Tool development and validation studies for commercialisation of CanCan Diagnostics products

英国、美国和欧盟之间有近2亿只狗，其中30%-50%的狗会在一生中患上癌症。目前这种疾病的诊断和监测是通过昂贵的、侵入性的和耗时的程序，如高级成像或活组织检查。到目前为止，用于微创筛查的选择非常有限，犬只癌症的早期检测和监测。一种精确的微创多种癌症诊断测试的商业化将对以下方面产生巨大影响：*动物福利和动物主人的福祉。*增加兽医的生产力和潜在的预约时间*全面改进兽医/同伴动物遗传学的学术研究。*减少碳足迹--在大多数动物身上，获取血液样本只需5分钟，而先进成像需要2-3小时。我们已经开发出基于无细胞DNA的诊断方法，它可以分析各种犬类癌症中选定的反复突变的基因，并能够进行精确的疾病检测，即使存在少量突变的DNA。这种类型的检测有可能给兽医肿瘤学领域带来革命性的变化。检测将允许以前负担不起目前昂贵的方法的患者获得疾病监测，有可能允许更早的干预和延长生存时间。这是一个高度可扩展的项目，目标是快速增长的国际市场，以及计算机科学、基因数据分析的非常重要的交叉，这可能对犬类和人类癌症的药物开发产生巨大影响。

Between United Kingdom, United States and European Union there is close to 200 million dogs, from which 30-50% will develop cancer in their lifetime. Currently this disease is diagnosed and monitored through costly, invasive and time-consuming procedures such as advanced imaging or biopsy.To date, there is a very limited number of options for minimally invasive screening, early detection and monitoring of cancer in dogs.Commercialization of a precise minimally invasive multi-cancer diagnostic test will have an immense influence on:* Animal welfare and the well-being of the animals' owners.* Increasing veterinarian productivity and potentially appointment scheduling* Overall improvement of academic research in veterinary / companion animal genetics.* Reducing carbon footprint - obtaining blood sample takes c. 5 minutes in the majority of animals compared to 2-3 hours for advanced imaging.We have developed cell-free DNA-based diagnostic approach which analyses selected recurrently mutated genes in various canine cancers and allows precise disease detection, even if small quantities of mutated DNA are present. This type of assay has the potential to revolutionize the field of veterinary oncology.The test will allow access to disease monitoring in patients previously unable to afford the current costly approach, potentially allowing for earlier intervention and prolonged survival. This is a highly scalable project targeting a rapidly growing international market and the very important intersection of computer science, genetic data analysis which can have an immense impact on drug development for both canine and human cancers.