Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 10304668
• 负责人: Timothy C. Heeren
• 金额: $ 25.27万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304668
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adverse event; Affect; Alcohol consumption; Alcohols; Behavior Therapy; Behavioral; Biometry; Boston; Cardiovascular Diseases; Clinical Trials; Cognitive; Cohort Analysis; Cohort Studies; Collaborations; Collection; Data; Data Analyses; Data Collection; Drug Use Disorder; Ecological momentary assessment; Elderly; Enrollment; Funding; HIV; HIV Infections; Health; Health behavior; Home; Infection; Interdisciplinary Study; Intervention; Intervention Trial; Investigation; Lead; Life; Life Style; Longevity; Mentors; Motivation; National Institute on Alcohol Abuse and Alcoholism; Osteopenia; Outcome; Pain; Participant; Pharmaceutical Preparations; Physical Function; Physical activity; Play; Population; Public Health; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Risk Management; Role; Statistical Data Interpretation; Testing; United States National Institutes of Health; Work; alcohol and other drug; alcohol misuse; alcohol research; alcohol use disorder; antiretroviral therapy; base; career; chronic pain; cohort; comorbidity; data management; drinking; efficacy testing; exercise intervention; experience; falls; frailty; mHealth; member; mental function; physical inactivity; randomized trial; secondary analysis; telehealth

PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an important role in the risk for and management of HIV-associated comorbidities. Unhealthy alcohol use can exacerbate two prevalent HIV-related co-occurring conditions, chronic pain and physical inactivity, which in conjunction with alcohol use affect physical and mental function and are associated with a variety of HIV-related comorbidities. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of the Boston Alcohol Research Collaboration of HIV/AIDS (ARCH). In Boston ARCH CC two clinical trials will test interventions aimed at unhealthy alcohol use, pain, and physical inactivity, that impact a variety of other HIV- related comorbidities. The ARCH CC BDM Core will work closely with ARCH CC investigators, providing experience, expertise, and resources toward the planning, conduct, and data analysis of the work of Boston ARCH CC. ARCH CC will also continue to make the existing Boston ARCH Cohort available for secondary analyses, with a focus on mentoring and developing young investigators, and the ARCH CC BDM Core will provide support for developing proposals and conducting analyses of the cohort. The first aim of the ARCH CC BDM Core is to provide comprehensive data management and statistical support for the two ARCH CC clinical trials. Both of these trials focus on behavioral telehealth interventions. Research Project Component-Pain tests the efficacy of an integrated telehealth intervention incorporating motivational and cognitive-behavioral management for reducing unhealthy drinking and chronic pain in PLWH. Research Project Component-Physical Activity tests the efficacy of a home-based lifestyle physical activity intervention with mobile-health delivered components to decrease unhealthy drinking and increase physical activity in PLWH. The second aim of ARCH CC BDM is to support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort. The Boston ARCH cohort enrolled PLWH with current or past unhealthy alcohol use, collecting longitudinal data on alcohol and other drug use and disorders, HIV-related treatment and medication use, health-related behaviors, and physical and mental function outcomes.

项目总结/摘要 有效的抗逆转录病毒疗法延长了艾滋病毒感染者的寿命。酗酒， 在艾滋病毒相关性疾病的风险和管理中起着重要作用。 合并症。不健康的饮酒会加剧两种与艾滋病毒相关的常见并发症， 慢性疼痛和身体活动不足，与饮酒一起影响身体和精神功能 并与多种HIV相关的合并症相关。我们建议波士顿酒精研究 艾滋病毒/艾滋病合作-科摩罗中心（波士顿艾滋病中心），作为波士顿 艾滋病毒/艾滋病酒精研究合作组织（Alcohol Research Collaboration of HIV/AIDS）。在波士顿，两项临床试验将测试 针对不健康的酒精使用、疼痛和缺乏身体活动的干预措施，这些干预措施影响了各种其他艾滋病毒， 相关合并症。BDM核心将与BDM调查人员密切合作， 经验，专业知识和资源，用于波士顿工作的规划，实施和数据分析 你好。波士顿社区大学还将继续为现有的波士顿社区大学队列提供中学教育。 分析，重点是指导和培养年轻的研究人员，ARCH CC BDM核心将 为制定提案和开展群组分析提供支持。第一个目标是， CC BDM核心是为两个企业提供全面的数据管理和统计支持， CC临床试验。这两项试验都侧重于行为远程医疗干预。研究项目 疼痛测试综合远程医疗干预的有效性， 认知行为管理减少不健康的饮酒和慢性疼痛的PLWH。研究项目 身体活动测试的有效性，以家庭为基础的生活方式的身体活动干预， 移动健康提供的组件，以减少不健康的饮酒和增加体力活动的艾滋病毒携带者。 BDM的第二个目标是支持现有波士顿模型的二次分析 队列，并为访问队列的学员和调查人员提供支持和指导。的 波士顿队列研究招募了目前或过去使用不健康酒精的PLWH，收集以下纵向数据： 酒精和其他药物使用和紊乱，艾滋病毒相关治疗和药物使用，健康相关行为， 以及身体和精神功能的结果。