Development and Commercialization of the Microphysiological Systems Database as a Sustainable Resource

微生理系统数据库作为可持续资源的开发和商业化

• 批准号: 10312124
• 负责人: ALBERT H GOUGH
• 金额: $ 148.18万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-05 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312124
• 关键词: Adoption; Animal Organ; Animals; Biological Sciences; Biotechnology; Businesses; Clinical; Collaborations; Communities; Complement; Computer Models; Data; Database Management Systems; Databases; Development; Disease Pathway; Disease Progression; Ensure; Experimental Models; Functional disorder; Future; Goals; Human; Industrialization; Industry; Infrastructure; Joints; Knowledge; Lead; Licensing; Maintenance; Marketing; Measures; Metadata; Methods; Performance; Persons; Physiology; Process; Provider; Quality Control; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; Sales; Secure; Security; Site; Statistical Data Interpretation; Structure; Technology; Testing; Tissue Banks; Tissue Microarray; Toxicology; Translations; Work; commercialization; comparative; controlled release; data mining; data modeling; data quality; data sharing; design; drug discovery; drug efficacy; experience; federated computing; firewall; improved; in vivo; information model; innovation; medication safety; member; microphysiology system; new technology; open source; pre-clinical; programs; quality assurance; recruit; success; sustainable resource; tool

Abstract The Micorphysiology Systems Database Center (MPS-DbC) developed and implemented the Microphysiology database (MPS-Db) enabling the management, analysis, sharing, integration of diverse information and computational modeling of data in one platform, improving the systematic way MPS users work. Aggregation of metadata, experimental data, and references provides for robust and relevant interpretation of the results, and having the data centrally located facilitates data sharing among user-defined collaborators and groups. Ready access to experimental data, metadata, and reference data in a mineable format provides a convenient platform for statistical analysis of MPS performance, and building computational modeling tools to predict PK, identify compound mechanisms of actions, and infer pathways of disease progression. We have been assisting users in capturing and managing MPS data, and the MPS-Db is the central repository for the Tissue Chip Testing Center program data. We propose to build the research and commercial value of the MPS-Db by: 1) continuing to support MPS users to build database content; 2) enabling on-line preclinical/clinical concordance analysis capabilities; 3) enhancing the suite of data mining and computational modeling tools; and 4) augmenting methods for ensuring data quality and the secure, controlled release of data to user-defined groups. We will implement a commercial version of the MPS-Db that can reside on a controlled network behind corporate firewalls for the management of proprietary data while still providing access to public MPS resources. Finally, we propose to establish a self- sustaining MPS-Db and experimental analytics company that will generate revenue from commercial users for the maintenance and further development of the MPS-Db for all users.

摘要 微生理学系统数据库中心（MPS-DbC）开发并实施了 微生理学数据库（MPS-Db），能够管理、分析、共享、整合 在一个平台中提供多样化的信息和数据计算建模， MPS用户工作的系统方式。元数据、实验数据和参考文献的聚合 提供了对结果的可靠和相关的解释，并集中拥有数据 located有助于用户定义的协作者和组之间的数据共享。随时获得 实验数据、元数据和参考数据以可挖掘的格式提供了一个方便的 MPS性能统计分析平台，并构建计算建模工具 预测PK，确定化合物的作用机制，并推断疾病的途径 进展我们一直协助用户获取和管理MPS数据， MPS-Db是组织芯片测试中心程序数据的中央存储库。我们提出 建立MPS-Db的研究和商业价值：1）继续支持MPS 用户建立数据库内容; 2）实现在线临床前/临床一致性分析 能力; 3）增强数据挖掘和计算建模工具套件;以及4） 增强确保数据质量和数据安全、受控发布的方法， 用户定义的组。我们将实现MPS-Db的商业版本， 在公司防火墙后面的受控网络上管理专有数据， 仍然提供公共MPS资源的访问。最后，我们建议建立一个自我- 维持MPS-Db和实验分析公司，将产生收入， 为所有用户维护和进一步开发MPS-Db。