Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 10304668
• 负责人: Timothy C. Heeren
• 金额: $ 25.27万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304668
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adverse event; Affect; Alcohol consumption; Alcohols; Behavior Therapy; Behavioral; Biometry; Boston; Cardiovascular Diseases; Clinical Trials; Cognitive; Cohort Analysis; Cohort Studies; Collaborations; Collection; Data; Data Analyses; Data Collection; Drug Use Disorder; Ecological momentary assessment; Elderly; Enrollment; Funding; HIV; HIV Infections; Health; Health behavior; Home; Infection; Interdisciplinary Study; Intervention; Intervention Trial; Investigation; Lead; Life; Life Style; Longevity; Mentors; Motivation; National Institute on Alcohol Abuse and Alcoholism; Osteopenia; Outcome; Pain; Participant; Pharmaceutical Preparations; Physical Function; Physical activity; Play; Population; Public Health; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Risk Management; Role; Statistical Data Interpretation; Testing; United States National Institutes of Health; Work; alcohol and other drug; alcohol misuse; alcohol research; alcohol use disorder; antiretroviral therapy; base; career; chronic pain; cohort; comorbidity; data management; drinking; efficacy testing; exercise intervention; experience; falls; frailty; mHealth; member; mental function; physical inactivity; randomized trial; secondary analysis; telehealth

PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an important role in the risk for and management of HIV-associated comorbidities. Unhealthy alcohol use can exacerbate two prevalent HIV-related co-occurring conditions, chronic pain and physical inactivity, which in conjunction with alcohol use affect physical and mental function and are associated with a variety of HIV-related comorbidities. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of the Boston Alcohol Research Collaboration of HIV/AIDS (ARCH). In Boston ARCH CC two clinical trials will test interventions aimed at unhealthy alcohol use, pain, and physical inactivity, that impact a variety of other HIV- related comorbidities. The ARCH CC BDM Core will work closely with ARCH CC investigators, providing experience, expertise, and resources toward the planning, conduct, and data analysis of the work of Boston ARCH CC. ARCH CC will also continue to make the existing Boston ARCH Cohort available for secondary analyses, with a focus on mentoring and developing young investigators, and the ARCH CC BDM Core will provide support for developing proposals and conducting analyses of the cohort. The first aim of the ARCH CC BDM Core is to provide comprehensive data management and statistical support for the two ARCH CC clinical trials. Both of these trials focus on behavioral telehealth interventions. Research Project Component-Pain tests the efficacy of an integrated telehealth intervention incorporating motivational and cognitive-behavioral management for reducing unhealthy drinking and chronic pain in PLWH. Research Project Component-Physical Activity tests the efficacy of a home-based lifestyle physical activity intervention with mobile-health delivered components to decrease unhealthy drinking and increase physical activity in PLWH. The second aim of ARCH CC BDM is to support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort. The Boston ARCH cohort enrolled PLWH with current or past unhealthy alcohol use, collecting longitudinal data on alcohol and other drug use and disorders, HIV-related treatment and medication use, health-related behaviors, and physical and mental function outcomes.

项目摘要/摘要 有效的抗逆转录病毒疗法提高了艾滋病毒（PLWH）患者的寿命。饮酒， 在PLWH中常见，在与HIV相关的风险和管理中起着重要作用 合并症。不健康的饮酒会加剧两种普遍的HIV相关的同时发生条件， 慢性疼痛和身体不活动，与酒精的使用有关 并与各种与HIV相关的合并症有关。我们提出了波士顿酒精研究 艾滋病毒/艾滋病合作社中心（波士顿Arch CC）作为波士顿的延伸 艾滋病毒/艾滋病的酒精研究合作（ARCH）。在波士顿Arch CC中，两个临床试验将测试 旨在影响不健康的饮酒，疼痛和身体不活动的干预措施，影响了其他各种HIV- 相关合并症。 Arch CC BDM核心将与Arch CC调查人员紧密合作，提供 经验，专业知识和资源，用于对波士顿工作的计划，行为和数据分析 Arch CC。 Arch CC还将继续使现有的波士顿拱门队列可用于次要 分析，重点是心理和发展年轻的研究人员，Arch CC BDM核心将 为制定提案和进行队列分析提供支持。拱门的第一个目标 CC BDM核心是为两个ARCH提供全面的数据管理和统计支持 CC临床试验。这两个试验都集中在行为远程医疗干预措施上。研究项目 组件培训测试综合远程医疗干预措施的效率，编码动机和 认知行为管理，用于减少PLWH中不健康的饮酒和慢性疼痛。研究项目 组件 - 物理活动测试基于家庭生活方式的身体活动干预的效率 移动健康交付的组件可减少不健康的饮酒并增加PLWH的体育锻炼。 CC BDM的第二个目的是支持现有波士顿拱门的辅助分析 队列，并为访问该队列的受训人员和调查人员提供支持和心理。 波士顿拱门队员招募了PLWH，当时使用当前或过去的不健康酒精使用，收集了有关的纵向数据 酒精和其他药物使用和疾病，与HIV相关的治疗和用药，与健康相关的行为， 以及身体和心理功能的结果。