Marmoset Bioscience Meeting

摘要 本申请是为支持将于11月11日在伊利诺伊州芝加哥举行的第三届Marmoset生物科学研讨会(MBS)而提出的资金申请，这是2021年神经科学学会(SFN)会议开始的两天前。本次会议将注册为SFN卫星研讨会。常见的绒猴(Callithrix Jacchus)在全美的研究中经历了前所未有的增长，并在科学发现的下一章中迅速崛起，可能成为Keystone生物医学模型系统。这次会议的主要目标是多管齐下建立一个总部设在美国的财团的一部分，旨在突出绒猴的尖端研究，并将绒猴作为关键的模式系统进行推广。这次会议将为来自不同背景的资深研究人员和初级科学家提供一个网络论坛，以交流和交流他们的研究成果。绒猴模型成功的关键是培养该领域初级科学家的发展。这次会议还旨在吸引目前没有在研究中使用绒猴的研究人员。MBS的主要目标包括：(1)交流和传播在不同领域使用绒猴作为模式生物的新发现，并开发新的遗传、病毒和分析工具，以促进对绒猴的研究；(2)为讨论新的假设和方法以及文献中的差异提供一个开放的论坛，并促进抗体、方案和病毒工具箱等试剂的交流；(3)增加基础科学家与对在绒猴中模拟人类疾病感兴趣的翻译和临床小组之间的互动和合作，以及(4)提供一种氛围，使希望在研究中使用绒猴的研究人员可以直接与现有的研究人员互动。这些MBS与多个NIH IC的规划使命高度相关。会议包括主旨演讲、青年调查员讲座、从提交的摘要中挑选的受训者和青年调查员的特邀演讲，以及海报会议。这些会议提供了独特的特点组合，包括(1)研究的广度，(2)前沿问题和技术，(3)来自各级和不同分领域和地点的调查人员的混合，以及(4)亲密的规模和延长的讨论时间，以便进行持续的互动。计划了三个试探性的主题：(1)社会行为、生理和神经回路，(2)衰老和神经退行性疾病，以及(3)为绒猴研究开发的遗传、病毒和分析工具。最后，将强调妇女和任职人数不足群体的参与。一半的口头陈述将来自这些团体，一半的旅行奖项将颁发给女性。MBS本身的领导层约43%是女性。

Abstract This application is a request for funds to support the 3rd annual Marmoset Bioscience Symposium (MBS) to be held November 11, two days before the start of the 2021 Society for Neuroscience (SFN) meeting in Chicago, IL. This meeting will be registered as an SFN satellite symposium. The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of scientific discovery. The major goal of the meeting is part of a multiple-pronged approach to establish a U.S.-based consortium aimed at highlighting cutting-edge research in marmosets and promoting marmosets as a key model system. This meeting will provide a networking forum for both established investigators and junior scientists from diverse backgrounds to interact and communicate their research findings. Critical to the success of the marmoset model is fostering the development of junior scientists in the field. This meeting is also aimed at attracting investigators who are currently not using marmosets in their research. The principal objectives of the MBS include: (1) to communicate and disseminate new findings from using marmosets as a model organism in diverse fields and development of new genetic, viral, and analytic tools that will advance research in marmosets; (2) to provide an open forum for discussion of new hypotheses and approaches and discrepancies in the literature and to facilitate the exchange of reagents such as antibodies, protocols, and viral toolbox; (3) to increase interactions and collaborations between basic scientists and translational and clinical groups interested in modeling human disease in the marmoset and (4) to provide an atmosphere in which researchers wishing to use marmosets in their research may interact directly with established investigators. These MBSs are highly relevant to the programmatic mission of multiple NIH ICs. The meetings consist of a Keynote Lecture, Young Investigator talks, invited talks from trainees and young investigators that are selected from submitted abstracts, and poster sessions. These meetings offer a unique combination of features, including (1) breadth of research, (2) cutting-edge questions and technologies, (3) mingling of investigators from all ranks and diverse sub-fields and locales, and (4) intimate size and extended discussion time, allowing for sustained interactions. Three tentative themes are planned: (1) Social behavior, physiology, and neural circuits, (2) Aging and neurodegenerative disease, and (3) Genetic, viral, and analytic tools developed for marmoset research. Finally, participation by women and those from underrepresented groups will be emphasized. Half of the oral presentations will be from these groups and half of the travel awards will be given to women. The leadership of the MBS itself is ~43% female.