Novel Methods for Analysis of Genetic and Epigenetic Studies of Childhood Asthma

儿童哮喘遗传和表观遗传研究分析的新方法

• 批准号: 10304209
• 负责人: Qi Yan
• 金额: $ 14.3万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10304209
• 关键词: African American; Alabama; Asthma; Biological; Characteristics; Child; Childhood; Childhood Asthma; Communities; Complex; Computing Methodologies; DNA Methylation; Data; Data Set; Databases; Development; Disease; Doctor of Philosophy; Education; Environment; Epigenetic Process; Ethnic group; Floor; Future; Genes; Genetic; Genetic Transcription; Genetic study; Goals; Human Resources; Individual; Knowledge; Laboratories; Manuscripts; Mediating; Mediation; Mediator of activation protein; Mentors; Methods; Mexican; Modeling; Morbidity - disease rate; Not Hispanic or Latino; Pathogenesis; Pathway interactions; Pediatric Hospitals; Phenotype; Prevalence; Public Health; Puerto Rican; Qi; Research; Research Personnel; Resource Allocation; Sampling; Statistical Methods; Susceptibility Gene; Technology; Testing; Tissues; United States; Universities; Validation; Wages; Work; clinical care; clinical center; design; genetic analysis; genetic approach; genomic locus; high throughput analysis; interest; medical schools; mortality; multiple omics; novel; public health relevance; pulmonary function; symposium

PROJECT SUMMARY Title: Novel Methods for Analysis of Genetic and Epigenetic Studies of Childhood Asthma Candidate: Dr. Qi Yan is a junior biostatistician and statistical geneticist. He obtained his Ph.D. degree at the University of Alabama at Birmingham (2014). His main scientific interests lie in development and application of statistical and computational methods for analysis of high-throughput genetic and epigenetic data. He is author and co-author of 15 manuscripts, 11 of which are in the field of statistical genetics. Environment: Children's Hospital of Pittsburgh (CHP) of UPMC, affiliated with the University of Pittsburgh, School of Medicine, is a leading pediatric center for clinical care, research, and education excellence. Dr. Yan works in the new Rangos Research Center, comprised of 10 floors of state-of-the-art laboratories, offices, and conference facilities. In addition to superb mentoring by Dr. Daniel E. Weeks, Dr. Juan C. Celedón and Dr. Wei Chen, institutional commitment includes dedicated office space and resource allocation; shared personnel including clinicians and biologists, database manager, and laboratory staff; and guaranteed salary support until June 2017. Research: SIGNIFICANCE: The proposed project will develop novel statistical approaches for genetic and epigenetic analysis and the developed approaches should identify novel susceptibility genes and help researchers better understand the pathogenesis of childhood asthma in Puerto Ricans (PRs). The developed methods can be widely applied to other complex diseases with similar datasets. INNOVATION: The novel statistical approaches will be developed for integrative analysis of genetic and epigenetic data. AIMS: The goal of this proposal is to develop and apply sophisticated statistical approaches to identify genetic and epigenetic effects on childhood asthma in an integrative manner. APPROACH: In Aim1, we will develop novel statistical approaches for testing overall genetic and epigenetic effects on childhood asthma related phenotypes in PRs. In Aim2, we will develop novel statistical approaches for testing mediated genetic and epigenetic effects on childhood asthma related phenotypes in PRs. In Aim3, We will develop novel statistical methods for considering tissue or/and familial correlations when applying integrative analyses to PR childhood asthma samples.

项目摘要 标题：儿童哮喘遗传和表观遗传研究分析的新方法 候选人：齐燕博士是初级生物统计学家和统计遗传学家。他获得了博士学位。学位在 亚拉巴马大学伯明翰分校（2014年）。他的主要科学兴趣在于发展和应用 用于分析高通量遗传和表观遗传数据的统计和计算方法。他是作家 他是15篇论文的合著者，其中11篇属于统计遗传学领域。 环境：匹兹堡大学附属匹兹堡儿童医院， 医学院，是一个领先的儿科中心的临床护理，研究和教育卓越。严医生 在新的Rangos研究中心工作，由10层楼的最先进的实验室，办公室和 会议设施。除了丹尼尔博士的出色指导外，几周了，胡安·C·博士。塞莱东和魏博士 机构承诺包括专用办公场所和资源分配;共享人员 包括临床医生和生物学家，数据库管理员和实验室工作人员;并保证工资支持，直到 2017年6月。 研究：意义：拟议的项目将开发新的统计方法的遗传和 表观遗传学分析和已开发的方法应确定新的易感基因， 研究人员更好地了解了波多黎各儿童哮喘的发病机制。发达 该方法可以广泛应用于具有类似数据集的其他复杂疾病。创新：小说 将制定统计方法，对遗传和表观遗传数据进行综合分析。AIMS：目标 这项建议的一个重要方面是发展和应用复杂的统计方法来识别遗传和表观遗传 对儿童哮喘的综合影响。方法：在目标1中，我们将开发新的统计方法， 在PR中测试对儿童哮喘相关表型的总体遗传和表观遗传效应的方法。 在目标2中，我们将开发新的统计方法来测试介导的遗传和表观遗传效应， PR中的儿童哮喘相关表型。在目标3中，我们将开发新的统计方法， 当对PR儿童哮喘进行综合分析时，考虑组织或/和家族相关性 样品