Effects of Electrical Stimulation and Vitamin D supplementation on Bone Health Following Spinal Cord Injury.

电刺激和补充维生素 D 对脊髓损伤后骨骼健康的影响。

• 批准号: 10315332
• 负责人: Dora E. Ifon
• 金额: --
• 依托单位: VA VETERANS ADMINISTRATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10315332
• 关键词: Address; Adherence; Affect; Age-Years; Alkaline Phosphatase; Analysis of Variance; Androgens; Architecture; Attenuated; Biological Assay; Biological Markers; Blood specimen; Bone Density; Bone Resorption; Bone remodeling; Calcium; Chronic; Clinical; Collagen Type I; Complication; Consensus; Cyclophosphamide; Data; Deterioration; Disease; Distal; Dose; Dual-Energy X-Ray Absorptiometry; Economic Burden; Electric Stimulation; Enrollment; Evaluation; Exercise; Experimental Designs; Family; Fatty acid glycerol esters; Femur; Fracture; Healthcare Systems; Home; Hydroxyproline; Individual; Injury; Intervention; Intramuscular; Life; Limb structure; Link; Magnesium; Magnetic Resonance Imaging; Measurement; Measures; Medical; Medical Research; Microscopic; Motor; Movement; Muscle; N-terminal; Oral; Osteogenesis; Osteoporosis; PTH gene; Paralysed; Participant; Persons; Pharmacologic Substance; Physical activity; Pilot Projects; Process; Procollagen; Property; Protocols documentation; Quality of life; Randomized; Rehabilitation therapy; Replacement Therapy; Risk; Role; Serum; Skeletal Muscle; Spinal cord injury; Structure; Supplementation; Surface; Time; Training; Veterans; Vitamin D; Vitamin D Deficiency; Vitamin D supplementation; Work; attenuation; base; bone; bone health; bone loss; bone quality; bone turnover; comorbidity; crosslink; demineralization; experience; improved; kinematics; long bone; mechanical load; muscle hypertrophy; neuromuscular stimulation; osteoporosis with pathological fracture; post intervention; rehabilitation paradigm; strength training; substantia spongiosa; telehealth; tibia; trial design

Project Summary/Abstract Neurogenic osteoporosis is a devastating problem that is likely to impact 46,000 Veterans with chronic spinal cord injury (SCI). It is typically associated with low impact fractures of long bones and other medical comorbidities. It is estimated that approximately fifty percent of all individuals with SCI will develop low impact fracture during their lifetime. The management of osteoporosis related fractures can impose substantial economic burden on the health care system, individuals with SCI and their families. Advancement in medical research clearly indicated that neurogenic osteoporosis is linked to reduced loading and Vitamin D (Vit D) deficiency. Our pilot work indicated that a simple rehabilitation paradigm targeting towards evoking skeletal muscle hypertrophy may attenuate deterioration in trabecular bone parameters after SCI. Evoked resistance training (RT) using surface neuromuscular electrical stimulation (NMES) has been shown as a successful and feasible home-based approach to load skeletal muscles after SCI. Our earlier results may imply long term compliance and adherence if successfully applied in conjunction with a telehealth approach. In the present study, we propose a simple home-based approach of using NMES RT in conjunction with oral Vit D supplementation on trabecular bone quality in 20 Veterans with chronic SCI. Data will include measurements of trabecular bone quality as determined by magnetic resonance imaging (MRI) and bone biomarkers associated with the process of bone remodeling. Twenty participants with chronic (> 1-year post-injury) motor complete (AIS A and B) SCI (18 to 65 years of age) will be randomly assigned into either NMES RT plus 2000IU of Vit D (10 participants) or passive movement plus 2000IU Vit D (10 participants) to participate in a repeated measure design trial for 9 months. The NMES RT plus Vit D will undergo 4.5 months of open kinematic chain resistance training followed by 4.5 months of closed kinematic chain using simple rowing approach. This pilot work will have two main specific aims. Aim 1. To determine the impact of home based NMES RT protocol plus oral Vit D supplementation compared to passive movement plus oral Vit D on bone microarchitectural properties. Aim 2. To determine the impact of home based NMES RT protocol plus oral Vit D compared to passive movement and Vit D supplementation on biomarkers of bone formation and bone resorption. Key words: Spinal cord injury, osteoporosis, bone turnover, bone remodeling, bone biomarkers, electrical stimulation, vitamin D.

项目总结/摘要 神经源性骨质疏松症是一个毁灭性的问题，可能会影响46，000 慢性脊髓损伤（SCI）患者。它通常与低冲击断裂有关 长骨和其他内科合并症的症状据估计，大约百分之五十的 所有SCI患者在其一生中都会发生低冲击性骨折。管理 与骨质疏松症相关的骨折会给医疗保健带来巨大的经济负担 系统，SCI患者及其家人。医学研究的进步 表明，神经性骨质疏松症与负荷减少和维生素D（维生素D） 缺陷我们的试点工作表明，一个简单的康复模式， 引起骨骼肌肥大可减轻骨小梁参数的恶化 SCI之后使用表面神经肌肉电刺激的诱发阻力训练（RT） （NMES）已被证明是一个成功的和可行的家庭为基础的方法来加载骨骼 SCI后的肌肉我们早期的结果可能意味着长期合规性和遵守，如果 与远程保健方法一起成功应用。在本研究中，我们提出 一个简单的家庭为基础的方法，使用NMES RT结合口服维生素D 20例慢性脊髓损伤退伍军人骨小梁质量的补充。数据将包括 通过磁共振成像（MRI）测定的骨小梁质量测量值 以及与骨重建过程相关的骨生物标志物。 20名慢性（伤后> 1年）运动完全性（AIS A和B）SCI受试者 (18至65岁）将随机分配至NMES RT +2000 IU维生素D（10 参与者）或被动运动加2000 IU维生素D（10名参与者）参加 重复测量设计试验9个月。NMES RT加维生素D将持续4.5个月 开放式运动链阻力训练，然后进行4.5个月的封闭式运动链训练 使用简单的划船方法。这项试点工作将有两个主要的具体目标。目标1.到 确定基于家庭的NMES RT方案加口服维生素D补充剂的影响 与被动运动加口服维生素D对骨微结构特性的影响相比。目标二。 确定基于家庭的NMES RT方案加口服维生素D与被动治疗相比的影响 运动和维生素D补充对骨形成和骨吸收的生物标志物的影响。 关键词：脊髓损伤，骨质疏松症，骨转换，骨重建，骨生物标志物， 电刺激维生素D