Stroke Trials Network-Regional Coordinating Center University of Pittsburgh (STN-UP)

摘要 正在申请过渡性资金，以支持我们的NIH StrokeNet区域协调中心 匹兹堡大学(STN-UP)期间的资金缺口，否则就会在目前 奖励(U24NS107216)于2023年7月31日结束，拟议的新RCC奖励(RFA-NS-23-010)从 2023年12月1日。在此期间，NIH的持续支持对于STN-UP RCC继续交付至关重要 StrokeNet卒中试验的监管效率、学术专长和对高质量表现的监督 在我们的区域网络中进行预防、治疗和康复。领导、监督、管理和 由RCC Pi、Marcelo Rocha、Co-is、Clif Callaway、Dana Cummings和RCC提供的直接支持 经理杰森·韦默是继续参与和加入ASPIRE，Captiva，MOST， 土星，SleepSMART，TRANSPORT2和VERIFY试验。核心领导力将有助于及时 即将进行的RHSPSODY-2、FOCAS和SISTER研究的启动和多点启动 网络合作伙伴网站，这将发生在潜在的资金缺口期间。FOCAS是第一个 NIH儿童中风试验，STN-UP RCC将在UPMC儿童医院参加 匹兹堡。我们的RCC PI和研究经理每月与我们的区域卫星站点会面，以帮助优化 试点启动，全网高效招生。STN-UP将在其成功的基础上继续发展 基础设施和前几个资金周期的经验，以支持监管效率、学术专长、 在StrokeNet试验中，专注于中风的预防、治疗和恢复的高质量表现。我们的 大型STN-UP研究网络包括匹兹堡大学医学中心(UPMC)和圣卢克医院 覆盖宾夕法尼亚州大城市、郊区和农村地区的大学卫生医院，以支持试验 招募具有不同背景的中风患者。STN-UP RCC在 奖励之间的差距是：1.继续我们的协作和行政结构，迅速实施 StrokeNet在广泛的成人和儿科人群中进行试验和招募患者。2.培养参与度 医生、患者和患者支持团体具有平等的妇女和少数民族代表性，以 达到或超过权责发生制要求。

Abstract Bridge funding is being requested to support our NIH StrokeNet Regional Coordinating Center (RCC) at the University of Pittsburgh (STN-UP) during the gap in funding that would otherwise occur between the current award (U24NS107216) ending on 7/31/2023 and the proposed new RCC award (RFA-NS-23-010) starting on 12/1/2023. Continued NIH support during this time will be essential for the STN-UP RCC to continue delivering regulatory efficiency, academic expertise, and oversight of high-quality performance in StrokeNet trials of stroke prevention, treatment, and recovery across our regional network. The leadership, supervision, management, and direct support provided by the RCC PI, Marcelo Rocha, Co-Is, Clif Callaway and Dana Cummings and RCC Manager, Jason Weimer is key to continued participation and enrollment into the ASPIRE, CAPTIVA, MOST, SATURN, SleepSMART, TRANSPORT2 and VERIFY trials. Core leadership will be instrumental to the timely start-up and multi-site initiation for the upcoming RHSPSODY-2, FOCAS and SISTER trials across research network partner sites, which will be occurring during the time of the potential gap in funding. FOCAS is the first NIH pediatric stroke trial that the STN-UP RCC will be participating in at the UPMC Children’s Hospital of Pittsburgh. Our RCC PI and Research Manager meet monthly with our regional satellite sites to help optimize trial start-up and efficient enrollment across the network. STN-UP will continue to build on its successful infrastructure and experience from previous funding cycles to support regulatory efficiency, academic expertise, and high-quality performance in StrokeNet trials focused on stroke prevention, treatment, and recovery. Our large STN-UP research network includes University of Pittsburgh Medical Center (UPMC) and St. Luke’s University Health hospitals, covering large urban, suburban, and rural areas of Pennsylvania, to support trial recruitment of stroke participants with diverse backgrounds. The specific aims of the STN-UP RCC during the the gap between awards is to: 1. To continue our collaborative and administrative structure to rapidly implement StrokeNet trials and enroll patients across a wide range of adult and pediatric populations. 2. Foster participation of physicians, patients, and patient support groups with equitable representation of women and minorities to meet or exceed accrual requirements.