B cell memory in human food allergy
人类食物过敏中的 B 细胞记忆
基本信息
- 批准号:10306255
- 负责人:
- 金额:$ 75.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-09 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAffinityAllergensAllergicAllergic DiseaseAnaphylaxisAntibodiesAntibody ResponseAsthmaAtopic DermatitisB-Cell ActivationB-LymphocytesBasic ScienceBloodCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCharacteristicsChildChildhoodClinical ResearchCytometryDataDevelopmentDiphtheria ToxoidDiseaseEnvironmentEvolutionFoodFood HypersensitivityFood SupplyFood productionGenerationsGoalsHumanHypersensitivityIL4R geneIgEIgG1ImmuneImmunoglobulin Class SwitchingImmunoglobulin GIn VitroIndividualInflammatoryInstitutesLifeMediatingMediator of activation proteinMemoryMemory B-LymphocyteMilkModelingMolecular ProfilingMusPathogenicityPhenotypePlasma CellsPopulationProteinsPublishingResearchResolutionRiskRoleTetanusTranscriptVaccine AntigenViral AntigensViral Vaccinesatopybaseclinical carecomparativedesignexperimental studyfood allergeninflammatory disease of the intestineinfluenzaviruslongitudinal analysisnew therapeutic targetnovel therapeuticspatient populationresponsesingle-cell RNA sequencingtargeted treatmenttooltranscriptomics
项目摘要
Summary
High affinity IgE antibodies are essential mediators of food allergy, a main cause of life-threatening anaphylaxis.
Most food allergies develop in childhood and affect children disproportionally. A long-standing question in the
allergy field is why allergies to some foods spontaneously cure, while others persist. A key to understanding the
evolution of food allergy may reside in the mechanisms that maintain the B cell memory of high affinity IgE
responses. Experimental studies from our group demonstrated that IgE cells exist mostly as plasma cells and
not IgE memory cells, and that high affinity pathogenic IgE antibodies derive from the sequential switching of
affinity matured IgG1 memory B cells. While the origin of human high affinity IgE is not definitely proved, an
increasing body of work supports a precursor role of IgG memory cells in the generation of human pathogenic
IgE plasma cells. We hypothesize that the existence of high affinity food-specific IgG cells and their ability to
undergo class switching to IgE are critical for allergy persistence. Preliminary studies from our group suggest
that atopic individuals harbor B lymphocytes with a distinct profile that increases their response to activation and
differentiation into IgE plasma cells. We postulate that the atopic immune environment marks allergen-specific
IgG memory cells with a ‘pro-allergic’ signature, and that the presence of these pro-allergic memory cells is
necessary for the development and persistence of food allergy. We propose to investigate the existence of pro-
allergic memory B lymphocytes in food allergic children, in children that outgrew their food allergy, in tolerant
never-allergic children, and in children with non-allergic inflammatory disease. We will determine if memory B
cells that recognize food allergens have a specific phenotype that distinguish them from memory B cells that
recognize virus and vaccines antigens in allergic and non-allergic children. We expect that the findings from this
study will provide tools to predict food-allergy risk and persistence, and help to design new therapies for allergic
diseases.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARIA A CUROTTO DE LAFAILLE其他文献
MARIA A CUROTTO DE LAFAILLE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARIA A CUROTTO DE LAFAILLE', 18)}}的其他基金
Cellular and molecular mechanisms of IgE cell memory in allergic responses
过敏反应中IgE细胞记忆的细胞和分子机制
- 批准号:
9891945 - 财政年份:2017
- 资助金额:
$ 75.97万 - 项目类别:
Cellular and molecular mechanisms of IgE cell memory in allergic responses
过敏反应中IgE细胞记忆的细胞和分子机制
- 批准号:
9987208 - 财政年份:2017
- 资助金额:
$ 75.97万 - 项目类别:
相似海外基金
Construction of affinity sensors using high-speed oscillation of nanomaterials
利用纳米材料高速振荡构建亲和传感器
- 批准号:
23H01982 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Affinity evaluation for development of polymer nanocomposites with high thermal conductivity and interfacial molecular design
高导热率聚合物纳米复合材料开发和界面分子设计的亲和力评估
- 批准号:
23KJ0116 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants
开发高亲和力和选择性配体作为多巴胺 D4 受体 (D4R) 亚型变体的药理学工具
- 批准号:
10682794 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Platform for the High Throughput Generation and Validation of Affinity Reagents
用于高通量生成和亲和试剂验证的平台
- 批准号:
10598276 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Collaborative Research: DESIGN: Co-creation of affinity groups to facilitate diverse & inclusive ornithological societies
合作研究:设计:共同创建亲和团体以促进多元化
- 批准号:
2233343 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Standard Grant
Collaborative Research: DESIGN: Co-creation of affinity groups to facilitate diverse & inclusive ornithological societies
合作研究:设计:共同创建亲和团体以促进多元化
- 批准号:
2233342 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Standard Grant
Molecular mechanisms underlying high-affinity and isotype switched antibody responses
高亲和力和同种型转换抗体反应的分子机制
- 批准号:
479363 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Operating Grants
Deconstructed T cell antigen recognition: Separation of affinity from bond lifetime
解构 T 细胞抗原识别:亲和力与键寿命的分离
- 批准号:
10681989 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
CAREER: Engineered Affinity-Based Biomaterials for Harnessing the Stem Cell Secretome
职业:基于亲和力的工程生物材料用于利用干细胞分泌组
- 批准号:
2237240 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Continuing Grant
ADVANCE Partnership: Leveraging Intersectionality and Engineering Affinity groups in Industrial Engineering and Operations Research (LINEAGE)
ADVANCE 合作伙伴关系:利用工业工程和运筹学 (LINEAGE) 领域的交叉性和工程亲和力团体
- 批准号:
2305592 - 财政年份:2023
- 资助金额:
$ 75.97万 - 项目类别:
Continuing Grant