Low-Field High-Performance MRI for Screening Clinically Significant Prostate Cancer

低场高性能 MRI 用于筛查有临床意义的前列腺癌

• 批准号: 10306404
• 负责人: Hersh Chandarana
• 金额: $ 19.41万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10306404
• 关键词: Acoustics; Address; Advisory Committees; American Cancer Society; Amplifiers; Area; Biopsy; Blood Tests; Cancer Etiology; Clinical; Deposition; Detection; Diagnosis; Diagnostic; Diagnostic Imaging; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Early Diagnosis; Early treatment; Evaluation; Fellowship; Funding; Gases; Helium; Hip region structure; Human; Image; Image Enhancement; Incidence; Intestines; Literature; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Methodology; Methods; Noise; Ownership; PSA screening; Pathway interactions; Patients; Performance; Play; Population; Predisposition; Preventive; Prostate; Prostate-Specific Antigen; Protocols documentation; Reporting; Research; Resolution; Role; Safety; Sampling; Scanning; Screening for Prostate Cancer; Screening procedure; Sensitivity and Specificity; Signal Transduction; Source; Specificity; System; T2 weighted imaging; Techniques; Testing; Time; Training; United States; United States National Institutes of Health; Ursidae Family; aged; base; cancer care; clinical implementation; clinically significant; contrast enhanced; cost; cost estimate; deep learning; denoising; design; economic impact; head-to-head comparison; healthy volunteer; image reconstruction; imaging scientist; imaging system; improved; innovation; light weight; male; men; mortality; novel; operation; prostate lesions; prototype; radiologist; reconstruction; screening; screening guidelines; theories; tumor; volunteer

Project Summary/Abstract Prostate cancer (PCa) is the most common malignancy and is the 2nd leading cause of cancer-related mortality in males in the United States. Despite high incidence and tremendous human and economic impact of PCa, there is no good screening test for clinically significant PCa. Commonly used blood test for Prostate Specific Antigen (PSA) is inexpensive but lack specificity for clinically significant PCa. Over the last decade, multi- parametric prostate MRI has been shown to have an increasingly important role in the detection and localization of clinically significant PCa. Despite the demonstrated value of prostate MRI, there are two major challenges in clinical implementation of prostate MRI as a first-line screening tool at a population level: (1) high cost of the scanner and the exam, which decreases accessibility, and (2) lack of robustness of the MRI exam. To overcome these limitations we propose establishing a low-field, robust, widely accessible, and thus low- cost high-performance MRI system for PCa screening. Major challenges for imaging at lower field strength is the lower signal to noise (SNR) and thus longer acquisition times compared to 1.5 and 3.0 T. In this proposal we aim to address these efficiency and scan time challenges at low field. Our team of clinical and imaging scientists will bring to bear novel acquisition and reconstruction techniques to restore SNR, specifically random matrix theory (RMT- a technique our center has recently introduced), and deep-learning- based image reconstruction (an area our group has helped to pioneer). We will evaluate these techniques in healthy volunteers and patients with PCa. Subsequently, we will perform head-to-head comparison of low-field bi-parametric exam to routine clinical 1.5 T or 3.0 T MRI exams in 30 patients with known or suspected PCa.

项目摘要/摘要 前列腺癌(Pca)是最常见的恶性肿瘤，是癌症相关死亡的第二大原因。 在美国的男性中。尽管PCA的发病率很高，对人类和经济造成了巨大的影响， 对于具有临床意义的前列腺癌，目前尚无良好的筛查试验。前列腺特异性的常用血液检测方法 抗原(PSA)价格低廉，但对有临床意义的PCa缺乏特异性。在过去的十年里，多 参数前列腺MRI已被证明在检测和诊断前列腺癌方面发挥着越来越重要的作用。 临床上有意义的前列腺癌的定位。尽管前列腺核磁共振的价值得到了证实，但有两个主要原因 作为人群一级筛查工具的前列腺癌MRI临床应用面临的挑战：(1)高 扫描仪和检查的成本，这降低了可访问性，以及(2)MRI检查缺乏稳健性。 为了克服这些限制，我们建议建立一个低场、健壮、可广泛访问的，从而 性价比高的高性能核磁共振系统用于前列腺癌筛查。低场强成像面临的主要挑战 与1.5和3.0 T相比，信噪比(SNR)更低，因此采集时间更长。 我们的目标是在低场下解决这些效率和扫描时间的挑战。我们的临床团队 成像科学家将采用新的采集和重建技术来恢复SNR， 特别是随机矩阵理论(RMT-我们中心最近引入的一种技术)，以及深度学习- 基于图像重建(我们团队帮助开创的一个领域)。我们将在以下项目中评估这些技术 健康志愿者和前列腺癌患者。随后，我们将进行低场的面对面比较 对30例已知或疑似前列腺癌患者进行常规1.5T或3.0T磁共振检查的双参数检查。