Basolateral amygdala circuits in defensive behavior regulation
基底外侧杏仁核回路在防御行为调节中的作用
基本信息
- 批准号:10311537
- 负责人:
- 金额:$ 34.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-02-12 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:ASIC channelAmygdaloid structureAsphyxiaBehaviorBehavioralBrainCarbon DioxideDataElectrophysiology (science)EnvironmentEquilibriumFoundationsFreezingGeneticGlutamatesGoalsHumanImpairmentInhalationInhibitory SynapseInterneuronsKnowledgeLesionMediatingMental DepressionMental disordersMusNational Institute of Mental HealthNegative ValenceNeurobiologyNeuronsOutputPanicPanic DisorderParvalbuminsPlayPopulationPositioning AttributePost-Traumatic Stress DisordersProcessPsychotic DisordersRegulationReproducibilityResearch Domain CriteriaRoleSignal TransductionSiteSomatostatinSymptomsSystemTestingTranslational ResearchTranslationsWorkbasebehavioral responseconditioned fearexperimental studyfightingimprovedinnovationoptogeneticsreceptorrelating to nervous systemresponse
项目摘要
Abstract
Survival in a hostile environment requires the ability to assess potential threats and take the most appropriate
defensive action. Accumulating evidence suggests that the amygdala is well positioned to integrate information
about threats and to guide or shift responses along a spectrum of potential defensive behaviors. In both
humans and mice, the amygdala plays an essential role in defensive responses to the threat of suffocation,
signaled by rising systemic carbon dioxide (CO2) levels in the body. Lesioning the amygdala, or manipulating it
more precisely in other ways, reduces some defensive behaviors evoked by CO2 inhalation (e.g. freezing)
while simultaneously increasing others (e.g. fight-or-flight). Because CO2 inhalation evokes a variety of
defensive responses in a robust, reproducible, and concentration-dependent manner, CO2 provides a
straightforward and translatable approach to studying the amygdala's role in defensive behavior regulation. In
this application, we propose to study defensive behaviors evoked by CO2 using state-of-the-art, neuron-
specific manipulations and electrophysiological recording to deconstruct roles of select neuron populations in
the basolateral amygdala (BLA). We hypothesize that distinct defensive behaviors are differentially regulated
by the BLA and that principal neurons and interneurons in the BLA each play unique roles. To test this
hypothesis we will use genetic, optogenetic, and electrophysiological approaches to specifically activate and
silence specific BLA neuron populations and quantify the effects on neural activity and defensive behaviors.
Together these experiments will allow us to discern how these neurons regulate different defensive behaviors.
Understanding basic mechanisms that guide or shift defensive behaviors along their spectrum will be essential
for identifying abnormalities in these processes and for finding ways to correct them. This knowledge will
ultimately impact mental illnesses where defensive behaviors are inappropriately extreme such as panic
disorder and post-traumatic stress disorder.
摘要
在敌对环境中生存需要评估潜在威胁的能力,并采取最适当的措施。
防御行动。越来越多的证据表明杏仁核在整合信息方面处于有利地位
并引导或改变反应沿着一系列潜在的防御行为。无论是
对于人类和小鼠,杏仁核在对窒息威胁的防御反应中起着重要作用,
通过体内系统二氧化碳(CO2)水平升高发出信号。损害杏仁核,或者操纵它
更确切地说,在其他方面,减少了由CO2吸入引起的一些防御行为(例如冻结)
而同时增加其他的(例如战斗或逃跑)。因为吸入二氧化碳会引起各种
防御反应在一个强大的,可重复的,和浓度依赖性的方式,二氧化碳提供了一个
这是一种直接和可翻译的方法来研究杏仁核在防御行为调节中的作用。在
本申请中,我们建议使用最先进的神经元研究CO2诱发的防御行为,
特定的操作和电生理记录,以解构选择的神经元群体在
基底外侧杏仁核(BLA)。我们假设不同的防御行为受到不同的调节,
BLA中的主要神经元和中间神经元各自发挥独特的作用。为了验证这一
假设我们将使用遗传学、光遗传学和电生理学方法来特异性激活和
沉默特定的BLA神经元群体,并量化对神经活动和防御行为的影响。
这些实验将使我们能够辨别这些神经元如何调节不同的防御行为。
理解引导或改变防御行为的基本机制将是至关重要的
用于识别这些过程中的异常并找到纠正它们的方法。这些知识将
最终影响心理疾病,其中防御行为是不适当的极端,
创伤后应激障碍。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status.
双相情感障碍的超秒间隔计时:检查障碍亚型、情绪和药物状态的作用。
- DOI:10.21203/rs.3.rs-3006203/v1
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:MüllerEwald,VictόriaA;Trapp,NicholasT;Sarrett,McCallE;Pace,BenjaminD;Wendt,Linder;Richards,JennyG;Gala,IlisaK;Miller,JacobN;Wessel,JanR;Magnotta,VincentA;Wemmie,JohnA;Boes,AaronD;Parker,KrystalL
- 通讯作者:Parker,KrystalL
Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.
- DOI:10.1111/adb.12690
- 发表时间:2020-03
- 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.
- DOI:10.1111/head.13917
- 发表时间:2020-10
- 期刊:
- 影响因子:5
- 作者:Sowers LP;Wang M;Rea BJ;Taugher RJ;Kuburas A;Kim Y;Wemmie JA;Walker CS;Hay DL;Russo AF
- 通讯作者:Russo AF
Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.
- DOI:10.1007/s11682-021-00552-2
- 发表时间:2022-04
- 期刊:
- 影响因子:3.2
- 作者:Shaffer JJ Jr;Willour V;Fiedorowicz JG;Christensen GE;Long JD;Johnson CP;Schmitz SL;Williams AJ;Wemmie J;Magnotta VA
- 通讯作者:Magnotta VA
Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.
- DOI:10.3389/fpsyt.2020.532606
- 发表时间:2020
- 期刊:
- 影响因子:4.7
- 作者:Shaffer JJ Jr;Mani M;Schmitz SL;Xu J;Owusu N;Wu D;Magnotta VA;Wemmie JA
- 通讯作者:Wemmie JA
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John A Wemmie其他文献
John A Wemmie的其他文献
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{{ truncateString('John A Wemmie', 18)}}的其他基金
Novel mechanisms for correcting opioid-induced synaptic abnormalities
纠正阿片类药物引起的突触异常的新机制
- 批准号:
10610455 - 财政年份:2021
- 资助金额:
$ 34.07万 - 项目类别:
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
研究阿片类药物诱导的突触可塑性和行为的新调控途径
- 批准号:
10516021 - 财政年份:2019
- 资助金额:
$ 34.07万 - 项目类别:
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
研究阿片类药物诱导的突触可塑性和行为的新调控途径
- 批准号:
10292973 - 财政年份:2019
- 资助金额:
$ 34.07万 - 项目类别:
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior
研究阿片类药物诱导的突触可塑性和行为的新调控途径
- 批准号:
10066256 - 财政年份:2019
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
7929354 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
8597367 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
ASICs in the n. accumbens in depression-related synaptic plasticity and behavior
n 中的 ASIC。
- 批准号:
8967085 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
8196333 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Brain pH and Acid Sensing in Depression-Related Behavior
抑郁相关行为中的大脑 pH 值和酸感应
- 批准号:
8391587 - 财政年份:2010
- 资助金额:
$ 34.07万 - 项目类别:
Modeling CO2-evoked fear in mice: role of acid-sensing ion channels
模拟二氧化碳引起的小鼠恐惧:酸敏感离子通道的作用
- 批准号:
8231507 - 财政年份:2009
- 资助金额:
$ 34.07万 - 项目类别: