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Role of Sulfiredoxin in Colorectal Cancer Development

硫氧还蛋白在结直肠癌发展中的作用

基本信息

批准号：
10314056
负责人：
Qiou Wei
金额：
$ 34.29万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10314056
关键词：
American Cancer Society Azoxymethane Back Binding Biological Biology C-terminal Cancer Etiology Cell Culture Techniques Cells Cessation of life Cetuximab Clinic Colorectal Cancer Data Deacetylation Development Diagnosis Distant Drug Kinetics Enzymes Epithelial Fc Receptor Free Radicals Future Goals Growth Growth Factor Receptors Human Individual International Knockout Mice Malignant Neoplasms Maximum Tolerated Dose Mediating Mesenchymal Mitogen-Activated Protein Kinases Molecular Mus Neoplasm Metastasis Oncogenic Organ Oxidation-Reduction Oxidative Stress Oxidoreductase Pathologist Patients Peroxidases Physicians Play Post-Translational Protein Processing Primary Neoplasm Process Receptor Activation Reporting Research Research Personnel Resistance Resources Role Route Scientist Signal Pathway Signal Transduction Site Sodium Dextran Sulfate Specimen Subcutaneous Injections Testing Therapeutic Toxic effect Tyrosine Phosphorylation Woman base cancer cell cancer diagnosis colon cancer patients colon carcinogenesis colon tumorigenesis colorectal cancer metastasis colorectal cancer treatment dextran sulfate sodium induced colitis dosage efficacy study efficacy testing enzyme activity fascin implantation insight men metastatic colorectal metastatic process mortality mouse model multidisciplinary novel novel therapeutics panitumumab patient derived xenograft model peroxiredoxin receptor small molecule inhibitor targeted cancer therapy translational applications tumorigenesis

项目摘要

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in USA and worldwide. One of the major causes of colorectal cancer mortality is due to the spreading of cancer cells from primary tumor sites to distant organs, a process known as cancer cell invasion and metastasis. This process is coordinately regulated by various biological molecules and their associated signaling pathways. The long-term objective of my research is to understand colon tumorigenesis and metastatic process by identifying critical molecular drivers, and to understand their function mechanisms to develope effective ways for targeted cancer therapy. Sulfiredoxin is a novel redox enzyme that has a critical role of promoting tumorigenesis and metastasis of colorectal cancer. In this project, our goals are to understand molecular mechanisms by which Sulfiredoxin promotes cancer cell invasion and metastasis, and to test the efficacy of a novel small molecule inhibitor of Srx in blocking human colorectal cancer invasion and metastasis using cell culture as well as mouse models.

结直肠癌是第三大最常见的诊断癌症和第二大癌症死亡原因在美国和全世界的男性和女性中。结直肠癌死亡的主要原因之一是由于癌细胞从原发肿瘤部位扩散到远处器官，这一过程称为癌细胞扩散。侵袭和转移。这一过程是由各种生物分子及其相关的信号通路。我研究的长期目标是了解结肠肿瘤的发生和转移过程，并了解其功能机制，发展有效的癌症靶向治疗方法。Sulfiredoxin是一种新的氧化还原酶，促进大肠癌的发生和转移。在这个项目中，我们的目标是了解硫氧还蛋白促进癌细胞侵袭和转移的分子机制，测试Srx的新型小分子抑制剂在阻断人结肠直肠癌侵袭中的功效，转移使用细胞培养以及小鼠模型。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Understanding the Role of the Peroxiredoxin Family in the Regulation of Ferroptosis in Colorectal Cancer.

了解过氧化还原蛋白家族在调节结直肠癌铁死亡中的作用。

DOI：
发表时间：
2022
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
0
作者：
Alshahrani,Aziza;Jiang,Hong;Thapa,Pratik;Ding,Na;Hao,Yanning;Wei,Qiou
通讯作者：
Wei,Qiou

Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and Cancer.

蛋白质二硫键异构酶是糖尿病和癌症之间缺失的一环。