Biostatistics and Data Management Core

项目摘要/摘要 有效的抗逆转录病毒治疗延长了艾滋病毒感染者(PLWH)的寿命。酗酒， 在PLWH中常见，在HIV相关风险和管理中起着重要作用 合并症。不健康的饮酒会加剧两种流行的艾滋病毒相关共生疾病， 慢性疼痛和缺乏体力活动，与饮酒一起影响身体和精神功能 并与各种与艾滋病毒相关的合并症有关。我们建议波士顿酒精研究中心 关于艾滋病毒/艾滋病-共病中心的合作(波士顿ARCH CC)是波士顿的延伸 艾滋病毒/艾滋病酒精研究合作(ARCH)。在波士顿ARCH CC将进行两项临床试验 针对不健康的饮酒、疼痛和缺乏身体活动的干预措施，这些都会影响到其他各种艾滋病毒- 相关的并存。ARCH CC BDM核心将与ARCH CC调查人员密切合作，提供 波士顿工作的规划、实施和数据分析方面的经验、专业知识和资源 拱形CC.ARCH CC还将继续将现有的波士顿ARCH队列用于次要服务 分析，重点是指导和发展年轻调查人员，ARCH CC BDM核心将 为制定建议和对队列进行分析提供支持。拱门的第一个目标 CC BDM的核心是为两个ARCH提供全面的数据管理和统计支持 CC临床试验。这两项试验都侧重于行为远程健康干预。研究项目 成分-疼痛测试综合远程健康干预的效果，结合了激励和 认知行为管理对减少不健康饮酒和慢性疼痛的作用。研究项目 体力活动测试以家庭为基础的生活方式体力活动干预的有效性 移动健康提供了减少不健康饮酒和增加PLWH体力活动的成分。 ARCH CC BDM的第二个目标是支持对现有的波士顿ARCH进行二次分析 并向进入队列的受训人员和调查人员提供支持和指导。这个 波士顿ARCH队列招募了目前或过去使用不健康酒精的PLWH，收集关于 酒精和其他药物的使用和障碍，艾滋病毒相关的治疗和药物使用，与健康有关的行为， 以及身体和精神功能的结果。

PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an important role in the risk for and management of HIV-associated comorbidities. Unhealthy alcohol use can exacerbate two prevalent HIV-related co-occurring conditions, chronic pain and physical inactivity, which in conjunction with alcohol use affect physical and mental function and are associated with a variety of HIV-related comorbidities. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of the Boston Alcohol Research Collaboration of HIV/AIDS (ARCH). In Boston ARCH CC two clinical trials will test interventions aimed at unhealthy alcohol use, pain, and physical inactivity, that impact a variety of other HIV- related comorbidities. The ARCH CC BDM Core will work closely with ARCH CC investigators, providing experience, expertise, and resources toward the planning, conduct, and data analysis of the work of Boston ARCH CC. ARCH CC will also continue to make the existing Boston ARCH Cohort available for secondary analyses, with a focus on mentoring and developing young investigators, and the ARCH CC BDM Core will provide support for developing proposals and conducting analyses of the cohort. The first aim of the ARCH CC BDM Core is to provide comprehensive data management and statistical support for the two ARCH CC clinical trials. Both of these trials focus on behavioral telehealth interventions. Research Project Component-Pain tests the efficacy of an integrated telehealth intervention incorporating motivational and cognitive-behavioral management for reducing unhealthy drinking and chronic pain in PLWH. Research Project Component-Physical Activity tests the efficacy of a home-based lifestyle physical activity intervention with mobile-health delivered components to decrease unhealthy drinking and increase physical activity in PLWH. The second aim of ARCH CC BDM is to support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort. The Boston ARCH cohort enrolled PLWH with current or past unhealthy alcohol use, collecting longitudinal data on alcohol and other drug use and disorders, HIV-related treatment and medication use, health-related behaviors, and physical and mental function outcomes.