First, the Admin Core A will serve as the central organizing group for the U54 FTD Center without Walls. The Admin Core will oversee and direct all scientific activities of the FTD CWOW and promote collaboration and communication by setting up monthly meetings between the UCSF and Washington University teams. Secondly, the Core will provide administrative, financial and organizational support for the investigators. It will produce reports on Center activities and keep track of milestones and deliverable. The Admin Core will also serve as an internal data sharing and management hub for the Center. In this way, it both develop new and leverage existing partnerships for data organization. Finally, the Admin Core will generate and maintain public facing web resources and databases, including the Tau Metabolism Pathway Database (TMDB) and the Tau Polygenic Risk Score (TPRS). The Administrative Core will be headed by Dr. Aimee Kao with Co-Lead Dr. Jennifer Yokoyama. If the Center is awarded, the Core will recruit a Scientific Advisory Board (SAB), that will advise on the scientific and management aspects of the group. The SAB will convene annually to advise the CWOW on scientific direction. The Core will work with the NIH and SAB to supervise the achievement of milestones and deliverables. Ultimately, this Core will be directly responsible for the CWOW’s productivity, direction and success.