Stroke Trials Network-Regional Coordinating Center University of Pittsburgh (STN-UP)

中风试验网络-匹兹堡大学区域协调中心 (STN-UP)

• 批准号: 10306019
• 负责人: MARCELO ROCHA
• 金额: $ 31.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10306019
• 关键词: Accident and Emergency department; Admission activity; Adopted; Adult; Advisory Committees; Agreement; Area; Cause of Death; Cessation of life; Childhood; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Communities; Community Outreach; Community Physician; Development; Devices; Education; Embolectomy; Enrollment; Ensure; Evaluation; Faculty; Fellowship; Fibrinolytic Agents; Fostering; Funding; Healthcare; Hospitals; Industry; Infrastructure; Institutes; Institution; Institutional Review Boards; Intervention; Leadership; Maryland; Measures; Mechanics; Medical; Medical center; Mission; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neuroprotective Agents; Neurosciences; Patient Recruitments; Patients; Pennsylvania; Pharmaceutical Preparations; Phase; Physicians; Population; Presbyterian Church; Public Health; Recovery; Rehabilitation therapy; Research; Research Personnel; Resources; Stroke; Stroke prevention; Structure; Support Groups; Telemedicine; Telephone; Training; Translational Research; United States; United States National Institutes of Health; Universities; acute stroke; base; career development; clinical care; community clinic; community partnership; cost; data management; design; education research; experience; innovation; lost earning; member; natural hypothermia; nervous system disorder; next generation; novel; outreach program; participant enrollment; participant retention; patient population; pre-clinical; programs; recruit; research study; robotic device; stem cell therapy; stroke clinical trials; stroke risk; stroke survivor; stroke therapy; stroke trials; success; telestroke; therapeutic development; treatment trial

The NIH Stroke Trials Network (StrokeNet) is designed to maximize efficiencies to prioritize, harmonize and streamline the development of high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery. The StrokeNet Regional Coordinating Center (RCC) at the University of Pittsburgh (STN-UP) plans to continue its successful clinical trials structure with improvements based upon our experiences during the initial term of RCC funding. The aims of this proposal to continue as STN-UP are: 1: To continue to build on our strengths as a dynamic, collaborative and sustainable administrative structure to rapidly implement stroke clinical trials and enroll patients across a wide range of adult and pediatric populations. 2: To foster participation of physicians, patients and patient support groups in the STN-UP. 3: To promote career development of young clinician-investigators in the neurosciences STN-UP will be led by the Program Director, Lawrence Wechsler, MD, co-Program Director Tudor Jovin, MD. Strengths of the STN-UP to continue participation as an RCC in the NIH StrokeNet are: 1) Consistent track record of high enrollment in NINDS and industry clinical trials. 2) Over 2000 yearly stroke admissions at three University of Pittsburgh Medical Center (UPMC) core hospitals (UPMC Presbyterian, UPMC Shadyside, and UPMC Mercy) 3) Large telestroke network including 28 hospitals in western Pennsylvania and Maryland with prior experience recruiting patients into stroke trials after telemedicine evaluation. 4) Extensive regional referral network with phone support to hospitals throughout the tri-state area. 5) Participation in StrokeNet, NETT and NeuroNEXT networks, and institutional support for tier-1 federated IRB and master clinical trial agreements. To continue the commitment of training the “next generation” of qualified stroke researchers, the STN-UP will: 1) Maintain our dedicated clinician researcher-oriented fellowship. 2) Recruit trainees to the Advisory Committee on a rotating basis. 3) Provide clinical trials education and experience for residents, fellows and junior faculty.

NIH卒中试验网络(StrokeNet)旨在最大限度地提高效率，以确定优先顺序、协调和 简化以卒中关键干预措施为重点的高质量、多地点临床试验的开发 预防、治疗和康复。加州大学StrokeNet区域协调中心(RCC) 匹兹堡(STN-UP)计划继续其成功的临床试验结构，基于我们的 在农村信用社初期资助期间的经验。这项提议作为STN-UP继续存在的目的是： 1：继续巩固我们作为一个充满活力、协作和可持续发展的行政架构的优势，以 快速实施中风临床试验，并在广泛的成人和儿童中招募患者 人口。 2：促进医生、患者和患者支持团体参与STN-UP。 3：促进神经科学领域年轻临床医生-研究人员的职业发展 STN-UP将由计划主任、医学博士Lawrence Wechsler、联合计划主任Tudor Jovin、 马里兰州STN-UP作为RCC继续参与NIH StrokeNet的优势在于： 1)NINDS和行业临床试验高登记的一致跟踪记录。 2)匹兹堡大学医学中心(UPMC)三所大学每年超过2000名中风患者 医院(UPMC长老会、UPMC Shadyside和UPMC Mercy) 3)大型远程中风网络，包括宾夕法尼亚州西部和马里兰州的28家医院，之前 在远程医疗评估后招募患者参加中风试验的经验。 4)广泛的区域转诊网络，为三州地区的医院提供电话支持。 5)参与StrokeNet、NETT和NeuroNEXT网络，并为第一级联合IRB提供机构支持 并掌握临床试验协议。 为了继续致力于培训合格的“下一代”中风研究人员，STN-UP将： 1)保持我们专注于临床医生研究人员的奖学金。 2)轮流向咨询委员会招收受训人员。 3)为住院医师、研究员和初级教师提供临床试验教育和经验。