Basolateral amygdala circuits in defensive behavior regulation
基底外侧杏仁核回路在防御行为调节中的作用
基本信息
- 批准号:10311537
- 负责人:
- 金额:$ 34.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-02-12 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:ASIC channelAmygdaloid structureAsphyxiaBehaviorBehavioralBrainCarbon DioxideDataElectrophysiology (science)EnvironmentEquilibriumFoundationsFreezingGeneticGlutamatesGoalsHumanImpairmentInhalationInhibitory SynapseInterneuronsKnowledgeLesionMediatingMental DepressionMental disordersMusNational Institute of Mental HealthNegative ValenceNeurobiologyNeuronsOutputPanicPanic DisorderParvalbuminsPlayPopulationPositioning AttributePost-Traumatic Stress DisordersProcessPsychotic DisordersRegulationReproducibilityResearch Domain CriteriaRoleSignal TransductionSiteSomatostatinSymptomsSystemTestingTranslational ResearchTranslationsWorkbasebehavioral responseconditioned fearexperimental studyfightingimprovedinnovationoptogeneticsreceptorrelating to nervous systemresponse
项目摘要
Abstract
Survival in a hostile environment requires the ability to assess potential threats and take the most appropriate
defensive action. Accumulating evidence suggests that the amygdala is well positioned to integrate information
about threats and to guide or shift responses along a spectrum of potential defensive behaviors. In both
humans and mice, the amygdala plays an essential role in defensive responses to the threat of suffocation,
signaled by rising systemic carbon dioxide (CO2) levels in the body. Lesioning the amygdala, or manipulating it
more precisely in other ways, reduces some defensive behaviors evoked by CO2 inhalation (e.g. freezing)
while simultaneously increasing others (e.g. fight-or-flight). Because CO2 inhalation evokes a variety of
defensive responses in a robust, reproducible, and concentration-dependent manner, CO2 provides a
straightforward and translatable approach to studying the amygdala's role in defensive behavior regulation. In
this application, we propose to study defensive behaviors evoked by CO2 using state-of-the-art, neuron-
specific manipulations and electrophysiological recording to deconstruct roles of select neuron populations in
the basolateral amygdala (BLA). We hypothesize that distinct defensive behaviors are differentially regulated
by the BLA and that principal neurons and interneurons in the BLA each play unique roles. To test this
hypothesis we will use genetic, optogenetic, and electrophysiological approaches to specifically activate and
silence specific BLA neuron populations and quantify the effects on neural activity and defensive behaviors.
Together these experiments will allow us to discern how these neurons regulate different defensive behaviors.
Understanding basic mechanisms that guide or shift defensive behaviors along their spectrum will be essential
for identifying abnormalities in these processes and for finding ways to correct them. This knowledge will
ultimately impact mental illnesses where defensive behaviors are inappropriately extreme such as panic
disorder and post-traumatic stress disorder.
抽象的
在敌对环境中生存需要能够评估潜在威胁并采取最适当的措施
防御行动。越来越多的证据表明杏仁核能够很好地整合信息
威胁并指导或改变一系列潜在防御行为的反应。在两者中
在人类和小鼠中,杏仁核在对窒息威胁的防御反应中发挥着重要作用,
由体内全身二氧化碳 (CO2) 水平升高发出信号。损害或操纵杏仁核
更准确地说,在其他方面,减少吸入二氧化碳引起的一些防御行为(例如冻结)
同时增加其他因素(例如战斗或逃跑)。因为吸入二氧化碳会引起多种
CO2 以稳健、可重复且浓度依赖性的方式产生防御反应,
研究杏仁核在防御行为调节中的作用的直接且可转化的方法。在
在这个应用中,我们建议使用最先进的神经元来研究二氧化碳引起的防御行为
特定的操作和电生理记录来解构选定神经元群的作用
基底外侧杏仁核(BLA)。我们假设不同的防御行为受到不同的调节
BLA 中的主要神经元和中间神经元各自发挥着独特的作用。为了测试这个
假设我们将使用遗传、光遗传学和电生理学方法来特异性激活和
沉默特定的 BLA 神经元群体并量化对神经活动和防御行为的影响。
这些实验将使我们能够了解这些神经元如何调节不同的防御行为。
了解引导或改变防御行为的基本机制至关重要
识别这些过程中的异常情况并找到纠正方法。这些知识将
最终影响精神疾病,其中防御行为过度极端,例如恐慌
障碍和创伤后应激障碍。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status.
双相情感障碍的超秒间隔计时:检查障碍亚型、情绪和药物状态的作用。
- DOI:10.21203/rs.3.rs-3006203/v1
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:MüllerEwald,VictόriaA;Trapp,NicholasT;Sarrett,McCallE;Pace,BenjaminD;Wendt,Linder;Richards,JennyG;Gala,IlisaK;Miller,JacobN;Wessel,JanR;Magnotta,VincentA;Wemmie,JohnA;Boes,AaronD;Parker,KrystalL
- 通讯作者:Parker,KrystalL
Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.
- DOI:10.1111/adb.12690
- 发表时间:2020-03
- 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.
- DOI:10.1111/head.13917
- 发表时间:2020-10
- 期刊:
- 影响因子:5
- 作者:Sowers LP;Wang M;Rea BJ;Taugher RJ;Kuburas A;Kim Y;Wemmie JA;Walker CS;Hay DL;Russo AF
- 通讯作者:Russo AF
Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.
- DOI:10.1007/s11682-021-00552-2
- 发表时间:2022-04
- 期刊:
- 影响因子:3.2
- 作者:Shaffer JJ Jr;Willour V;Fiedorowicz JG;Christensen GE;Long JD;Johnson CP;Schmitz SL;Williams AJ;Wemmie J;Magnotta VA
- 通讯作者:Magnotta VA
Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.
- DOI:10.3389/fpsyt.2020.532606
- 发表时间:2020
- 期刊:
- 影响因子:4.7
- 作者:Shaffer JJ Jr;Mani M;Schmitz SL;Xu J;Owusu N;Wu D;Magnotta VA;Wemmie JA
- 通讯作者:Wemmie JA
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
John A Wemmie其他文献
John A Wemmie的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('John A Wemmie', 18)}}的其他基金
Novel mechanisms for correcting opioid-induced synaptic abnormalities
纠正阿片类药物引起的突触异常的新机制
- 批准号:
10610455 - 财政年份:2021
- 资助金额:
$ 34.07万 - 项目类别:
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
研究阿片类药物诱导的突触可塑性和行为的新调控途径
- 批准号:
10516021 - 财政年份:2019
- 资助金额:
$ 34.07万 - 项目类别:
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
研究阿片类药物诱导的突触可塑性和行为的新调控途径
- 批准号:
10292973 - 财政年份:2019
- 资助金额:
$ 34.07万 - 项目类别:
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
研究阿片类药物诱导的突触可塑性和行为的新调控途径
- 批准号:
10066256 - 财政年份:2019
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
7929354 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
8597367 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
ASICs in the n. accumbens in depression-related synaptic plasticity and behavior
n 中的 ASIC。
- 批准号:
8967085 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
8196333 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
8391587 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Modeling CO2-evoked fear in mice: role of acid-sensing ion channels
模拟二氧化碳引起的小鼠恐惧:酸敏感离子通道的作用
- 批准号:
8231507 - 财政年份:2009
- 资助金额:
$ 34.07万 - 项目类别: