Dopaminergic neuromodulation of social decision making

项目摘要/项目摘要 在社会上驾驭世界的能力与人类的健康和福祉密切相关， 跨越广泛的人类心理障碍，并取决于亲社会的选择在附属 竞争环境中的环境和战略学习。这类社会决策需要权衡 在最大化自己对他人的回报和学习他人的奖励偏好之间进行权衡。 神经成像研究表明，在人际经济游戏中，人类的决策会招募神经 与社会认知和报酬评估相关的结构。虽然之前的研究表明 多巴胺功能在涉及自我奖励的决策中是至关重要的，它在社会决策中的作用很大 不太为人所知。由于对社会决策的干扰涉及多种心理变态，与 多巴胺功能障碍(如ADHD和精神分裂症)，了解其机制是至关重要的 多巴胺会影响有关奖励的社会决策。为了解决这一问题，该提案的F99阶段将 研究人类的多巴胺功能与社会决策的关系。具体来说， 这项工作将结合正电子发射断层扫描(PET)、药理学、计算模型和 解决多巴胺个体差异与个人奖励关系的行为实验 处理和决策以及亲社会和战略性社会决策。这些研究的结果 将提供有关多巴胺能调节多种形式的社会决策的作用的关键信息 并可能最终阐明对亲社会行为和社会学习的干扰 精神变态。F99阶段的完成建立了强大的智力、技术和专业 该奖项的博士后(K00)阶段基金会。在K00阶段，培训将包括：学习 研究动态社会互动的新方法，了解多巴胺和其他神经调节剂如何 支持社会决策，并测试从属决策或竞争决策的差异是否有助于 观察到了精神病理学上的差异。这些目标将支持发展知识、专门知识、 以及成为一名独立调查员所必需的技能。

Project Summary/Project Abstract The ability to socially navigate the world has been strongly linked to health and well-being in humans and across a wide range of human psychological disorders and depends on prosocial choices in affiliative environments and strategic learning in competitive ones. These kinds of social decisions involve balancing tradeoffs between maximizing rewards for oneself versus others and learning from others’ reward preferences. Neuroimaging studies have shown that human decisions in interpersonal economic games recruit neural structures associated with social cognition and reward valuation. While previous studies have shown that dopamine function is paramount to decisions involving rewards for oneself, it’s role in social decisions is much less well understood. Since disruptions to social decision making span multiple psychopathologies linked to dopamine dysfunction (like ADHD and schizophrenia), it is critical to understand the mechanism by which dopamine influences social decisions about rewards. To address this, the F99 phase of this proposal will investigate the relationship between dopamine function and social decision making in humans. Specifically, this work will combine positron emission tomography (PET), pharmacology, computational modeling, and behavioral experiments to address how individual differences in dopamine relates to personal reward processing and decision making as well as prosocial and strategic social decisions. Results from these studies will provide critical information about the role of dopaminergic modulation of multiple forms of social decisions and may eventually shed light on disruptions to prosocial behavior and social learning across psychopathologies. Completion of the F99 phase sets a strong intellectual, technical, and professional foundation for the postdoctoral (K00) phase of this award. During the K00 phase, training will include: learning new methods to study dynamic social interactions, understanding how dopamine and other neuromodulators support social decisions, and testing whether differences in affiliative or competitive decisions contribute to observed differences in psychopathology. These goals will support the development of knowledge, expertise, and skills essential to becoming an independent investigator.