权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Spontaneous Speech and Health Disparities in Risk of Cognitive Decline: WHICAP Offspring Ancillary Study

自发言语和认知衰退风险的健康差异：WHICAP 后代辅助研究

基本信息

批准号：
10314058
负责人：
ADAM M BRICKMAN
金额：
$ 66.55万
依托单位：
KENT STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10314058
关键词：
African American African American population Aging Alleles Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid Amyloid deposition Ancillary Study Biological Biological Markers Brain Cardiovascular Diseases Cellular Phone Cognitive Complex Analysis Data Data Collection Early Diagnosis Education Elderly Enrollment Ethnic Origin Ethnic group Exhibits Future Hippocampus (Brain)Hispanic Hispanic Populations Image Impaired cognition Incidence Income Individual Language Magnetic Resonance Imaging Measures Mediator of activation protein Medical Genetics Methods Minority Minority Groups Monitor Multilingualism Names Nerve Degeneration Neuronal Plasticity Neuropsychological Tests Neuropsychology Not Hispanic or Latino Parents Participant Population Population Heterogeneity Positron-Emission Tomography Race Research Risk Risk Factors Sampling Semantics Speech Thinness Time Variant Washington Work apolipoprotein E-4 bilingualism burden of illness cognitive function cognitive reserve cohort community setting ethnic diversity executive function genetic testing health disparity indexing insight instrument lexical novel marker offspring perceived discrimination pre-clinical protective effect racial and ethnic racial and ethnic disparities relating to nervous system screening social culture tau Proteins white matter

项目摘要

Project Summary/Abstract The proposed ancillary study looks to better understand racial/ethnic disparities in Alzheimer's disease (AD) by investigating spontaneous speech as part of the Washington Heights/Inwood Columbia Aging Project (WHICAP) Offspring Study. Limitations of existing cognitive screening instruments is a known contributor to racial/ethnic disparities in AD and recent work suggests that speech analysis may be a sensitive marker of cognitive decline and future AD. New technological advances raise the possibility that automated speech analysis could be conducted using smartphones in community settings, creating an inexpensive and scalable approach to early detection. However, many challenges remain in developing this method, including a very limited understanding of the biological underpinnings of spontaneous speech in at-risk individuals (e.g., hippocampal volume, amyloid deposition, contribution of executive function vs. language). We propose to examine spontaneous speech as part of the ongoing WHICAP Offspring Study (RF1AG054070, RF1AG058067). This large project is enrolling a diverse cohort (>70% minorities) of pre-clinical participants with varying degrees of risk for AD using medical, genetic, and neuropsychological testing (N = 3000), structural MRI (N = 1000), and amyloid and tau PET imaging (N = 150 for each). Both English and Spanish speakers are included. One measure of spontaneous speech has been included since study onset and a second brief measure would be added. We hypothesize that spontaneous speech will reflect a combination of both biological and sociocultural risk factors to AD and that bilingualism will show protective effects. By leveraging the rich data collection of the WHICAP Offspring Study, this application would generate substantial new insight into the basic underpinnings of spontaneous speech in diverse pre-clinical samples, as well as determine the feasibility of using speech analysis as a novel biomarker of AD risk. Additionally, should the cohort be followed longitudinally, the ability of spontaneous speech to predict future incidence of AD in racially/ethnically diverse samples over time could also be evaluated.

项目总结/文摘