BIOINDUSTRY 4.0: RI services to promote deep digitalization of Industrial Biotechnology - towards smart biomanufacturing

工业生物技术(IB)是实现循环生物经济、产业更新和欧洲制造业自主的关键使能技术。它的发展是欧盟2050年实现气候中立战略的重要组成部分。要使IB成为一项主要的制造技术，它必须扩大对先进数字技术的使用。这些将提高研发效率，缩短上市时间和成本。此外，对于制造业来说，先进的数字技术将推动分布式、自治和高度适应性的生产系统。为了支持IB的数字化，BioIndustry 4.0将创建由欧洲研究基础设施(RI)提供的新服务。这些服务将解决几个挑战，重点是加快生物工艺开发管道的速度。利用其财团的互补技能，BioIndustry 4.0将开发数据驱动的方法，利用人工智能来支持新的决策支持系统和数字双胞胎，后者是为了更好地设计生物过程并实现他们的实时在线控制。为了完成这些服务，BioIndustry 4.0还将开发数据和元数据标准，以生成高质量、可互操作的多尺度生物过程数据，为可信数据网络和过程分析设备提供生物过程实时在线监测的技术基础。一旦部署，这些RI服务将为用户提供访问尖端技术的机会，这些技术可以单独使用或以集成的方式使用，覆盖整个研发管道。综合服务将由分布的国际扶轮提供，为欧洲提供独特的生物工艺开发研发试验台，并在全球竞争中具有竞争优势。为了取得成功，BioIndustry 4.0汇集了6个欧盟RIS、1个全球公司、2个创新的欧盟中小企业和几个研究团队，围绕着一个雄心勃勃的4年工作计划，该计划将与IB的利益相关者协商实施，使用共同设计战略来明确目标。

Industrial Biotechnology (IB) is a Key Enabling Technology for the circular bio-economy, industrial renewal and European manufacturing autonomy. Its development forms a vital part of EU’sstrategy to become climate neutral in 2050. For IB to become a major manufacturing technology, it must widen its use of advanced digital technologies. These will improve R&D efficiency, reducing time-to-market and costs. Moreover, for manufacturing, advanced digital technologies will drive distributed, autonomous and highly adaptable production systems. To support digitalization of IB, BIOINDUSTRY 4.0 will create new services delivered by European research infrastructures (RI). These services will address several challenges, focusing on the acceleration of bio-process development pipelines. Drawing on the complementary skills of its consortium, BIOINDUSTRY 4.0 will develop data-driven approaches, exploiting AI to empower novel decision support systems and digital twins, the latter being to better design bio-processes and enable their real-time online control. To complete these services, BIOINDUSTRY 4.0 will also develop data and metadata standards to generate high quality, interoperable multi scale bio-process data, the technical basis for trusted data networks and process analytical devices to provide real-time online monitoring of bio-processes. Once deployed, these RI services will provide Users with access to cutting-edge technologies that can be used singly or in an integrated way, covering whole R&D pipelines. Integrated services will be delivered by a distributed RI, conferring Europe with a unique R&D test-bed for bio-process development and a competitive advantage with respect to global competition. To succeed, BIOINDUSTRY 4.0 brings together 6 EU RIs, 1 global company, 2 innovative EU SMEs and several research teams around an ambitious 4-year workplan that will be implemented in consultation with IB stakeholders, using a co-design strategy to specify goals.