A scalable, synthetic retina: signal processing in droplet systems with DNA

可扩展的合成视网膜：DNA 液滴系统中的信号处理

• 批准号: DP210101892
• 负责人: A/Prof Matthew Baker
• 金额: $ 34.39万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101892
• 关键词: scalable; synthetic; retina; signal; processing

This project aims to design DNA-based nanotechnology for processing optical signals in synthetic biological systems. The intended outcome of this project is to develop a system for signal transduction in artificial bilayers using new DNA nanostructures. The anticipated goal of the project is to deliver: 1) light-based control of membrane protein insertion into artificial bilayers; 2) novel DNA-based pores that can transduce signals across membranes; 3) signal processing using multi-compartment biological components composed. Together, this technology allows us to use light and external signals to control biochemical pathways in synthetic systems.

该项目旨在设计基于DNA的纳米技术，用于处理合成生物系统中的光信号。该项目的预期成果是开发一种使用新的DNA纳米结构在人工双层中进行信号转导的系统。该项目的预期目标是提供：1）基于光的控制膜蛋白插入人工双层; 2）新型的基于DNA的孔，可以跨越膜传递信号; 3）使用多室生物成分组成的信号处理。总之，这项技术使我们能够使用光和外部信号来控制合成系统中的生化途径。