Low-Field High-Performance MRI for Screening Clinically Significant Prostate Cancer
低场高性能 MRI 用于筛查有临床意义的前列腺癌
基本信息
- 批准号:10306404
- 负责人:
- 金额:$ 19.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-12-01 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAddressAdvisory CommitteesAmerican Cancer SocietyAmplifiersAreaBiopsyBlood TestsCancer EtiologyClinicalDepositionDetectionDiagnosisDiagnosticDiagnostic ImagingDiffusionDiffusion Magnetic Resonance ImagingDiseaseEarly DiagnosisEarly treatmentEvaluationFellowshipFundingGasesHeliumHip region structureHumanImageImage EnhancementIncidenceIntestinesLiteratureMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of prostateMeasurementMethodologyMethodsNoiseOwnershipPSA screeningPathway interactionsPatientsPerformancePlayPopulationPredispositionPreventiveProstateProstate-Specific AntigenProtocols documentationReportingResearchResolutionRoleSafetySamplingScanningScreening for Prostate CancerScreening procedureSensitivity and SpecificitySignal TransductionSourceSpecificitySystemT2 weighted imagingTechniquesTestingTimeTrainingUnited StatesUnited States National Institutes of HealthUrsidae Familyagedbasecancer careclinical implementationclinically significantcontrast enhancedcostcost estimatedeep learningdenoisingdesigneconomic impacthead-to-head comparisonhealthy volunteerimage reconstructionimaging scientistimaging systemimprovedinnovationlight weightmalemenmortalitynoveloperationprostate lesionsprototyperadiologistreconstructionscreeningscreening guidelinestheoriestumorvolunteer
项目摘要
Project Summary/Abstract
Prostate cancer (PCa) is the most common malignancy and is the 2nd leading cause of cancer-related mortality
in males in the United States. Despite high incidence and tremendous human and economic impact of PCa,
there is no good screening test for clinically significant PCa. Commonly used blood test for Prostate Specific
Antigen (PSA) is inexpensive but lack specificity for clinically significant PCa. Over the last decade, multi-
parametric prostate MRI has been shown to have an increasingly important role in the detection and
localization of clinically significant PCa. Despite the demonstrated value of prostate MRI, there are two major
challenges in clinical implementation of prostate MRI as a first-line screening tool at a population level: (1) high
cost of the scanner and the exam, which decreases accessibility, and (2) lack of robustness of the MRI exam.
To overcome these limitations we propose establishing a low-field, robust, widely accessible, and thus low-
cost high-performance MRI system for PCa screening. Major challenges for imaging at lower field strength
is the lower signal to noise (SNR) and thus longer acquisition times compared to 1.5 and 3.0 T. In this
proposal we aim to address these efficiency and scan time challenges at low field. Our team of clinical
and imaging scientists will bring to bear novel acquisition and reconstruction techniques to restore SNR,
specifically random matrix theory (RMT- a technique our center has recently introduced), and deep-learning-
based image reconstruction (an area our group has helped to pioneer). We will evaluate these techniques in
healthy volunteers and patients with PCa. Subsequently, we will perform head-to-head comparison of low-field
bi-parametric exam to routine clinical 1.5 T or 3.0 T MRI exams in 30 patients with known or suspected PCa.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hersh Chandarana其他文献
Hersh Chandarana的其他文献
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{{ truncateString('Hersh Chandarana', 18)}}的其他基金
Advanced Diffusion Imaging for Management of Renal Cancer: Oncologic Control and Renal Functional Reserve - Resubmission - 1
用于肾癌治疗的先进扩散成像:肿瘤控制和肾功能储备 - 重新提交 - 1
- 批准号:
10380147 - 财政年份:2020
- 资助金额:
$ 19.41万 - 项目类别:
Advanced Diffusion Imaging for Management of Renal Cancer: Oncologic Control and Renal Functional Reserve - Resubmission - 1
用于肾癌治疗的先进扩散成像:肿瘤控制和肾功能储备 - 重新提交 - 1
- 批准号:
10212354 - 财政年份:2020
- 资助金额:
$ 19.41万 - 项目类别:
Advanced Diffusion Imaging for Management of Renal Cancer: Oncologic Control and Renal Functional Reserve - Resubmission - 1
用于肾癌治疗的先进扩散成像:肿瘤控制和肾功能储备 - 重新提交 - 1
- 批准号:
10625960 - 财政年份:2020
- 资助金额:
$ 19.41万 - 项目类别:
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