Pediatric Heart Network - Utah Center

儿科心脏网络 - 犹他中心

• 批准号: 10318614
• 负责人: L. LuAnn Minich
• 金额: $ 33.55万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318614
• 关键词: Address; Adult; Advocacy; Award; Bioinformatics; Cardiovascular system; Catchment Area; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Collaborations; Consent; Data; Databases; Development; Devices; Electrocardiogram; Enrollment; Ethics; Extramural Activities; Family; Fetus; Fostering; Funding; Genetic; Health; Heart; Heart Diseases; Individual; Industry; Infrastructure; Interdisciplinary Study; Investigation; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Leadership; Lesion; Manuscripts; Maternal-Fetal Medicine Units Network; Memory; Mentors; Mission; Modeling; Multicenter Neonatal Research Network; National Heart, Lung, and Blood Institute; Neonatal; Outcome; Patients; Performance; Pharmaceutical Preparations; Physicians; Pilot Projects; Population; Positioning Attribute; Process; Productivity; Protocols documentation; Public Health; Ramp; Recording of previous events; Registries; Research; Research Design; Research Infrastructure; Research Personnel; Residual state; Resource Development; Resources; Scholarship; Science; Scientist; Site; Source; Study Subject; Supervision; Teacher Professional Development; Time; Training; Translations; United States National Institutes of Health; Utah; Writing; base; clinical center; clinical investigation; congenital heart disorder; cost; data integration; experience; faculty mentor; flexibility; improved; improved outcome; innovation; multidisciplinary; next generation; novel; patient population; programs; protocol development; recruit; success; virtual

PROJECT SUMMARY/ABSTRACT As one of the most productive Core Centers in the NHLBI Pediatric Heart Network (PHN) since its inception in 2001, the Utah Center supported the PHN's mission to improve health outcomes in individuals with congenital heart disease (CHD) and children with acquired heart disease while training new investigators and providing support and advocacy for families during the conduct of high-impact, ethical clinical research. The research team has remained consistent throughout this time, making substantial contributions to PHN scientific discoveries and administrative activities. Long-standing collaboration among the Utah investigators and continued strong institutional support will allow uninterrupted leadership and seamless transition into the next award cycle. Recruitment and retention of study subjects has been among the highest of all Centers due to the commitment of the Utah team, around-the-clock coverage to approach every eligible patient, and access to large patient populations as the only Heart Center serving a wide catchment area. Site audits have commended the high quality, completeness, and timely entry of data from the Utah Center. Moving forward, the Utah Center is uniquely positioned for continued success under the new PHN flexible platform where studies may be funded by a variety of sources. Utah is currently one of only two Core Centers participating in all three consortia of the NHLBI Bench-to-Bassinet (B2B) program, and developed the Utah Integrative Science Committee to join B2B investigators with researchers from the NIH Neonatal Research and Maternal- Fetal Medicine Units Networks along with other expert clinical/translational cardiovascular researchers to foster team science. This committee guides a collaborative, multi-disciplinary research team that can strengthen bids for extramural funding. Utah participates in numerous multicenter databases and registries and will expedite the interface of these registries with PHN projects. Utah investigators currently lead PHN pilot studies obtaining preliminary data to propose larger clinical trials. The Utah Center has performed well in pharma-funded drug and device trials, and the Utah CCTS and Clinical Trials Office have a successful history of facilitating industry funded trials. Utah is committed to the next generation of physician-scientists and is ideally positioned to lead training initiatives with extensive faculty development resources and collaboration in numerous, relevant NIH Networks. The aims of the PHN Utah Center are: 1) continue exemplary performance and leadership, utilizing lessons learned in clinical trials administration to facilitate the PHN transition to a new flexible platform, 2) leverage state-of-the-art scientific capabilities through team science infrastructure to develop and expand the scientific resources and productivity of the PHN, and 3) provide training and mentoring for the next generation of physician-scientists to advance CHD research. The Utah Center's track record of successful leadership, state-of-the-art facilities, large catchment area, and extensive research and mentoring infrastructure will advance the PHN mission and allow new discoveries to improve outcomes in this population.

项目摘要/摘要 作为NHLBI儿科心脏网络(PHN)中最具生产力的核心中心之一，自 2001年，犹他州中心支持PHN改善先天性心脏病患者健康状况的使命 心脏病(CHD)和患有获得性心脏病的儿童，同时培训新的研究人员并提供 在进行高影响、合乎道德的临床研究期间，为家庭提供支持和倡导。这项研究 团队在这段时间里一直保持一致，为PHN科学做出了实质性贡献 发现和管理活动。犹他州调查人员和 持续的强有力的机构支持将允许不间断的领导和无缝过渡到下一个 颁奖周期。研究对象的招聘和保留一直是所有中心中最高的之一，因为 犹他州团队的承诺，全天候服务，接近每一位符合条件的患者，并获得 庞大的病人群体是唯一一个服务于广泛地区的心脏中心。现场审核有 赞扬犹他州中心数据的高质量、完整性和及时性。往前看， 犹他州中心在新的PHN灵活平台下具有独特的地位，可以继续取得成功 研究的资金来源可能多种多样。犹他州目前是仅有的两个核心中心之一 NHLBI长凳到摇篮(B2B)计划的所有三个财团，并开发了犹他州综合 科学委员会将与NIH新生儿研究和母体研究人员一起加入B2B调查人员 胎儿医学单位网络与其他专业临床/转化性心血管研究人员一起培养 团队科学。该委员会指导一个协作的、多学科的研究团队，可以加强投标 申请校外资金。犹他州参与了许多多中心数据库和注册，并将加快 这些登记处与公共卫生网络项目的接口。犹他州调查人员目前领导的PHN试点研究获得 提出更大规模临床试验的初步数据。犹他州中心在制药资助的药物方面表现良好 和设备试验，犹他州CCTS和临床试验办公室有促进行业发展的成功历史 资助的试验。犹他州致力于培养下一代内科科学家，并处于领先地位 培训计划，拥有广泛的教师发展资源，并与众多相关的NIH合作 网络。PHN犹他州中心的目标是：1)继续发挥模范绩效和领导力，利用 在临床试验管理方面吸取的经验教训，以促进PHN过渡到新的灵活平台，2) 通过团队科学基础设施利用最先进的科学能力来开发和扩展 PHN的科学资源和生产力；3)为下一代提供培训和指导 促进冠心病研究的内科科学家。犹他州中心成功领导的记录， 最先进的设施、大的集水区以及广泛的研究和指导基础设施将 推进PHN任务，并允许新发现改善这一人群的结果。